公开(公告)号：WO2007123518A1

公开(公告)日：2007-11-01

申请号：PCT/US2006/014988

申请日：2006-04-21

Applicant: CEDARS-SINAI MEDICAL CENTER ,  UNIVERSITY OF SOUTHERN CALIFORNIA ,  PAPAIOANNOU, Thanassis ,  FANG, Qiyin ,  JO, Javier, A. ,  MARCU, Laura ,  SHUNG, K., Kirk

Inventor： PAPAIOANNOU, Thanassis ,  FANG, Qiyin ,  JO, Javier, A. ,  MARCU, Laura ,  SHUNG, K., Kirk

IPC: A61B5/00 ,  A61B5/05 ,  G01J3/50

CPC classification number: G01J3/02 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/02007 ,  A61B5/6852 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/445 ,  A61B8/4461 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0264 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/10

Abstract: The apparatus and methods described herein enable an operator to simultaneously collect images and spectroscopic information from a region(s) of interest using a multiple modality imaging and/or spectroscopic probe, configured as a catheter, endoscope, microscope, or hand held probe. The device may incorporate, for example, an ultrasonic transducer and a fiber optic probe to translate images and spectra. The apparatus and methods may be used in any suitable cavity, for example, the vascular system of a mammal.

Abstract translation: 本文描述的装置和方法使得操作者能够使用配置为导管，内窥镜，显微镜或手持探针的多模式成像和/或光谱探针同时从感兴趣的区域收集图像和光谱信息。 该装置可以包括例如超声波换能器和光纤探针以平移图像和光谱。 该装置和方法可以用于任何合适的空腔，例如哺乳动物的血管系统。

公开(公告)号：WO2007082054A2

公开(公告)日：2007-07-19

申请号：PCT/US2007000805

申请日：2007-01-10

Applicant: SUNRISE TELECOM INC ,  ZENG KE-CAI ,  CHANG PAUL ,  BRENDEL JUERGEN

Inventor： ZENG KE-CAI ,  CHANG PAUL ,  BRENDEL JUERGEN

IPC: G01B9/02

CPC classification number: G01J3/26 ,  G01J3/02 ,  G01J3/0286 ,  G01J3/28 ,  G01J2003/2866 ,  G01M11/331 ,  G01M11/336 ,  G01M11/338 ,  H04B10/07951

Abstract: An optical signal measurement system [1200] provides [1202] a tunable optical filter [402]. An unknown optical signal [628] is scanned [1204] through the tunable optical filter [402]. The wavelength and chromatic dispersion values of the unknown optical signal [628] scanned through the tunable optical filter [402] are measured [1206] by operating the tunable optical filter [402] in a scanning mode for at least one of OSA and PMD measurements, and in a stepping mode for CD measurements. The wavelength and the dispersion values in the unknown optical signal [628] are specified [1208].

Abstract translation: 光信号测量系统[1200]提供可调光滤波器[402]。 通过可调谐滤光器[402]扫描未知光信号[620]。 通过在OSA和PMD测量中的至少一个的扫描模式中操作可调谐光学滤波器[402]来测量通过可调谐滤光器[402]扫描的未知光信号的波长和色散值[1206] ，并以CD测量的步进模式。 未知光信号[628]中的波长和色散值被指定[1208]。

公开(公告)号：WO2007007165A2

公开(公告)日：2007-01-18

申请号：PCT/IB2006001906

申请日：2006-07-11

Applicant: DE BEERS CONS MINES LTD ,  HILL GRAEME JOHN ,  LABOTSKI ALEXEII UCAMEL ,  GREEN JEREMY JAMES ,  KRUGER MARTIN JACOBUS ,  VIRANNA NARENDRA BALAGURU

Inventor： LABOTSKI ALEXEII UCAMEL ,  GREEN JEREMY JAMES ,  KRUGER MARTIN JACOBUS ,  VIRANNA NARENDRA BALAGURU

IPC: G01N21/85 ,  G01N21/35

CPC classification number: G01J3/28 ,  B07C5/3425 ,  G01J3/02 ,  G01J3/0286 ,  G01J3/108 ,  G01N21/85 ,  G01N21/87

Abstract: An infrared spectral system (10) for identifying target mineral grain particles within a group of mineral grains (12) is disclosed. In an example embodiment, the system (10) comprises a conveyor belt (20) for carrying the group of mineral grains (12), at least one infrared excitation module (16) that includes means (40) for providing infrared radiation to the group of mineral grains (12) on the conveyor belt (20), at least one infrared collection module (32) for collecting the reflected infrared radiation from the group of mineral grains (12) on the conveyor belt (20), processing means (72) for determining the location of target mineral grain particles on the conveyor belt (20), and target particle extraction means for picking the target particles based on the processing means' determined location of target particles. In an example embodiment, the means (40) for providing infrared radiation to the particles on the conveyor belt includes a heater element (46) located within a heater holder (42). In a second example embodiment, particles are presented as a batch to a spectral imaging system (100), and target particles are picked by a robotic system.

Abstract translation: 公开了用于识别一组矿物颗粒（12）内的目标矿物颗粒的红外光谱系统（10）。 在示例实施例中，系统（10）包括用于承载矿物颗粒组（12）的传送带（20），至少一个红外激励模块（16），其包括用于向该组提供红外辐射的装置 （20）上的矿物颗粒（12），至少一个用于收集来自传送带（20）上的矿物颗粒群（12）的反射红外辐射的至少一个红外线收集模块（32），处理装置（72 ），用于确定传送带（20）上的目标矿物颗粒的位置;以及目标颗粒提取装置，用于基于处理装置确定的目标颗粒的位置来拾取目标颗粒。 在示例实施例中，用于向传送带上的颗粒提供红外辐射的装置（40）包括位于加热器保持器（42）内的加热器元件（46）。 在第二示例实施例中，粒子作为批次呈现给光谱成像系统（100），并且目标粒子由机器人系统拾取。

公开(公告)号：WO2006065267A1

公开(公告)日：2006-06-22

申请号：PCT/US2005/014716

申请日：2005-04-30

Applicant: AHURA CORPORATION

Inventor： DARYOOSH, Vakhshoori ,  PEILI, Chen ,  PEIDONG, Wang ,  MASUD, Azimi

IPC: G01J3/28

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0286

Abstract: A spectrometer comprising a collimating element for receiving input light and collimating the same, a dispersive optical element receiving light from the collimating element and dispersing the same and a focusing element for receiving light from the dispersive optical element and focusing the same a detector assembly wherein, where the wavelength dispersion of the dispersed light extends in the x-y direction, the collimating element and the focusing element are formed so as maintain the desired optical parameters the x-y plane while having a reduced size in z direction.

Abstract translation: 一种光谱仪，包括用于接收输入光并准直其的准直元件，分散光学元件，其从准直元件接收光并将其分散，并且聚焦元件用于从分散光学元件接收光并将其聚焦在检测器组件上， 其中分散光的波长色散沿xy方向延伸，准直元件和聚焦元件形成为使得所需的光学参数保持为xy平面，同时在z方向上具有减小的尺寸。

公开(公告)号：WO2005044269A1

公开(公告)日：2005-05-19

申请号：PCT/US2004/013253

申请日：2004-04-28

Applicant: CELGENE CORPORATION ,  ZELDIS, Jerome, B.

Inventor： ZELDIS, Jerome, B.

IPC: A61K31/445

CPC classification number: A61K38/185 ,  A61K31/454 ,  A61K31/522 ,  A61K31/545 ,  A61K31/557 ,  A61K31/56 ,  A61K38/21 ,  A61K38/27 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/501 ,  G01J3/524 ,  Y10S514/912 ,  A61K2300/00

Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Abstract translation: 公开了治疗，预防和/或治疗黄斑变性的方法。 具体实施方案包括单独或与第二活性剂和/或手术组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

公开(公告)号：WO2003093776A1

公开(公告)日：2003-11-13

申请号：PCT/US2003/010335

申请日：2003-04-04

Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI

Inventor： LARSEN, David, W. ,  XU, Zhi ,  GARVER, Wayne

IPC: G01J3/427

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42

Abstract: One aspect of the invention is a spectrophotometer detection circuit (189, 934, 1031). In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing (112, 900, 1000) and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing (900, 1000) with a hollowed portion (900a, 1000a) defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments.

Abstract translation: 本发明的一个方面是分光光度计检测电路（189,934,1031）。 在本发明的这个方面，在当前模式下，归因于参考和采样光束的电流被消除。 检测电路产生与电流差成比例的第一电压和与参考或采样光束之一成比例的第二电压。 两种电压均可用于同时测量和分析。 本发明的另一方面涉及热稳定性。 根据本发明，在壳体（112,900,1000）和光学系统部件之间建立导热性以促进平衡。 另一个优选实施例具有整体固体金属壳体（900,1000），其具有限定为安装和放置光学系统部件的中空部分（900a，1000a）。 识别和识别分光光度计中的重要噪声源形成本发明的一个方面，其有利于优选实施例中的特征和特征的组合。

公开(公告)号：WO0194990A3

公开(公告)日：2003-08-14

申请号：PCT/US0117833

申请日：2001-06-01

Applicant: LIGHTCHIP INC

Inventor： CAPIELLO GREGORY G ,  SOKOLSKIY MIKHAIL N ,  DUECK ROBERT H

IPC: G01J3/02 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G02B5/18 ,  G02B6/34 ,  G02B6/38 ,  G02B7/00 ,  G02B7/02 ,  G02B27/10 ,  H04B10/08 ,  H04B10/213 ,  H04J14/02 ,  G02B6/293

CPC classification number: G02B6/29397 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2803 ,  G02B5/18 ,  G02B6/2931 ,  G02B6/2938 ,  G02B6/3807 ,  G02B7/008 ,  G02B7/028 ,  G02B27/1073 ,  G02B27/1086 ,  G02B27/123 ,  G02B27/126 ,  H04B10/077 ,  H04B10/07955 ,  H04J14/02 ,  H04J14/0201

Abstract: A diffraction grating for optical communication is disclosed. The diffraction grating includes a substrate and a reflective material adjacent the substrate, wherein one or more input optical signals incident the reflective material is diffracted into one or more output optical signals over a wavelength range of at least approximately 30nm, within which the diffraction grating is substantially polarization insensitive.

Abstract translation: 公开了一种用于光通信的衍射光栅。 衍射光栅包括衬底和与衬底相邻的反射材料，其中入射到反射材料的一个或多个输入光信号在至少约30nm的波长范围内被衍射成一个或多个输出光信号，其中衍射光栅是 基本上极化不敏感。

公开(公告)号：WO0196910A3

公开(公告)日：2002-05-10

申请号：PCT/US0118085

申请日：2001-06-05

Applicant: LIGHTCHIP INC

Inventor： BEATTIE JIM ,  TURNER IAN ,  ZHU NINGHUI

IPC: G01J3/14 ,  G01J3/28 ,  G02B7/00 ,  H04J14/02 ,  G02B6/34

CPC classification number: G01J3/14 ,  G01J3/0202 ,  G01J3/0286 ,  G01J3/2803 ,  G02B7/008 ,  H04J14/02

Abstract: A wavelength division multiplexer (WDM) including a support structure that is coupled to at least one optical component. A diffraction grating is optically coupled to at least one optical component coupled to the at least one optical component. A frame is coupled to the diffraction grating. Pins may be coupled between the support structure and the frame to substantially thermally isolate the support structure from the frame. The pins may be substantially geometrically equally spaced and have approximately the same exposed length extending from the lens barrel. The pins may have the same coefficient of thermal expansion as the support structure.

Abstract translation: 一种波分复用器（WDM），包括耦合到至少一个光学部件的支撑结构。 衍射光栅光耦合到耦合到至少一个光学部件的至少一个光学部件。 一个框架耦合到衍射光栅。 引脚可以联接在支撑结构和框架之间，以将支撑结构与框架基本上热隔离。 销可以基本上几何等间隔，并且具有从透镜镜筒延伸的大致相同的暴露长度。 销可以具有与支撑结构相同的热膨胀系数。

公开(公告)号：WO02025934A2

公开(公告)日：2002-03-28

申请号：PCT/EP2001/011027

申请日：2001-09-24

IPC: G01J3/02 ,  G01J3/28 ,  H04N5/335

CPC classification number: G01J3/02 ,  G01J3/0286 ,  G01J3/2803 ,  H04N5/341 ,  H04N5/374 ,  H04N5/3765

Abstract: The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and columes are in the sub-nanoliter range). Such "intelligent sensing" allows higher data quality and reliability, higher measurement and analysis throughput and lower cost. The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed. Through real-time adaptive control of sensors, chemical/opto-mechanical/opto-electronic processes and other components during the measurement process, consistently higher quality results and higher reliability are achieved. This invention furthermore includes an improved image sensor architecture that enables very intra-array dynamic range at fast frame rates and low noise performance.

Abstract translation: 用于实时光学测量和伺服检测的设备和方法，可提高效率。 本发明的方法适用于诸如光谱学，显微术，生物学分析，小型化过程和反应（例如微/纳米板，微格式和 微采样的，微通道和微流体，其尺寸在微米尺度和体积进行评估是在子纳升的电平）的芯片上的化学上芯片，实验室。 这样的 / =提供了卓越的数据可用性和质量，以更低的成本获得了更好的测量和性能。 这些方法使用实时数字信号的快速自适应处理并直接控制检测数据的点。 通过在测量过程中利用探测器，化学，光机械和光电子过程及其他部件的自适应实时控制，可以获得显着更好的结果和可行性。 本发明还涉及一种改进的图像检测器体系结构，其在快速帧速率和降低的噪声下提供采样内的非常动态的范围。

公开(公告)号：WO01095537A2

公开(公告)日：2001-12-13

申请号：PCT/US2001/017835

申请日：2001-06-01

IPC: G01J3/02 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G02B5/18 ,  G02B6/34 ,  G02B7/00 ,  G02B7/02 ,  G02B27/10 ,  H04B10/08 ,  H04B10/213 ,  H04J14/02 ,  H04J14/00

CPC classification number: H04J14/02 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0286 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2803 ,  G02B5/18 ,  G02B6/2931 ,  G02B6/2938 ,  G02B6/29398 ,  G02B7/008 ,  G02B7/028 ,  G02B27/1073 ,  G02B27/1086 ,  G02B27/123 ,  G02B27/126 ,  H04B10/077 ,  H04B10/07955 ,  H04J14/0201 ,  H04J14/0217

Abstract: A wavelength division multiplexer/demultiplexer (WDM) for use in an optical network and in an optical performance monitor that minimizes increases in insertion losses over temperature variations. The WDM has a structure for holding at least one optical component. A diffraction grating assembly having a substrate is held in relation to the at least one optical component by the structure. A lens assembly having a focal length is held in relation to the at least one optical component. The coefficient of thermal expansion of the lens assembly and structure are approximately equal. The lens assembly is constructed from a material chosen to minimize its variance in focal length over temperature. The grating assembly has an angular dispersion that changes with temperature and the product of the focal length and angular dispersion remains constant over temperature. The WDM further comprises a prism having a change in index of refraction with temperature that is approximately equal to a negative of a coefficient of thermal expansion of the substrate. The substrate has a coefficient of thermal expansion approximately equal to a negative of a coefficient of thermal expansion of air.

Abstract translation: 一种用于光网络和光学性能监视器中的波分复用器/解复用器（WDM），其使得在温度变化上的插入损耗增加最小化。 WDM具有用于保持至少一个光学部件的结构。 通过该结构，具有基板的衍射光栅组件相对于至少一个光学部件保持。 相对于至少一个光学部件保持具有焦距的透镜组件。 透镜组件和结构的热膨胀系数近似相等。 透镜组件由选择为使其焦距在温度上的变化最小化的材料构成。 光栅组件具有随温度变化的角度色散，并且焦距和角度色散的乘积在温度上保持恒定。 WDM还包括棱镜，其折射率随着温度的变化大致等于衬底的热膨胀系数的负值。 基板的热膨胀系数近似等于空气的热膨胀系数的负值。