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    Crosslinkable skin care adhesive
    32.
    发明专利
    Crosslinkable skin care adhesive 有权
    可交联皮肤粘合剂

    公开(公告)号：JP2005325101A

    公开(公告)日：2005-11-24

    申请号：JP2005114273

    申请日：2005-04-12

    Applicant: Kosumedei:Kk ,  Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社 ,  有限会社コスメディ

    Inventor： KAMIYAMA FUMIO ,  KEN EISHIYUKU ,  KAWAMURA NAOHISA ,  SAWADA HIDENORI

    IPC: A61K9/70 ,  A61F13/02 ,  A61K8/02 ,  A61K47/32 ,  A61K7/00

    Abstract: PROBLEM TO BE SOLVED: To provide a composition for suitably producing a crosslinkable skin care adhesive that is slight in irritancy, has good tackiness and releasability for human skin, is suitable for medical use or cosmetic use and has good storability. SOLUTION: The crosslinkable skin care adhesive is produced from the composition that comprises 100 pts. mass of an acrylic copolymer(copolymer A) with a (meth)acrylic alkyl ester as the main constituent containing 3-45 mass% of a diacetoneacrylamide as the essential constituent and containing no free carboxy group and 0.1-30 pts. mass of an acrylic copolymer(copolymer B) with a (meth)acrylic alkyl ester as the main constituent containing on the side chain primary amino group and/or carboxyhydrazido group and containing no free carboxy group. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：为了提供适合生产刺激性轻的具有良好的粘合性和脱皮性的交联性护肤胶粘剂的组合物，适用于医疗用途或化妆品用途，并具有良好的保存性。

    解决方案：可交联护肤粘合剂由包含100个肽的组合物制备。 以（甲基）丙烯酸烷基酯为主要成分的丙烯酸共聚物（共聚物A）的质量含有3-45质量％的双丙酮丙烯酰胺作为必需成分并且不含游离羧基和0.1-30重量份。 具有（甲基）丙烯酸烷基酯作为主要成分的丙烯酸共聚物（共聚物B）的质量含有侧链伯氨基和/或羧酰肼基并且不含游离羧基。 版权所有（C）2006，JPO＆NCIPI

    Reserver type plaster
    34.
    发明专利
    Reserver type plaster 审中-公开
    储备式塑料

    公开(公告)号：JP2003063954A

    公开(公告)日：2003-03-05

    申请号：JP2001254897

    申请日：2001-08-24

    Applicant: Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社

    Inventor： NAKAJIMA NORIKO ,  YAMAUCHI HITOSHI

    IPC: A61K9/70 ,  A61K47/02 ,  A61K47/30 ,  C09J7/02 ,  C09J11/04 ,  C09J109/06 ,  C09J133/08

    Abstract: PROBLEM TO BE SOLVED: To provide a reserver type plaster, enableing a drug to be percutaneously persistently absorbed in a skin through application thereto, and hence exhibiting a therapeutic effect, and improving the releasability of the drug, an absorption promoter or the like from an adhesive layer.
    SOLUTION: A non-permeable support layer, a drug-permeable layer for controlling the releasability, an adhesive layer and a release layer are subsequently laminated on the drug in the reserver type plaster. Further, the reserver type plaster is provided with a drug storage layer which is formed through sealing the drug between the support layer and the layer for controlling the releasability. The adhesive layer has a fine particle inorganic base or a fine particle water soluble polymer, which is uniformly dispersed in the adhesive layer. The bonding strength between the polymers of the adhesive is weakened through mixing the inorganic salts or the water-soluble polymer into the adhesive layer, and gaps are partially formed in the adhesive layer through dissolving the inorganic salts or the water-soluble polymer therein, so that the drug or the absorption promoter is promoted to pass the adhesive layer.
    COPYRIGHT: (C)2003,JPO

    Abstract translation: 要解决的问题：提供一种储备型石膏，使药物通过施用于皮肤而经皮持续吸收，因此呈现治疗效果，并且提高药物，吸收促进剂等的释放性 粘合剂层。 解决方案：随后将不可渗透的支撑层，用于控制释放性的药物可渗透层，粘合剂层和释放层层压在储备型膏药中的药物上。 此外，储存型膏药设置有药物储存层，其通过将药物密封在支撑层和用于控制脱模性的层之间而形成。 粘合剂层具有均匀分散在粘合剂层中的细颗粒无机碱或细颗粒水溶性聚合物。 通过将无机盐或水溶性聚合物混合到粘合剂层中，使粘合剂的聚合物之间的结合强度降低，并且通过将无机盐或水溶性聚合物溶解在粘合层中部分地形成间隙，因此 促进药物或吸收促进剂通过粘合剂层。

    Hormone-containing preparation composition for external use
    36.
    发明专利
    Hormone-containing preparation composition for external use 失效
    用于外用的含HORMONE的制备组合物

    公开(公告)号：JPH11279063A

    公开(公告)日：1999-10-12

    申请号：JP8669498

    申请日：1998-03-31

    Applicant: Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社

    Inventor： KUME HIROKO ,  YAMAUCHI HITOSHI

    IPC: A61K9/08 ,  A61K31/56 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition which shows excellent percutaneous absorbability, stability and safety by blending prasterone sulfate with terpenes, a monofatty acid glyceride or the like.
    SOLUTION: This composition is obtained by blending (A) prasterone sulfate (e.g. prasterone sodium sulfate or the like) with one kind or more two kinds selected from (B) a terpene (e.g. L-menthol, geraniol or the like), (C) a N-alkyl-2- pyrrolidone (e.g. N-methyl-2-pyrrolidone or the like) and (D) a monofatty acid glyceride (e.g. glycerin monocaprate or the like). On the above composition, it is favorable that the total content of the components B-D is 0.1-30 wt.%. The above composition can be prepared in forms of semisolid preparations, e.g. ointment, cream, gel or the like, patches, e.g. cataplasm, plaster or the like, and solutions, e.g. liniment, emulsion, lotion or the like.
    COPYRIGHT: (C)1999,JPO

    Abstract translation: 要解决的问题：通过将硫酸蓖麻脂与萜烯，单糖酸甘油酯等混合来获得显示优异的经皮吸收性，稳定性和安全性的主题组合物。 溶液：该组合物通过将（A）硫酸假山梨醇（例如硫酸假山梨醇等）与选自（B）萜烯（例如L-薄荷醇，香叶醇等）中的一种或两种以上（C ）N-烷基-2-吡咯烷酮（例如N-甲基-2-吡咯烷酮等）和（D）单糖酸甘油酯（例如甘油单癸酸酯等）。 在上述组成中，组分B-D的总含量为0.1-30重量％是有利的。 上述组合物可以半固体制剂形式制备，例如 软膏，霜剂，凝胶等，补片，例如， 泥敷剂，石膏等，以及溶液，例如， 搽剂，乳液，洗剂等。

    Pharmaceutical composition for external application and adhesive skin patch
    37.
    发明专利
    Pharmaceutical composition for external application and adhesive skin patch 审中-公开
    用于外用和胶粘皮肤的药物组合物

    公开(公告)号：JP2008163017A

    公开(公告)日：2008-07-17

    申请号：JP2007316286

    申请日：2007-12-06

    Applicant: Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社

    Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SUGAYA CHIE ,  SAKURAI NORIAKI

    IPC: A61K31/192 ,  A61K9/70 ,  A61K47/12 ,  A61K47/22 ,  A61K47/44

    CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405

    Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for external application and an adhesive skin patch which can improve the releasability, transdermal absorbability, and stability of loxoprofen and its salt and can inhibit the aggravation of irritation to the skin.
    SOLUTION: The adhesive skin patch comprises a support, and a self-adhesive layer laminated on the support, wherein this adhesive layer contains a pharmaceutical composition for external application. This pharmaceutical composition for external application comprises loxoprofen or its pharmacologically acceptable salt, an auxiliary component having a hydroxy group in the molecule, and a pyrrolidone compound. Preferably, the self-adhesive layer further comprises hydrogenated oil.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供外用药物组合物和粘合性皮肤贴剂，其可以改善洛索洛芬及其盐的释放性，透皮吸收性和稳定性，并且可以抑制刺激对皮肤的加重。 粘合剂皮肤贴剂包括载体和层压在载体上的自粘层，其中该粘合剂层含有用于外用的药物组合物。 该外用药物组合物包括洛索洛芬或其药理学上可接受的盐，分子中具有羟基的辅助成分和吡咯烷酮化合物。 优选地，自粘层还包含氢化油。 版权所有（C）2008，JPO＆INPIT

    Flexibility measuring method and pasting agent
    38.
    发明专利
    Flexibility measuring method and pasting agent 有权
    灵活性测量方法和抛光剂

    公开(公告)号：JP2008039618A

    公开(公告)日：2008-02-21

    申请号：JP2006215081

    申请日：2006-08-07

    Applicant: Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社

    Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SAITO TAKASHI

    IPC: G01N3/00 ,  A61K9/70

    Abstract: PROBLEM TO BE SOLVED: To provide a flexibility measuring method which enables a proper evaluation of the flexibility required in a pasting agent.
    SOLUTION: The flexibility measuring method is constituted so as to measure the flexibility of the pasting agent 20 using a mount stand 10 having an almost flat surface 11 and has a preparation process for bonding the pasting agent 20 to an outer edge part 111 so as to extend the extension part 24 of the pasting agent 20 outward and a measuring process for measuring the suspending distance of the extension part 24 from the height of the surface 11. The measuring process successively measures the suspending distances D
    1 and D
    2 of the extension part 24 on the sides of a plaster layer 22 and a support 21.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种灵活性测量方法，其能够适当评估粘贴剂所需的柔性。 ＆lt; P＆gt;解决方案：柔性测量方法被构造成使用具有几乎平坦的表面11的安装台10测量粘贴剂20的柔性，并且具有将粘贴剂20粘合到外边缘部111的制备工艺 以便将粘贴剂20的延伸部分24向外延伸，以及用于测量延伸部分24的悬挂距离与表面11的高度的测量过程。测量过程连续测量悬挂距离D 1 < / SB>和D 2 在石膏层22和支撑体21的侧面上。（C）2008，JPO＆INPIT

    Patches and process for production of patches
    39.
    发明专利
    Patches and process for production of patches 有权
    配件和生产过程的过程

    公开(公告)号：JP2007137876A

    公开(公告)日：2007-06-07

    申请号：JP2006284703

    申请日：2006-10-19

    Applicant: Saitama Daiichi Seiyaku Kk ,  埼玉第一製薬株式会社

    Inventor： NAKAMURA NORIKO ,  GOTOU MOTOAKI

    IPC: A61K31/4468 ,  A61K9/70 ,  A61P29/00

    Abstract: PROBLEM TO BE SOLVED: To provide safe and non-reservoir type patches with improved adhesiveness and following property with reduced irritation to skin that can be easily produced, and having an excellent percutaneous absorbability of fentanyl. SOLUTION: The patches are equipped with a support body having an adhesive layer further containing fentanyl on the support body. The adhesive layer is formed by copolymerization of an alkyl (meth)acrylate as a main component and 3-45 mass% of diacetone acrylamide to the copolymer and formed by polymerization of 100 pts.mass of an acrylic copolymer (A) substantially containing no free carboxyl group and the alkyl (meth)acrylate as a main component, and has a primary amino group and/or a carboxyhydrazide group in the side chain, and a cross-linking structure with 0.1-30 pts.mass of an acrylic copolymer (B) substantially containing no free carboxyl group. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供具有改善的粘附性和随后特性的安全和非储存型贴剂，对易于产生的对皮肤的刺激性降低，并且具有优异的芬太尼经皮吸收能力。 解决方案：贴片配备有支撑体，其具有在支撑体上还含有芬太尼的粘合剂层。 作为主要成分的（甲基）丙烯酸烷基酯和3-45质量％的双丙酮丙烯酰胺共聚而形成粘合剂层，通过聚合100重量份的基本上不含游离的丙烯酸共聚物（A） 羧基和（甲基）丙烯酸烷基酯作为主要成分，并且在侧链中具有伯氨基和/或羧酰肼基团，和具有0.1-30质量份丙烯酸共聚物（B ）基本上不含游离羧基。 版权所有（C）2007，JPO＆INPIT

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