公开(公告)号：WO1995001794A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007575

申请日：1994-07-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  EDWARDS, Carla ,  LARTEY, Paul, A.

IPC: A61K31/70

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II) and pharmaceutically acceptable salts thereof, wherein Y is selected form (a), (b), and (c) and X is selected from the group consisting of -C(O)-, -C(S)-, CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

Abstract translation: 具有式（II）的抗菌化合物及其药学上可接受的盐，其中Y选自（a），（b）和（c）形式，X选自-C（O） - ， - C ） - ，CH 2 - ， - CH 2 CH 2 - 和-C（CH 3）2 - ; 还公开了可用于制备上述化合物的方法和中间体，以及含有该化合物的组合物及其使用方法。

公开(公告)号：EP0707482A1

公开(公告)日：1996-04-24

申请号：EP94923344.0

申请日：1994-07-06

Applicant: ABBOTT LABORATORIES

Inventor： EDWARDS, Carla ,  LARTEY, Paul A.

IPC: A61K31 ,  A61P31 ,  C07H17

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II) and pharmaceutically acceptable salts thereof, wherein Y is selected form (a), (b), and (c) and X is selected from the group consisting of -C(O)-, -C(S)-, CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

Abstract translation: 其中Y选自（a），（b）和（c）且X选自-C（O） - ， - C（S） ） - ，CH 2 - ， - CH 2 CH 2 - 和-C（CH 3）2 - ; 也公开了用于制备上述化合物的方法和中间体，以及含有它们的组合物及其使用方法。

公开(公告)号：EP0579770A1

公开(公告)日：1994-01-26

申请号：EP92911585.0

申请日：1992-03-30

Applicant: ABBOTT LABORATORIES

Inventor： FREIBERG, Leslie A. ,  EDWARDS, Carla ,  PARIZA, Richard J. ,  NELLANS, Hugh N.

IPC: A61K31 ,  A61P1 ,  C07H17

CPC classification number: C07H17/08 ,  C07H17/00 ,  C07H17/02

Abstract: Composés de lactame macrocyclique de la formule (I) et sels pharmaceutiquement acceptables desdits composés, dans laquelle A est choisi parmi (II), (III) et (IV). Des procédés et des intermédiaires synthétiques utiles dans la préparation des composés de la présente invention, des compositions contenant lesdits composés et des méthdoes d'utilisation destinées à stimuler les mouvements contractiles des voies gastro-intestinales sont également décrits.

公开(公告)号：EP0707482B1

公开(公告)日：1999-05-26

申请号：EP94923344.9

申请日：1994-07-06

Applicant: ABBOTT LABORATORIES

Inventor： EDWARDS, Carla ,  LARTEY, Paul A.

IPC: A61K31/70 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II) and pharmaceutically acceptable salts thereof, wherein Y is selected form (a), (b), and (c) and X is selected from the group consisting of -C(O)-, -C(S)-, CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

公开(公告)号：EP0579770B1

公开(公告)日：1996-06-26

申请号：EP92911585.5

申请日：1992-03-30

Applicant: ABBOTT LABORATORIES

Inventor： FREIBERG, Leslie A. ,  EDWARDS, Carla ,  PARIZA, Richard J. ,  NELLANS, Hugh N.

IPC: A61K31/70 ,  C07H17/08

CPC classification number: C07H17/08 ,  C07H17/00 ,  C07H17/02

Abstract: Macrocyclic lactam compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A is selected from (II), (III) and (IV); also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.