公开(公告)号：KR3001227610000S

公开(公告)日：1992-02-06

申请号：KR3019910001641

申请日：1991-02-09

Applicant: 주식회사대성미생물연구소

Designer： 이동규

公开(公告)号：KR100045632B1

公开(公告)日：1991-11-01

申请号：KR1019890015450

申请日：1989-10-26

Applicant: 주식회사대성미생물연구소

Inventor： 이동규

IPC: C12N1/20

公开(公告)号：KR1020150142788A

公开(公告)日：2015-12-23

申请号：KR1020140070941

申请日：2014-06-11

Applicant: 전남대학교산학협력단 ,  주식회사대성미생물연구소

Inventor： 정성주 ,  김경 ,  김예지

IPC: A61K39/09 ,  A61K39/02 ,  A61K31/01 ,  A61P31/12

CPC classification number: A61K39/09 ,  A61K31/01 ,  A61K39/02

Abstract: 본발명은스쿠티카충백신조성물에관한것이다. 상기와같은본 발명에따르면, 불화화된그람양성세균, 바람직하게는불화화된스트렙토코커스(streptococcus)속세균을면역보조제로포함하는스쿠티카충에대한백신조성물및 이의제조방법을제공함으로써, 스쿠티카충에대한우수한면역효과를나타내어어류의스쿠티카충감염을효과적으로예방또는치료할수 있는있을뿐만아니라국내양식넙치에서스쿠티카충감염으로인해심각한경제적손실이야기되고있는점을고려해볼 때경제적인방법으로스쿠티카충으로인한경제적손실을최소화할수 있는효과가있다.

Abstract translation: 本发明涉及一种Scuticociliatida附属疫苗组合物。 根据本发明，提供了一种针对鳞翅目的疫苗组合物及其制造方法，其包含氟化革兰氏阳性菌，期望氟化的链球菌作为免疫佐剂，从而通过代表优异的方式有效地预防或治疗鱼类中的鳞状毛球菌感染 免疫学效应，通过考虑由于国内水产养殖鲽鱼中的鳞翅目感染引起的严重经济损失，经济方法减少了Scuticociliatida附着的经济损失。

公开(公告)号：KR1020070080216A

公开(公告)日：2007-08-09

申请号：KR1020070009081

申请日：2007-01-29

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  조항원 ,  이원준

IPC: A61K31/7048 ,  A61K31/165 ,  A61K31/04 ,  A61P31/00

CPC classification number: A61K31/7048 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/14 ,  A61K31/165 ,  A61K2300/00

Abstract: An optimum antibiotic complex composition containing florfenicol is provided to offer significantly increased antibacterial effect compared to other antibiotic complex composition of macrolide antibiotic materials by mixing the florfenicol with tyrosine with excellent inhibitory effect of pathogenic microorganism of animal. The antibiotic complex composition for animal is characterized in that it consists of tyrosine and florfenicol in a weight ratio of 1:1.5-6. The antibiotic complex composition is formulated into an injection agent, an oral administration liquid agent, powder or granule. The injection agent or the oral administration liquid agent is prepared by using glycerol formal, N-methyl-2 pyrrolidone, or mixture thereof as a solvent.

Abstract translation: 提供含有氟苯尼考的​​最佳抗生素复合物组合物，通过将氟苯尼考与酪氨酸混合，具有优异的动物病原微生物抑制作用，与​​大环内酯抗生素材料的其他抗生素复合物组合物相比，具有显着增加的抗菌作用。 用于动物的抗生素复合物组合物的特征在于其由酪氨酸和氟苯尼考组成，重量比为1：1.5-6。 将抗生素复合物组合物配制成注射剂，口服给药液剂，粉剂或颗粒剂。 注射剂或口服液剂通过使用甘油形式，N-甲基-2-吡咯烷酮或其混合物作为溶剂来制备。

公开(公告)号：KR100403571B1

公开(公告)日：2003-11-01

申请号：KR1019990056277

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/715

Abstract: PURPOSE: A complex antibiotic composition for animal showing growth-stimulation effect is provided, which contains iron and chitosan-oligosaccharide in the ratio of 1:5-5:1, so that it is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, and can be used instead of expensive antibiotics, therefore it saves production cost and minimizes residue of medicine in animal's body. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal showing growth-stimulation effect is comprised of: mixing iron(iron dextran) and aminoglycosides antibiotics; mixing chitosan-oligosaccharide(OCHT: molecular weight range is 200-99,000, and distribution of 1-16 sugar is more than 55%) and the prepared compound till the mixing ratio of iron and chitosan-oligosaccharide to be in the ratio of 1:5-5:1, and gaining the complex antibiotic composition for animal showing growth-stimulation effect. The complex antibiotic composition can be prepared in the form of an injection or a solution for animal.

Abstract translation: 目的：本发明提供一种复合抗生素组合物，具有生长刺激作用，含有铁与壳聚糖 - 寡糖的比例为1：5-5：1，可用于治疗和预防家畜细菌性疾病 可用于替代昂贵的抗生素，从而节省生产成本，减少动物体内药物残留。 组成：用于制备显示生长刺激作用的动物的复合抗生素组合物的方法包括：混合铁（葡聚糖铁）和氨基糖苷类抗生素; 混合壳聚糖 - 寡糖（OCHT：分子量范围为200-99,000，并且1-16糖的分布大于55％）和所制备的化合物直至铁和壳聚糖 - 寡糖的混合比例为1： 5-5：1，并获得动物复合抗生素组合物，表现出生长刺激作用。 复合抗生素组合物可以以注射剂或动物溶液的形式制备。

公开(公告)号：KR100371091B1

公开(公告)日：2003-02-07

申请号：KR1019990056275

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/7008

Abstract: PURPOSE: A composite antibiotic composition for animal feeding containing an aminoglycoside-based antibiotic and chitosan-oligosaccharide and exerting synergistic antibacterial activity in mixing is provided, which can be used as an agent for preventing and treating a bacterially caused disease of an animal and an immunostimulating agent. CONSTITUTION: The composite antibiotic composition for animal feeding contains an aminoglycoside-based antibiotic such as gentamicin and chitosan-oligosaccharide in a ratio of 1:5 to 5:1. The chitosan-oligosaccharide has a molecular weight of 2,000,000 to 150,000 and a distribution of 1 to 16 saccharide of 45% or more.

Abstract translation: 目的：提供一种用于动物饲养的复合抗生素组合物，其含有氨基糖苷类抗生素和壳聚糖 - 寡糖，并在混合时发挥协同抗菌活性，其可用作预防和治疗动物细菌引起的疾病和免疫刺激 剂。 组成：用于动物饲养的复合抗生素组合物含有比例为1：5至5：1的基于氨基糖苷的抗生素，例如庆大霉素和壳聚糖 - 寡糖。 壳聚糖 - 寡糖的分子量为200万〜150,000，糖的分布为1〜16个糖为45％以上。

公开(公告)号：KR1020020076434A

公开(公告)日：2002-10-11

申请号：KR1020010016262

申请日：2001-03-28

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈

IPC: A61K38/00

Abstract: PURPOSE: An immunostimulating agent containing purified protein of Bordetella pertussis together with a cell wall of a biomass of Staphylococcus aureus Cowan 1 or secretory protein is provided which can reduce the amount of antibiotics used to treat mastitis and hygienical problems such as remaining of antibiotics in milk. CONSTITUTION: The immunostimulating agent contains dead biomass or purified protein of Staphylococcus aureus Cowan 1, purified protein of Bordetella pertussis(ATCC 9797), wherein the immunostimulating agent has efficacy of reducing the number of somatic cells of livestock such as dairy cattle. For example, 10ml immunostimulating agent contains 10mg dead biomass of Staphylococcus aureus Cowan 1, 200 microgram inactivated secretory lethal toxin of Staphylococcus aureus Cowan 1, 200 microgram inactivated secretory lethal toxin of Bordetella pertussis(ATCC 9797) and a suitable amount of an excipient(10% nonfat dry milk).

Abstract translation: 目的：提供含有百日咳博德特氏菌纯化蛋白的免疫刺激剂以及金黄色葡萄球菌Cowan 1或分泌蛋白的生物量的细胞壁，其可以减少用于治疗乳腺炎的抗生素的量和卫生问题，例如在牛奶中残留抗生素 。 构成：免疫刺激剂含有金黄色葡萄球菌Cowan 1的死生物量或纯化蛋白，百日咳博德特氏菌（ATCC 9797）的纯化蛋白，其中免疫刺激剂具有降低家畜如牛奶的体细胞数量的功效。 例如，10ml免疫刺激剂含有10mg金黄色葡萄球菌Cowan的死亡生物质1，200微克灭活的金黄色葡萄球菌Cowan1的200微克灭活的分泌致死毒素，百日咳博德特氏菌（ATCC 9797）200微克灭活的分泌致死毒素和适量的赋形剂（10 ％ 脱脂奶粉）。

公开(公告)号：KR1020010058415A

公开(公告)日：2001-07-06

申请号：KR1019990056277

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/715

Abstract: PURPOSE: A complex antibiotic composition for animal showing growth-stimulation effect is provided, which contains iron and chitosan-oligosaccharide in the ratio of 1:5-5:1, so that it is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, and can be used instead of expensive antibiotics, therefore it saves production cost and minimizes residue of medicine in animal's body. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal showing growth-stimulation effect is comprised of: mixing iron(iron dextran) and aminoglycosides antibiotics; mixing chitosan-oligosaccharide(OCHT: molecular weight range is 200-99,000, and distribution of 1-16 sugar is more than 55%) and the prepared compound till the mixing ratio of iron and chitosan-oligosaccharide to be in the ratio of 1:5-5:1, and gaining the complex antibiotic composition for animal showing growth-stimulation effect. The complex antibiotic composition can be prepared in the form of an injection or a solution for animal.

Abstract translation: 目的：提供一种具有生长刺激作用的动物复合抗生素组合物，含有比例为1：5-5：1的铁和壳聚糖寡糖，因此可用于治疗和预防家畜的细菌性疾病 和贫血，可以代替昂贵的抗生素使用，从而节省生产成本，并最大限度地减少动物体内的药物残留。 构成：制备复合抗生素组合物的方法，显示生长刺激作用包括：混合铁（葡聚糖铁）和氨基糖苷类抗生素; 混合壳聚糖 - 低聚糖（OCHT：分子量范围为200-99,000，1-16糖分配超过55％），制备的化合物直至铁和壳聚糖 - 低聚糖的混合比例为1： 5-5：1，获得复合抗生素组合物，显示出生长刺激作用。 复合抗生素组合物可以以注射剂或动物溶液的形式制备。

公开(公告)号：KR100295742B1

公开(公告)日：2001-07-03

申请号：KR1019990013597

申请日：1999-04-16

Applicant: 주식회사대성미생물연구소

Inventor： 박승춘 ,  이동규 ,  최양웅 ,  오태광 ,  윤효인

IPC: A61K31/495

Abstract: 본발명은신규동물용복합항생제조성물에관한것으로서, 더욱상세하게는 1:4∼4:1 중량비로혼합된노르플록사신 (norfloxain)과타이로신 (tylosin)의약제학적유효량을포함하는동물용복합항생제조성물에관한것으로서, 가축및 어류의세균성질병치료와예방에유용할뿐만아니라, 고가의신규항균물질을대체할수 있어궁극적으로는축산농가의생산원가를절감시키고약품의축체내잔류도효율적으로최소화시킬수 있는효과가있는동물용복합항생제조성물에관한것이다.

公开(公告)号：KR100206454B1

公开(公告)日：1999-07-01

申请号：KR1019970007088

申请日：1997-03-04

Applicant: 한국과학기술연구원 ,  주식회사대성미생물연구소

Inventor： 오태광 ,  박승춘 ,  변재원 ,  이동규

IPC: C12N1/20

Abstract: 본 발명은 신균주 락토바실러스 속(Lactobacillus sp.) DS-12(KCTC 0298BP)와 이를 이용한 어류용 프로바이오틱스에 관한 것으로서, 더욱 상세하게는 종래보다 개선된 내염성, 내담즙성 및 내산성 등의 생리활성을 갖는 신규한 락토바실러스 속(Lactobacillus sp.) DS-12균주와 이를 어류용 프로바이오틱스(Probiotics)로의 이용에 관한 것이다.