公开(公告)号：US20190192700A1

公开(公告)日：2019-06-27

申请号：US16181904

申请日：2018-11-06

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/08 ,  A61K45/06 ,  A61K31/7068 ,  A61K38/31

CPC classification number: A61K51/08 ,  A61K31/7068 ,  A61K38/31 ,  A61K45/06 ,  A61K51/083 ,  A61K51/088 ,  A61K2300/00

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

公开(公告)号：US20190160188A1

公开(公告)日：2019-05-30

申请号：US16265295

申请日：2019-02-01

Applicant: STC.UNM

Inventor： Yubin Miao

IPC: A61K51/08 ,  C07K7/56 ,  A61K38/17

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

公开(公告)号：US20190128894A1

公开(公告)日：2019-05-02

申请号：US15801070

申请日：2017-11-01

Applicant: STC.UNM

Inventor： Ravinder Jain ,  Abhaya K. Datye ,  Ying-Bing Jiang

IPC: G01N33/58 ,  A61K41/00 ,  A61K9/51 ,  A61P35/00 ,  G01N33/84 ,  G01N21/65

Abstract: A method of making free-standing ALD-coated plasmonic nanoparticles. The method comprises providing a plurality of semiconductor quantum dots. One or more conformal layers of dielectric material are deposited over the quantum dots to form dielectric-coated quantum dots. A conformal metallic nanoshell is deposted over the dielectric-coated quantum dots to form plasmonic nanoparticles. At least one layer chosen from i) the conformal layers of dielectric material and ii) the conformal metallic nanoshell is deposited using a vapor phase atomic layer deposition (ALD) process. Plasmonic nanoparticles and systems employing the nanoparticles are also disclosed.

公开(公告)号：US10266904B2

公开(公告)日：2019-04-23

申请号：US15027069

申请日：2014-09-24

Applicant: STC.UNM

Inventor： Jeremy Scott Edwards

IPC: C12Q1/68 ,  C12Q1/689 ,  C12Q1/6853

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

公开(公告)号：US10248764B2

公开(公告)日：2019-04-02

申请号：US15721277

申请日：2017-09-29

Applicant: STC.UNM

Inventor： Roy William Keyes ,  Christian Romano ,  Shuang Luan ,  Dorian C. Arnold

IPC: G06F19/00 ,  G16H50/50 ,  G06F9/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

公开(公告)号：US20190091150A1

公开(公告)日：2019-03-28

申请号：US16025557

申请日：2018-07-02

Applicant: STC.UNM ,  Sandia Corporation

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704 ,  A61K33/24 ,  A61K47/69 ,  C07K14/47 ,  A61K45/06 ,  A61K47/62 ,  C12N15/88 ,  A61K39/05 ,  C12N15/113 ,  A61K31/711 ,  A61K48/00 ,  A61K38/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：US20190089355A1

公开(公告)日：2019-03-21

申请号：US16185921

申请日：2018-11-09

Applicant: STC.UNM

Inventor： James Plusquellic ,  James Aarestad

IPC: H03K19/003 ,  H03K23/00 ,  H03K3/84 ,  H04L9/08 ,  H03K19/21 ,  H04L9/06

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

公开(公告)号：US20190051783A1

公开(公告)日：2019-02-14

申请号：US16160272

申请日：2018-10-15

Applicant: STC.UNM

Inventor： Majeed M. Hayat ,  Payman Zarkesh-Ha

IPC: H01L31/107 ,  H03F3/08 ,  H01L25/16

CPC classification number: H01L31/107 ,  H01L25/167 ,  H03F1/0261 ,  H03F1/083 ,  H03F3/08 ,  H03F3/087 ,  H03F3/45475 ,  H03F2203/45112

Abstract: Systems and methods implementing a resonance circuit, including an avalanche photodiode, in which a resonance frequency of the resonance circuit is matched with the frequency of a dynamic biasing signal of the avalanche photodiode, can be used in a variety of applications. In various embodiments, a method for blocking and/or compensating current injection associated with the parasitic capacitance of APDs operated under dynamic biasing may be substantially realized by the matching of the resonance frequency of a resonance circuit including the avalanche photodiode with the frequency of an applied dynamic biasing signal. Additional systems and methods are described that can be used in a variety of applications.

公开(公告)号：US20190000830A1

公开(公告)日：2019-01-03

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K31/473 ,  A61K31/4741 ,  A61K35/644 ,  A61K38/14 ,  A61K45/06 ,  A61P31/04 ,  C07K14/70567 ,  A61K2300/00

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition—and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US10164082B2

公开(公告)日：2018-12-25

申请号：US15466461

申请日：2017-03-22

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Seung-Chang Lee ,  Christian Wetzel ,  Mark Durniak

IPC: H01L29/778 ,  H01L21/02 ,  H01L21/306 ,  H01L29/66 ,  H01L29/205 ,  H01L29/08 ,  H01L21/78 ,  H01L29/04 ,  H01L29/423 ,  H01L29/06 ,  H01L33/00 ,  H01L33/32 ,  H01L29/40 ,  H01L33/24

Abstract: A transistor comprises a substrate comprising a Group III/V compound semiconductor material having a cubic crystalline phase structure positioned on a hexagonal crystalline phase layer having a first region and a second region, the cubic crystalline phase structure being positioned between the first region and the second region of the hexagonal crystalline phase layer. A source region and a drain region are both positioned in the Group III/V compound semiconductor material. A channel region is in the Group III/V compound semiconductor material. A gate is over the channel region. An optional backside contact can also be formed. A source contact and electrode are positioned to provide electrical contact to the source region. A drain contact and electrode are positioned to provide electrical contact to the drain region. Methods of forming transistors are also disclosed.