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    2-Bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and use thereof
    292.
    发明公开
    2-Bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and use thereof 失效
    的3-溴 - 和3,3-二溴-4-氧代 - 氮杂环丁烷2-溴 - 和2-硝基氧基衍生物，它们的制备方法以及它们的用途。

    公开(公告)号：EP0633247A1

    公开(公告)日：1995-01-11

    申请号：EP94110387.1

    申请日：1994-07-04

    Applicant: PLIVA FARMACEUTSKA KEMIJSKA PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO ZAGREB

    Inventor： Lukic, Irena

    IPC: C07D205/08 ,  C07D201/02 ,  A61K31/395

    CPC classification number: A61K31/395 ,  C07D205/08 ,  Y02P20/55

    Abstract: The invention relates to novel 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3-dibromo-4-oxo-azetidines, to processes for the preparation thereof and to the use thereof.
    According to the invention 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3-dibromo-4-oxo-azetidines are prepared by reacting derivatives of protected penicillanic acid 1,1-dioxides with DBN reactant (1,5-diazabicyclo/3.4.0/non-5-ene) and then the obtained DBN salt of sulfinic acid or isolated sulfinic acid is treated with thionyl chloride and, after eliminating thionyl chloride by evaporation, the obtained residue is passed through a silica gel column with methylene chloride or some other solvent as eluant or the obtained residue is dissolved in tetrahydrofuran or some other suitable solvent and treated with tetrabutyl ammonium bromide and after the treatment a derivative of 2-bromo, 3-bromo or 2-bromo-3,3-dibromo-4-oxo-azetidine is isolated, which derivative may be subjected to a reaction with silver nitrate in 2-propanol and, after the treatment of the reaction mixture, derivatives of 2-nitroxy-, 3-bromo- or 2-nitroxy-3,3-dibromo-4-oxo-azetidine are isolated.
    The obtained substances are useful intermediates in the syntheses of beta lactam analogons or as components in formulations having antibacterial, inhibitory, anti-tumour or antagonistic action.

    Abstract translation: 本发明涉及3-溴 - 和1,3-二溴-4-氧代 - 氮杂环丁烷的新的2-溴 - 和2-硝基氧基衍生物，流程，其制备方法和其用途。 。据的3-溴 - 和本发明2-溴 - 和2-硝基氧基衍生物的1,3-二溴-4-氧代 - 氮杂环丁烷是通过使受保护的青霉烷反应物的酸-1,1-二氧化物与DBN衍生物制备（1,5- 二氮杂双环/ 3.4.0 /壬-5-烯），然后亚磺酸或分离的亚磺酸的获得DBN盐治疗与亚硫酰氯，并通过蒸发消除亚硫酰氯后，将所得残余物通过用硅胶柱 二氯甲烷或一些其它溶剂作为洗脱剂或在得到的残渣的四氢呋喃或一些其它合适的溶剂中溶解，并用四丁基铵，溴化处理，并将处理后的2-溴，3-溴或2-溴-3,3-衍生物 二溴-4-氧代 - 氮杂环丁烷是隔离的，其中衍生物可经受在2-丙醇与硝酸银的反应，并且在反应混合物的处理后，2-硝基氧基，3-溴 - 或2-衍生物 硝酰基-3,3-二溴-4-氧代 - 氮杂环丁烷是分离的。 将所得到的物质是处于测试阶段内酰胺类似物的合成或作为具有抗菌，抑制，抗肿瘤或拮抗作用的式蒸发散部件是有用的中间体。

    Production of Lactams
    296.
    发明申请
    Production of Lactams 失效
    内华达州的生产

    公开(公告)号：US20090234115A1

    公开(公告)日：2009-09-17

    申请号：US11884883

    申请日：2006-02-14

    Applicant: Philippe Leconte

    Inventor： Philippe Leconte

    IPC: C07D201/02

    CPC classification number: C07D201/08 ,  Y02P20/52

    Abstract: Lactams, notably ε-caprolactam, are prepared from alkyl cyanovalerates, themselves obtained from unsaturated nitrile compounds, by contacting same, in gaseous state, with hydrogen in the presence of hydrogenation/cyclization catalysts, and then condensing the gas stream thus formed, without intermediate separation of any alkyl aminocaproate, and recovering lactam produced therefrom.

    Abstract translation: 内酰胺，特别是ε-己内酰胺，由本身由不饱和腈化合物获得的烷基氰基戊酸酯通过在氢化/环化催化剂存在下以气态与氢气接触而制备，然后将如此形成的气流冷凝而无中间体 分离任何烷基氨基己酸酯，并回收由其制备的内酰胺。

    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY
    297.
    发明申请
    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY 审中-公开
    制备具有改善颜色质量的N-ALKYL LACTAM的方法

    公开(公告)号：US20090182139A1

    公开(公告)日：2009-07-16

    申请号：US12296115

    申请日：2007-03-29

    Applicant: Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    Inventor： Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    IPC: C07D201/08 ,  C07D207/267 ,  C07D201/02 ,  C07D211/06

    CPC classification number: C07D201/18 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10

    Abstract: A process for preparing an N-alkyllactam with improved color quality, wherein from 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases from 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyllactam.A mixture comprising at least 99.0% by weight of an N-alkyllactam and in the range from 100 to 5000 ppm by weight of a C1-10-alcohol or of an acetal, aminal or of an orthoester which releases in the range from 100 to 5000 ppm by weight of a C1-10-alcohol.

    Abstract translation: 一种制备具有改进的颜色质量的N-烷基内酰胺的方法，其中将0.01至10重量％的C 1-10醇或从0.01至10重量％的C 1-10醇释放的化合物加入到 N-烷基内酰胺。 一种混合物，其包含至少99.0重量％的N-烷基内酰胺和100-5000重量ppm的C1-10醇或缩醛，缩醛或原酸酯，其释放范围为100至 5000重量ppm的C 1-10醇。

    Process for making caprolactam
    298.
    发明授权
    Process for making caprolactam 失效
    制备己内酰胺的方法

    公开(公告)号：US07060820B1

    公开(公告)日：2006-06-13

    申请号：US11083728

    申请日：2005-03-18

    Applicant: Sourav K. Sengupta ,  John J. Ostermaier ,  Gregory S. Kirby

    Inventor： Sourav K. Sengupta ,  John J. Ostermaier ,  Gregory S. Kirby

    IPC: C07D201/02

    CPC classification number: C07D201/08

    Abstract: Lactams, in particular ε-caprolactam, are produced by the hydrolytic cyclization of aminonitriles, in particular 6-aminocapronitrile, in the vapor phase in a plurality of adiabatic fixed bed reaction zones arranged in succession wherein at least a portion of the heat of the exothermic reaction is removed between each of the successive reaction zones. Conducting the reaction in such a manner requires less capital for the reactor itself. It has also been found that the product exiting such a reaction system can be directly fed to a distillation unit without the need of additional cooling or storing.

    Abstract translation: 内酰胺，特别是ε-己内酰胺，是通过氨基腈，特别是6-氨基己腈在气相中水解环化生成的，所述多个绝热固定床反应区依次布置，其中放热的至少一部分热量 在每个连续反应区之间除去反应。 以这种方式进行反应需要较少的反应堆本身资本。 还已经发现，离开这种反应体系的产物可以直接进料到蒸馏装置，而不需要额外的冷却或储存。

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