公开(公告)号：HK1203837A1

公开(公告)日：2015-11-06

申请号：HK15104584

申请日：2015-05-14

Applicant: STC UNM

Inventor： CHACKERIAN BRYCE ,  PEABODY DAVID ,  TUMBAN EBENEZER

IPC: A61K20060101 ,  A61P20060101 ,  C12N20060101

公开(公告)号：MX2015009222A

公开(公告)日：2015-10-15

申请号：MX2015009222

申请日：2014-01-16

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: B01J23/745 ,  B01J37/08 ,  H01M4/90

Abstract: Se describe un método basado en un soporte de protección, un método basado en mecanosíntesis, y un método combinado basado en un soporte superficial/soporte de mecanosíntesis que permite la producción de materiales catalíticos soportados o no soportados y/o la síntesis de materiales catalíticos de metal de transición tanto soluble como insoluble y de materiales de sal de transferencia de carga.

公开(公告)号：HK1201228A1

公开(公告)日：2015-08-28

申请号：HK15101794

申请日：2015-02-18

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B ,  MARTINEZ ULISES ANDRES

IPC: B01J20060101 ,  H01M20060101

公开(公告)号：CA2931784A1

公开(公告)日：2015-06-04

申请号：CA2931784

申请日：2014-11-26

Applicant: STC UNM

Inventor： BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

公开(公告)号：CA2922701A1

公开(公告)日：2015-03-05

申请号：CA2922701

申请日：2014-08-28

Applicant: STC UNM

Inventor： PLUSQUELLIC JAMES ,  AARESTAD JAMES

IPC: G06F11/30 ,  H05B44/00 ,  G06F11/16

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

公开(公告)号：SG11201401499XA

公开(公告)日：2014-09-26

申请号：SG11201401499X

申请日：2012-10-12

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  BRINKER C JEFFREY ,  CARNES ERIC C ,  FEKRAZAD MOHAMMAD HOUMAN ,  FELTON LINDA A ,  NEGRETE OSCAR ,  PADILLA DAVID PATRICK ,  WILKINSON BRIAN S ,  WILKINSON DAN C ,  WILLMAN CHERYL L

IPC: A61K31/7088 ,  A61K9/16 ,  A61K31/7105 ,  A61K38/17 ,  A61K47/48 ,  A61K48/00 ,  A61K49/08

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：CA2896623A1

公开(公告)日：2014-07-24

申请号：CA2896623

申请日：2014-01-16

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: B01J23/745 ,  B01J37/08 ,  H01M4/90

Abstract: A sacrificial support-based method, a mechanosynthesis-based method, and a combined sacrificial support/mechanosynthesis support based method that enables the production of supported or unsupported catalytic materials and/or the synthesis of catalytic materials from both soluble and insoluble transition metal and charge transfer salt materials.

公开(公告)号：AU2012352904A1

公开(公告)日：2014-07-24

申请号：AU2012352904

申请日：2012-10-31

Applicant: STC UNM

Inventor： DURVASULA RAVI ,  FORSHAW ADAM

IPC: A01N25/28 ,  A01N63/02 ,  A01P1/00

Abstract: Novel particular-based pesticides formed from pesticidal agents encapsulated in one or more coatings wherein the coating enhances the pesticidal agent' s ability to control a pest population, and methods for making the same. In various embodiments the pesticidal agent may be a biopesticide and the coating may impart stability, protection from UV radiation and/or other environmental conditions, enhance the attractiveness of the pesticide to the pest, and/or serve to separate two different biologically incompatible pesticides within a mixture.

公开(公告)号：CA2861021A1

公开(公告)日：2013-07-18

申请号：CA2861021

申请日：2013-01-10

Applicant: STC UNM

Inventor： CHACKERIAN BRYCE ,  PEABODY DAVID ,  TUMBAN EBENEZER

IPC: A61K39/12 ,  A61P31/20 ,  C12N7/01

Abstract: In one aspect, the invention provides immunogenic HPV L2-containing viral-like particles (VLPs). Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. In certain aspects, the VLPs are comprised of a coat polypeptide of the bacteriophages PP7 or MS2, wherein the coat protein is modified by insertion of peptide antigens derived from HPV L2, and wherein the HPV L2 peptide is displayed on the VLP and encapsidates PP7 or MS2 mRNA. Specifically, VLPs of the invention display L2 peptides at the N- terminus of the bacteriophage coat protein. Surprisingly, these L2-displaying VLPs induce more broadly neutralizing antibody responses than when the same peptide is displayed in the AB-loop such that the immunogenic response is enhanced by a factor of at least 10. Immunogenic VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo.

公开(公告)号：DE112011101133T8

公开(公告)日：2013-04-25

申请号：DE112011101133

申请日：2011-03-23

Applicant: DAIHATSU MOTOR CO LTD ,  STC UNM

Inventor： ASAZAWA KOICHIRO ,  YAMADA KOJI ,  TANAKA HIROHISA ,  YAMAMOTO KAZUYA ,  PYLYPENKO SVITLANA ,  ATANASSOV PLAMEN ,  OLSON TIM

IPC: H01M4/90 ,  H01M8/02 ,  H01M8/10