公开(公告)号：US10561648B2

公开(公告)日：2020-02-18

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61K35/644 ,  A61K38/14 ,  C07K14/705 ,  A61K31/4741 ,  A61P31/04

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition —and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US20190000830A1

公开(公告)日：2019-01-03

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K31/473 ,  A61K31/4741 ,  A61K35/644 ,  A61K38/14 ,  A61K45/06 ,  A61P31/04 ,  C07K14/70567 ,  A61K2300/00

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition—and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.