公开(公告)号：WO1995004061A1

公开(公告)日：1995-02-09

申请号：PCT/US1994008646

申请日：1994-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  LULY, Jay, R.

IPC: C07D498/18

CPC classification number: C07D498/18 ,  C07F7/1804

Abstract: Activated macrolactam compounds having immunomodulatory activity and having formula (I), wherein n is zero or one, R is selected from the group consisting of methyl, ethyl, allyl, propyl and cyclopropylmethyl; R is hydrogen, and R is selected from the group consisting of hydrogen, hydroxy and a protected hydroxy group or, taken together, R and R form a bond; R and R are chosen such that one is hydrogen while the other is -OS(O)2F; and R is selected from the group consisting of hydrogen, a protected hydroxy group, lower alkyl, alkenyl, cycloalkyl, aryl and arylalkyl, as well as processes for making such compounds and methods for their use in the preparation of C-32-modified derivatives of ascomycin or the congeners or analogs thereof.

Abstract translation: 具有免疫调节活性并具有式（I）的活性大分子内酰胺化合物，其中n为0或1，R 101选自甲基，乙基，烯丙基，丙基和环丙基甲基; R 102是氢，R 103选自氢，羟基和被保护的羟基，或者R 102和R 103一起形成一个键; R 104和R 105选自一个为氢，另一个为-OS（O）2 F; R 106选自氢，被保护的羟基，低级烷基，烯基，环烷基，芳基和芳基烷基，以及制备这些化合物的方法及其用于制备C-32的方法 修饰的子囊霉素衍生物或其同系物或类似物。

公开(公告)号：WO1995001794A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007575

申请日：1994-07-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  EDWARDS, Carla ,  LARTEY, Paul, A.

IPC: A61K31/70

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II) and pharmaceutically acceptable salts thereof, wherein Y is selected form (a), (b), and (c) and X is selected from the group consisting of -C(O)-, -C(S)-, CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

Abstract translation: 具有式（II）的抗菌化合物及其药学上可接受的盐，其中Y选自（a），（b）和（c）形式，X选自-C（O） - ， - C ） - ，CH 2 - ， - CH 2 CH 2 - 和-C（CH 3）2 - ; 还公开了可用于制备上述化合物的方法和中间体，以及含有该化合物的组合物及其使用方法。

公开(公告)号：WO1994029456A2

公开(公告)日：1994-12-22

申请号：PCT/US1994005920

申请日：1994-05-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  STEFFY, Kevin, R. ,  KATI, Warren, M. ,  KATZ, Leonard ,  McGONIGAL, Thomas, P. ,  SARTHY, Aparna, V. ,  SCHOEN, Sharon, E.

IPC: C12N15/57

CPC classification number: C07K16/087 ,  C12N9/503

Abstract: Protease activity associated with herpes simplex virus (HSV) type 2 was identified. The complete nucleotide and amino acid sequence of the protease was determined. The HSV-2 nucleic acid segment encoding the protease substrate ICP35 was also sequenced. Recombinant vectors and host cells for expressing the protease are also described.

Abstract translation: 鉴定了与单纯疱疹病毒（HSV）2型相关的蛋白酶活性。 确定蛋白酶的完整核苷酸和氨基酸序列。 编码蛋白酶底物ICP35的HSV-2核酸片段也被测序。 还描述了用于表达蛋白酶的重组载体和宿主细胞。

公开(公告)号：WO1994027655A1

公开(公告)日：1994-12-08

申请号：PCT/US1994004214

申请日：1994-04-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GOLDHARDT, Donald, Jay ,  HIRSCH, William, Henry

IPC: A61M01/00

CPC classification number: A61J15/0092 ,  A61J15/0015 ,  A61J15/0038 ,  A61J15/0065 ,  A61M2025/0233

Abstract: A gastrostomy device (30) for easier insertion into an established stoma is provided with an apertured dome (34) connected at its bottom wall to a tubular shaft (31), wherein the dome is particularly characterized by having the sidewall (38) thinned from apex to bottom wall whereby the dome, when elongated with an obturator, stretches smoothly and readily to very close to the diameter of the tubular shaft. The device is ordinarily provided with a one-way valve (42) mounted in the dome as well as with a retention flange (32) at the outer end of the tubular shaft. Preferably the one-way valve is a cross-slit duckbill valve of novel design.

Abstract translation: 用于更容易地插入建立的造口的胃造口术装置（30）设置有在其底壁处连接到管状轴（31）的有孔圆顶（34），其中，圆顶的特征在于使侧壁（38）从 顶端到底壁，由此，当用闭孔器细长时，圆顶平滑且容易地伸展到非常接近管状轴的直径。 该装置通常设置有安装在圆顶中的单向阀（42）以及在管状轴的外端具有保持凸缘（32）。 优选地，单向阀是新颖设计的十字切口鸭嘴阀。

公开(公告)号：WO1994025055A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004755

申请日：1994-04-29

Applicant: ABBOTT LABORATORIES ,  OKASINSKI, Gregory, F. ,  DeVRIES, Peter, J. ,  MELLOVITZ, Barry, S. ,  MEUTH, Joseph, L. ,  SCHAEFER, Verlyn, G.

Inventor： ABBOTT LABORATORIES

IPC: A61K37/02

CPC classification number: C12N15/85 ,  A61K38/00 ,  C07K14/505

Abstract: Analogs of human erythropoietin, including the [X ,Cys ,des-Arg ] and [Cys ,des-Arg ] analogs, as well as methods for making and using such analogs and pharmaceutical compositions containing the same.

Abstract translation: 人类促红细胞生成素的类似物，包括[X 33，Cys 139，des-Arg 166]和[Cys 139，des-Arg 166]类似物，以及制备和使用 类似物和含有它们的药物组合物。

公开(公告)号：WO1994023775A1

公开(公告)日：1994-10-27

申请号：PCT/US1994003077

申请日：1994-03-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LARKIN, Mark, E. ,  KRAMER, David, E. ,  FREDERICK, Warren, P.

IPC: A61M05/32

CPC classification number: A61M39/045 ,  A61M39/1011 ,  A61M2039/1027 ,  A61M2039/1072 ,  Y10S604/905

Abstract: A securing collar (10) is used in combination with two tubular flow connectors (12, 14) to prevent the inadvertent disconnection of I.V. tubing sets. The securing collar (10) includes a housing (26) supported by one of the connectors, a radial flange (42) extending from the housing (26), a tubular collar (44) having an outwardly splayed end, at least two notches (52) that separate the splayed collar (44) into at least two elongated segments, a transition portion (54) on the exterior of the collar, and a sliding annular locking ring (60). The locking ring (60) slides on the collar (44) from the proximal end over the transition portion to the distal segments so that the annular locking ring (60) forces the splayed and segmented distal portions radially inward to grip the second connector.

Abstract translation: 固定环（10）与两个管状流动连接器（12,14）组合使用，以防止IV的意外断开。 管套。 所述固定环（10）包括由所述连接器之一支撑的壳体（26），从所述壳体（26）延伸的径向凸缘（42），具有向外张开的端部的管状套环（44），至少两个凹口 将所述凸出的轴环（44）分成至少两个细长段，所述轴环的外部上的过渡部分（54）和滑动环形锁定环（60）。 锁定环（60）在过渡部分上的近端处在轴环（44）上滑动到远侧段，使得环形锁定环（60）径向向内迫使张开的和分段的远端部分夹持第二连接器。

公开(公告)号：WO1994022858A1

公开(公告)日：1994-10-13

申请号：PCT/US1994002894

申请日：1994-03-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MICHAELIDES, Michael, R. ,  HONG, Yufeng

IPC: C07D471/00

CPC classification number: C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: A tetracyclic compound of formula (I) wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from formulas (a), (b), (c), (d) and (e) wherein R , R , R , R and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.

Abstract translation: 式（I）的四环化合物，其中A及其所连接的原子和任选的双键表示选自式（a），（b），（c），（d）的单 - 或二 - 杂环， 和（e）其中R 1，R 2，R 3，R 4和X是具体定义的，哪些化合物可用于治疗多巴胺相关的神经，心理和心血管疾病以及 在治疗药物滥用和其他成瘾行为障碍，认知障碍和注意力缺陷障碍。

公开(公告)号：WO1994022381A1

公开(公告)日：1994-10-13

申请号：PCT/US1994002728

申请日：1994-03-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MANOSALVA, Edgar, Gilberto ,  ROSS, Jeffrey, R. ,  GOLDHARDT, Donald, Jay

IPC: A61B17/06

CPC classification number: A61B17/0469 ,  A61B17/0401 ,  A61B17/06061 ,  A61B17/06133 ,  A61B17/8695 ,  A61B50/22 ,  A61B2017/0406 ,  A61B2017/0409 ,  A61B2017/0416 ,  A61B2017/0417 ,  A61B2017/0479 ,  A61B2017/06142 ,  A61B2050/314

Abstract: A T-fastener installation kit (10) includes a packaging device (13) for loading a T-fastener (19) into a slotted needle (18) without requiring the hands of the surgeon to touch the sharp end of the needle. T-fasteners may be commonly used, for example, in surgical procedures in which the T-fasteners are used to secure a patient's stomach or bowel in apposition to the abdominal wall. The packaging device (13) includes a housing (15) having a cylindrical recess (26) into which the "T" head (45) of the T-fastener (19) is loaded. The surgeon can slide the open end of the slotted needle (18) into the cylindrical recess and over the "T" head of the T-fastener, thereby effectively loading the T-fastener into the slotted needle without requiring the surgeon to touch the sharp point of the needle.

Abstract translation: T型紧固件安装套件（10）包括用于将T型紧固件（19）装载到开槽针（18）中的包装装置（13），而不需要外科医生的手接触针的尖端。 T型紧固件可以通常用于例如外科手术中，其中T型紧固件用于固定患者的胃或排便于腹壁的肠。 包装装置（13）包括具有圆柱形凹部（26）的壳体（15），T形紧固件（19）的“T”头（45）被装载到该圆柱形凹部中。 外科医生可以将开槽针（18）的开口端滑入圆柱形凹槽中并在T型紧固件的“T”头之上，从而有效地将T型紧固件装载到开缝针中，而不需要外科医生接触尖锐的 针点。

公开(公告)号：WO1994021643A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002729

申请日：1994-03-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  LULY, Jay, R.

IPC: C07D491/16

CPC classification number: C07D498/18

Abstract: Immunomodulatory macrocyclic compounds having formula (I) and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein R and R are selected such that one of R and R is hydrogen, and the other is chosen from the group consisting of: (1) -OC(=NR )-NHR ; (2) -OC(=O)-R ; and (3) -OC(=O)-NR R , (4) -OC(=O)-N(OR )R ; (5) -OC(=O)-NHNR R ; (6) -OC(=O)-NH-NHC(=O)-NR R ; (7) -OC(=O)-NH-NHS(O)2-NR R ; and (8) -OC(=O)-NH-NHC(=NR )-NR R as well as pharmaceutical compositions containing such compounds and methods for their use in immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative therapy.

Abstract translation: 具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 8和R 9被选择为使得R 8和R 9之一是氢，和 另一个选自：（1）-OC（= NR 10） - NHR 10; （2）-OC（= O）-R 11; 和（3）-OC（= O）-NR 12 R 13，（4）-OC（= O）-N（OR 14）R 12; （5）-OC（= O）-NHNR 12 R 13; （6）-OC（= O）-NH-NHC（= O）-NR 12 R 13; （7）-OC（= O）-NH-NHS（O）2 -NR 12 R 13; 和（8）-OC（= O）-NH-NHC（= NR 21）-NR 12 R 13以及含有这些化合物的药物组合物及其用于免疫抑制，抗微生物，抗真菌， 抗病毒，抗炎和抗增生治疗。

公开(公告)号：WO1994021642A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002692

申请日：1994-03-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WAGNER, Rolf ,  LULY, Jay, R. ,  OR, Yat, Sun

IPC: C07D491/16

CPC classification number: C07D498/18

Abstract: Immunomodulatory macrocyclic compounds having formula (I) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing the same, which possess immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative activity, as well as the ability to reverse chemotherapeutic drug resistance.

Abstract translation: 具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，以及含有它们的药物组合物，其具有免疫抑制，抗微生物，抗真菌，抗病毒，抗炎和抗增殖活性，以及 逆转化疗药物耐药。