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    Stabilization of vinylether and vinyl lactam formulations against hydrolysis
    5.
    发明授权
    Stabilization of vinylether and vinyl lactam formulations against hydrolysis 有权
    乙烯基醚和乙烯基内酰胺配方的抗水解作用

    公开(公告)号：US06417356B1

    公开(公告)日：2002-07-09

    申请号：US09764641

    申请日：2001-01-18

    Applicant: Arvind M. Mathur ,  James A. Dougherty

    Inventor： Arvind M. Mathur ,  James A. Dougherty

    IPC: C07B6300

    CPC classification number: C07C41/46 ,  C07D201/18 ,  C07C43/16

    Abstract: This invention relates to a composition containing (a) a component selected from the group of a mono- or poly- vinyl substituted mono- or poly-ether, a mono- or poly- vinyl substituted lactam, or a mixture thereof contained in an acidic medium and (b) an aliphatic, primary or secondary mono- or poly-amine at a concentration sufficient to adjust the pH of the composition above

    Abstract translation: 本发明涉及一种组合物，其含有（a）选自单 - 或多 - 乙烯基取代的单醚或聚醚，单或多乙烯基取代的内酰胺或其包含在酸性中的混合物的组分 介质和（b）以足以调节上述组合物的pH的浓度的脂族，伯或仲或单 - 胺

    RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof
    8.
    发明申请
    RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof 审中-公开
    RS）-2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺化合物，其具有相似的作用的调节活性，药物（变体）及其用途，组合物（变体）

    公开(公告)号：US20140315972A1

    公开(公告)日：2014-10-23

    申请号：US14346445

    申请日：2012-09-20

    Applicant: Valentina Ivanovna Akhapkina ,  Roman Vitalyevich Akhapkin

    Inventor： Valentina Ivanovna Akhapkina ,  Roman Vitalyevich Akhapkin

    IPC: C07D207/27 ,  G01N31/16

    CPC classification number: G01N31/16 ,  A61K31/4015 ,  C07D201/16 ,  C07D201/18 ,  C07D207/27 ,  Y10T436/145555

    Abstract: The invention relates to a compound (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide having modulatory activity with a commensurate effect, to a pharmaceutical substance (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide containing: 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide—no less than 99.0% and no more than 100.5% on dry basis, individual related impurities individually or in total—no more than 0.2%; residual amounts of organic solvents individually or in total—no more than 3000 ppm. The invention also relates to a method for producing the pharmaceutical substance differing in that the obtained raw materials are subjected to purification, crystallization and stabilization of the compound by processing it with demineralized (distilled) water, and the isothermal crystallization from propanol followed by drying. The invention also relates to compositions for internal and external application. The invention provides higher efficacy, safety, stability and width of therapeutic application. 55 cl, 3 dwg, 80 tbl, 27 ex.

    Abstract translation: 本发明涉及具有相似作用的调节活性的化合物（RS）-2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺与药用物质（RS）-2-（2-氧代-4 - 2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺 - 不少于99.0％且不大于100.5％，单独或全部单独的相关杂质， 不超过0.2％; 剩余量的有机溶剂单独或总计不超过3000ppm。 本发明还涉及一种生产药物的方法，其不同之处在于，所得到的原料通过用软化（蒸馏）的水进行处理而进行化合物的纯化，结晶和稳定化，并用丙醇等温结晶，然后干燥。 本发明还涉及用于内部和外部应用的组合物。 本发明提供更高的疗效，安全性，稳定性和宽度的治疗应用。 55 cl，3 dwg，80 tbl，27 ex。

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