公开(公告)号：KR1020070109013A

公开(公告)日：2007-11-15

申请号：KR1020060041429

申请日：2006-05-09

Applicant: (주)아모레퍼시픽

Inventor： 박찬웅 ,  염명훈 ,  이진영 ,  주경미 ,  김연준 ,  이병곤

IPC: A61K8/97 ,  A61Q19/00

Abstract: A cosmetic composition comprising melanoidin is provided to improve wrinkles, promote collagen synthesis, recover skin damaged by the light contact, and show excellent skin anti-aging and moisturizing effects. A cosmetic composition comprises maillard reaction products generated during the red ginseng preparation, wherein the maillard reaction products in which saponin and oil-soluble ingredients are removed are separated through a dialysis membrane into a first fraction and an extra-solution of the dialysis, and the extra-solution is separated through gel-chromatography into a second fraction and a third fraction. The first fraction comprises melanoidin polymer having a molecular weight of less than 4,800, xylose, glucose, arginine, aspartic acid, glutamic acid, lysine, glycine and phenylalanine, the second fraction comprises maltulosyl arginine having a molecular weight of less than 4,000, serine, aspartic acid, glutamic acid, alanine, lysine and arginine, and a third fraction comprises fructosyl arginine having a molecular weight of less than 2,000, xylose, fructose, glucose, glycine, serine, glutamic acid and aspartic acid. The dried weight of the maillard reaction products regarding the total cosmetic composition is 10^-8-50 wt.%.

Abstract translation: 提供包含黑色素的化妆品组合物以改善皱纹，促进胶原蛋白合成，恢复由光接触损伤的皮肤，并且显示出优异的皮肤抗衰老和保湿作用。 化妆品组合物包含在红参制剂期间产生的美拉德反应产物，其中去除皂角苷和油溶性成分的美拉德反应产物通过透析膜分离成第一部分和透析的额外溶液， 通过凝胶色谱分离外溶液成为第二级分和第三份。 第一级分包含分子量小于4800的黑素基聚合物，木糖，葡萄糖，精氨酸，天冬氨酸，谷氨酸，赖氨酸，甘氨酸和苯丙氨酸，第二级分包含分子量小于4000的麦芽糖基精氨酸，丝氨酸， 天冬氨酸，谷氨酸，丙氨酸，赖氨酸和精氨酸，第三部分包含分子量小于2,000的果糖基精氨酸，木糖，果糖，葡萄糖，甘氨酸，丝氨酸，谷氨酸和天冬氨酸。 关于总化妆品组合物的美拉德反应产物的干燥重量为10 -8至50重量％。

公开(公告)号：KR100706279B1

公开(公告)日：2007-04-12

申请号：KR1020050108080

申请日：2005-11-11

Applicant: (주)아모레퍼시픽

Inventor： 이소현 ,  신의석 ,  조시영 ,  염명훈 ,  박찬웅 ,  이태룡 ,  이병곤 ,  장이섭

IPC: A61K31/352 ,  A61K31/366 ,  A61P3/04

Abstract: 본 발명은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A(Carnitine Palmitoyl Transferase1A) 유전자 발현을 촉진시킴으로써 지방산 베타 산화를 증가시키는 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물에 관한 것이다. 본 발명에 의한 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A의 발현을 세포 독성 없이 효과적으로 증가시킴으로써, 세포질 내 지방산이 미토콘드리아 내로 이동하는 것을 촉진하여 결과적으로 지방산의 베타 산화 증가에 도움이 된다. 따라서 본 발명에 의한 쿠메스트롤을 함유한 비만 개선용 조성물은 체지방의 과도한 축적을 예방 또는 개선하는데 도움이 된다.
쿠메스트롤, 제니스테인, 다이드제인, CPT1A, 지방산, 베타 산화

Abstract translation: 本发明ク手术刀包含拖网肉碱棕榈酰基转移酶1A氮杂促进（肉碱棕榈酰Transferase1A）基因表达通过涉及肥胖，改善和预防食品组合物的药物组合物和肥胖改善和预防用于增加脂肪酸β-氧化 。 肥胖改善和预防肥胖改善和预防食品组合物用于根据本发明通过将含区手术刀拖网肉碱棕榈酰转移酶的增加氮杂有效细胞1A表达而没有毒性的药物组合物，此举是脂肪细胞质内进入线粒体 因此有助于增加脂肪酸的β氧化。 因此，根据本发明的用于改善含有cumestrol的肥胖症的组合物有助于预防或改善体脂过度积聚。

公开(公告)号：KR1020040059270A

公开(公告)日：2004-07-05

申请号：KR1020020085863

申请日：2002-12-28

Applicant: (주)아모레퍼시픽

Inventor： 염명훈 ,  이종찬 ,  우광식 ,  강승현 ,  주경미 ,  김덕희 ,  장이섭

IPC: C08H7/00

Abstract: PURPOSE: A method for preparing secoisolariciresinol is provided to obtain a cosmetic composition having good absorptivity to the user's skin and excellent activity of inhibiting the formation of reactive oxygen species. CONSTITUTION: The method for preparing secoisolariciresinol comprises hydrolyzing flaxseed extract or secoisolariciresinol diglucoside separated therefrom. The hydrolysis is an acidic hydrolysis, alkaline hydrolysis or enzymatic hydrolysis. More particularly, the enzyme used in the enzymatic hydrolysis is selected from the group consisting of exo-glycolases and composite enzymes containing exo-glycolases. Further, the cosmetic composition contains the secoisolariciresinol in an amount of 0.0001 to 10 wt% based on the total weight of the composition.

Abstract translation: 目的：提供一种制备双异吲哚林醇的方法，以获得对使用者皮肤具有良好吸收性的化妆品组合物和抑制活性氧形成的优异活性。 构成：制备二异喹啉的方法包括水解亚麻籽提取物或与其分离的二异辛烯二醇二葡萄糖苷。 水解是酸性水解，碱性水解或酶水解。 更具体地，酶水解中使用的酶选自外消旋酶和含有外消旋酶的复合酶。 此外，化妆品组合物含有相对于组合物总重量为0.0001〜10重量％的二异辛烯硫酚。

公开(公告)号：KR1020030080429A

公开(公告)日：2003-10-17

申请号：KR1020020019032

申请日：2002-04-08

Applicant: (주)아모레퍼시픽

Inventor： 유병희 ,  강병영 ,  염명훈 ,  성대석 ,  주희경 ,  한상훈 ,  김한곤

IPC: A61K8/11 ,  A61Q5/02

Abstract: PURPOSE: A microemulsion particle containing 20-0-£α-L-arabinopyranosyl(1->6)-β-D-glucopyranosyl|-20(S)-protopanaxadiol separated from bioconversion of ginseng saponin is provided. The external preparation composition of skin using the same has an excellent effect of preventing skin aging, such as wrinkle improvement. CONSTITUTION: The microemulsion particle contains 10¬-8 to 99.9999% by weight of 20-0-£α-L-arabinopyranosyl(1->6)-β-D-glucopyranosyl|-20(S)-protopanaxadiol of the formula 1 as an effective ingredient and liposome containing lecithin, lecithin derivatives and a co-emulsifier, based on the total weight of the particle. In formula, R2 is OH and R3 is H. The microemulsion particle is prepared from acid hydrolysis, base hydrolysis or enzymolysis of ginseng extract and ginseng saponin. The cosmetic and pharmaceutical composition having excellent effects of proliferating skin cells and promoting collagen biosynthesis is obtained by formulation of the microemulsion particle.

Abstract translation: 目的：提供从人参皂角苷生物转化分离的含有20-0-α-L-阿拉伯吡喃糖基（1-> 6）-β-D-吡喃葡萄糖基| -20（S） - 原人参二醇的微乳液颗粒。 使用其的皮肤外用制剂组合物具有防止皮肤老化的良好效果，例如皱纹改善。 构成：微乳液颗粒含有10-80-99.9999重量％的式1的20-0-α-L-阿拉伯吡喃糖基（1-> 6）-β-D-吡喃葡萄糖基| -20（S） - 原人参二醇 作为含有卵磷脂，卵磷脂衍生物和辅助乳化剂的有效成分和脂质体，基于颗粒的总重量。 在式中，R2为OH，R3为H.微乳液颗粒由人参皂苷和人参皂苷的酸水解，碱水解或酶解制备。 通过配制微乳液颗粒获得具有增强皮肤细胞和促进胶原合成的优异效果的化妆品和药物组合物。