公开(公告)号：JPS58162556A

公开(公告)日：1983-09-27

申请号：JP4515282

申请日：1982-03-20

Applicant: TAISHO PHARMA CO LTD

Inventor： HATAYAMA KATSUO ,  NAKAZATO ATSUO ,  OGAWA TOSHIHISA ,  ITOU SHIYOUICHI ,  SAWADA JIROU

IPC: C07C201/02 ,  C07C67/00 ,  C07C201/00 ,  C07C203/04

Abstract: NEW MATERIAL:The compound of formula (R is 2-3C mononitratoalkyl or dinitratoalkyl). EXAMPLE:Acetoacetic acid 2-nitratoethyl ester. USE:Synthetic raw material of a dihydropyridine derivative useful as a remedy for coronary vessel circulation disorder, hypertension, etc. PROCESS:The compound of formula can be prepared by reacting a diketene with an alcohol of formula HO-R in the presence of a basic catalyst such as triethylamine, sodium acetate, etc.

公开(公告)号：JPS56167642A

公开(公告)日：1981-12-23

申请号：JP5931381

申请日：1981-04-21

Applicant: DU PONT

Inventor： ROBAATO MATSUKOORU

IPC: C07C201/16 ,  B01J14/00 ,  B01J19/14 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/08 ,  C07C205/06 ,  C07C205/10 ,  C07C205/11 ,  C07C205/12 ,  C07C209/36

公开(公告)号：WO2022167070A1

公开(公告)日：2022-08-11

申请号：PCT/EP2021/052553

申请日：2021-02-03

Applicant: NICOX S.A.

Inventor： ALMIRANTE, Nicoletta ,  RONSIN, Gael ,  DIKER, Khalid ,  GORINS, Gilles ,  COUSIN, Jonathan ,  BRUNEAU, Audrey

IPC: C07C405/00 ,  C07C201/02 ,  C07C203/02

Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6- {[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.

公开(公告)号：WO2020053194A1

公开(公告)日：2020-03-19

申请号：PCT/EP2019/074072

申请日：2019-09-10

Applicant: DSM IP ASSETS B.V.

Inventor： EGGEL, Michael ,  KAPFERER, Peter ,  LUETHI, Erika

IPC: C07C201/02 ,  C07C203/04 ,  A61K31/04 ,  A61K31/045 ,  A23K20/105 ,  A23K50/10

Abstract: The invention relates to a process for the preparation of ω-nitroxyC 3-1 0 alkane-1-ols comprising the nitration of an α,ω-C 3-10 alkanediol with a nitration agent, optionally in the presence of a nitrite trapping agent, characterized in that the nitration agent is a mixture consisting of 50 to 75 wt.-% of nitric acid in water wherein the nitric acid is used in an amount selected in the range from 0.5 to 5 mol equivalents based on the α,ω--C 3-10 alkanediols, and wherein the nitration is carried out at a temperature selected in the range from 65 - 100°C.

公开(公告)号：WO2015134703A1

公开(公告)日：2015-09-11

申请号：PCT/US2015/018876

申请日：2015-03-05

Applicant: CORNING INCORPORATED

Inventor： MA, Bing ,  SHEN, Wei ,  WANG, Yanhua ,  ZHANG, Mo

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol into said flow reactor so as to mix the isooctyl alcohol with the H2SO4-HNO3 mixture and produce a reaction mixture stream flowing in said reactor, maintaining the reaction mixture stream flowing in said flow reactor at a reaction temperature within in the range -10° to 35°C inclusive, and wherein the residence time of the reaction mixture stream in the flow reactor is greater than or equal to 5 seconds and less than or equal to 40 seconds, and wherein the H2SO4 of the H2SO4-HNO3 mixture is H2SO4 having a concentration of in the range of 85 to 95% inclusive, more desirably 88 to 92% inclusive, most desirably of 90%.

Abstract translation: 在连续流动反应器中合成硝酸异辛酯的方法包括使流动反应器内的H 2 SO 4 -HNO 3混合物流动，将异辛醇流入所述流动反应器中，以将异辛醇与H 2 SO 4 -HNO 3混合物混合并产生流动的反应混合物流 在所述反应器中，保持反应混合物流在所述流动反应器中流动的反应温度在-10℃至35℃的范围内，并且其中反应混合物流在流动反应器中的停留时间大于或等于 至5秒且小于或等于40秒，并且其中H 2 SO 4 -HNO 3混合物的H 2 SO 4为浓度为85-95％（含）的H 2 SO 4，更优选为88-92％，最优选为90 ％。

公开(公告)号：WO2005077883A8

公开(公告)日：2006-10-26

申请号：PCT/EP2005001505

申请日：2005-02-15

Applicant: DYNAMIT NOBEL AG ,  ANTES JUERGEN ,  BOSKOVIC DUSAN ,  HAASE JUERGEN ,  LOEBBECKE STEFAN ,  RULOFF CORNELIUS ,  TUERCKE TOBIAS

Inventor： ANTES JUERGEN ,  BOSKOVIC DUSAN ,  HAASE JUERGEN ,  LOEBBECKE STEFAN ,  RULOFF CORNELIUS ,  TUERCKE TOBIAS

IPC: C07C201/02 ,  B01J19/00

CPC classification number: C07C201/02 ,  B01J19/0093 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00889 ,  C07C203/06

Abstract: The invention relates to a method for the production of liquid nitrate esters, e.g. nitro-glycerine, wherein an alcohol is esterified by means of nitrating acid and the reaction takes place in one or several microreactors.

Abstract translation: 公开了一种用于生产液体硝酸酯，例如的方法 在其中的醇是由硝化酸，其中所述反应是在一种或多种微反应器硝酸甘油进行的手段酯化。

公开(公告)号：WO2004043898A1

公开(公告)日：2004-05-27

申请号：PCT/EP2003/012376

申请日：2003-11-06

Applicant: DINAMITE DIPHARMA S.P.A. (In Abbreviated form DIPHARMA S.P.A.) ,  FRANCESCUTTI, Nevio ,  SCUBLA, Tiziano ,  GORASSINI, Fausto ,  CASTALDI, Graziano

Inventor： FRANCESCUTTI, Nevio ,  SCUBLA, Tiziano ,  GORASSINI, Fausto ,  CASTALDI, Graziano

IPC: C07C201/02

CPC classification number: C01B21/46 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the preparation of compounds of formula: HO-A-ONO 2 (I) wherein A is a C 2 -C 6 alkylene chain by nitration of the corresponding alkanediols with "stabilised" nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

Abstract translation: 本文公开了通过用“稳定”的硝酸硝化相应的链烷二醇来制备其中A为C2-C6亚烷基链的式HO-A-ONO 2（I）的化合物的方法。 该过程对操作员更安全，并允许在工业规模上获得有利的产量。

公开(公告)号：US20200140372A1

公开(公告)日：2020-05-07

申请号：US16413322

申请日：2019-05-15

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chih-Lung CHIN ,  Shih-Hsien LIU ,  Wan-Chi CHEN ,  Kung-Lung CHENG

IPC: C07C201/02 ,  C07D493/04 ,  B01J19/00

Abstract: A method for preparing a nitrate ester is provided. The method includes providing a first solution including a compound (which has at least one hydroxyl group) and a carboxylic acid having 2-5 carbon atoms; providing a second solution including nitric acid, acetic anhydride, and acetic acid; and transferring the first solution and the second solution to a microreactor, obtaining a nitrate ester after a residence time. In particular, the ratio of the weight of nitric acid to the total volume of the acetic anhydride and acetic acid is 1:1 to 1:3.5. The ratio of the molar amount of nitric acid to the hydroxyl group equivalent of the compound is from 1:1 to 15:1.

公开(公告)号：US09273020B2

公开(公告)日：2016-03-01

申请号：US14394508

申请日：2013-04-11

Applicant: Haldor Topsøe A/S

Inventor： Niels Christian Schjødt ,  John Bøgild Hansen ,  Claus Friis Pedersen

IPC: C07D305/00 ,  C07C69/96 ,  C07C51/14 ,  C07D305/12 ,  C07C67/38 ,  C07C68/00 ,  C07C201/02 ,  C07D301/04 ,  C25B1/02 ,  C25B15/08 ,  C25B1/00 ,  C07C67/035 ,  C07C68/04

CPC classification number: C07D305/12 ,  C07C51/14 ,  C07C67/035 ,  C07C67/38 ,  C07C68/005 ,  C07C68/04 ,  C07C201/02 ,  C07D301/04 ,  C25B1/00 ,  C25B1/02 ,  C25B15/08 ,  Y02E60/366 ,  Y02P20/133 ,  Y02P20/134 ,  Y02P20/582 ,  C07C203/04 ,  C07C69/96 ,  C07C53/124 ,  C07C69/24

Abstract: Process for the production of a chemical compound from a carbon dioxide starting material, comprising the steps of a) providing a feed stream consisting mainly of carbon dioxide; b) electrolyzing in an electrolysis stage the carbon dioxide in the feed stream to a first gas stream containing carbon monoxide and a second gas stream containing oxygen, wherein the molar ratio between carbon monoxide and oxygen is about 1:0.5 in an electrolysis stage; c) adjusting the composition of the first gas stream or the second gas stream or both gas streams to include carbon dioxide, either by operating at less than full conversion of CO2 or by sweeping one or both gas streams with a gas containing CO2 or by at some stage between the electrolysis cell and the oxidative carbonylation reactor diluting one or both gas streams with a gas containing CO2; all while maintaining an overall molar ratio of carbon monoxide to oxygen of about 1:0.5; and d) introducing the first and second process stream into a reaction stage and reacting the first and second process stream combined or in succession with a substrate to the chemical compound by means of an oxidative carbonylation reaction with the carbon monoxide and oxygen contained in the process feed stream.

Abstract translation: 用于从二氧化碳原料生产化合物的方法，包括以下步骤：a）提供主要由二氧化碳组成的进料流; b）在电解阶段中将进料流中的二氧化碳电解成含有一氧化碳和含有氧的第二气流的第一气流，其中在电解阶段一氧化碳和氧之间的摩尔比为约1:0.5; c）调节第一气流或第二气流或两种气流的组成以包括二氧化碳，或者通过以少于二氧化碳的全部转化率进行操作，或者通过用含有CO 2的气体或通过在 在电解池和氧化羰基化反应器之间的某个阶段，用含CO 2的气体稀释一种或两种气流; 同时保持一氧化碳与氧的总摩尔比为约1:0.5; 和d）将第一和第二工艺流引入反应阶段，并通过与该方法中所含的一氧化碳和氧气进行氧化羰基化反应，将第一和第二工艺流与底物组合或连续地与化学化合物反应 饲料流。

公开(公告)号：US08536366B2

公开(公告)日：2013-09-17

申请号：US12808829

申请日：2008-12-19

Applicant: Sascha Braune ,  Stefan Steinhofer ,  Peter Poechlauer ,  Rafael Wilhelmus E. G. Reintjens ,  Nicole Theodora W. Linssen ,  Mehul Thathagar

Inventor： Sascha Braune ,  Stefan Steinhofer ,  Peter Poechlauer ,  Rafael Wilhelmus E. G. Reintjens ,  Nicole Theodora W. Linssen ,  Mehul Thathagar

IPC: C07C201/02 ,  C07C201/16 ,  B01J14/00 ,  B01D11/04

CPC classification number: B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00966 ,  B01J2219/00984 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

Abstract translation: 在二相溶剂系统中连续制备其中R 1为具有3至6个碳原子的直链烷基的式（II）化合物HO-R1-ONO2（Ⅱ）的方法，包括使 式（I）化合物，其中R 1如上定义的HO-R 1 -OH（I）与硝酸在第一溶剂存在下反应，其中将式（II）化合物连续萃取到第二溶剂中， 反应在混合微反应器中进行，该混合微反应器通过圆形截面直通微反应器提供至少1.3相同条件下功率损耗的功率损失，该反应器的内径等于混合微反应器的平均水力直径 长度等于混合微反应器的长度。