公开(公告)号：KR100371092B1

公开(公告)日：2003-02-05

申请号：KR1019990056274

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/70

Abstract: PURPOSE: A complex antimicrobial composition for animals is provided, which has prevention and treatment effects on bacterial diseases and substitutes the expensive antimicrobial agents for animals. CONSTITUTION: The complex antimicrobial composition for animals comprises fluoroquinoline antimicrobial agents and chitosan oligosaccharides in a ratio of 1:10 to 10:1. Wherein, fluoroquinoline antimicrobial agents are enrofloxacin, ciprofloxacin and Norfloxacin; chitosan oligosaccharides have 2,000,000 to 150,000 molecular weight and 45% or more 1 to 16 saccharides; and the animals are selected from the group consisting of domestic animals comprising chickens, pigs, cows, horses, dogs, ducks and goats, fishes comprising trouts, carps, eels, flatfishes, sea bream and shrimps.

Abstract translation: 目的：提供一种用于动物的复合抗菌组合物，其具有对细菌疾病的预防和治疗效果，并将昂贵的抗微生物剂替代为动物。 组成：用于动物的复合抗微生物组合物包含比例为1:10至10：1的氟喹啉抗微生物剂和壳聚糖寡糖。 其中，氟喹啉类抗菌剂为恩诺沙星，环丙沙星，诺氟沙星; 壳聚糖寡糖具有2,000,000至150,000个分子量和45％或更多的1至16个糖; 并且动物选自由包括鸡，猪，牛，马，狗，鸭和山羊的家畜，包含鳟鱼，鲤鱼，鳗鱼，扁鱼，鲷鱼和虾的鱼组成的组。

公开(公告)号：KR1020010083256A

公开(公告)日：2001-09-01

申请号：KR1019990056275

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/7008

Abstract: PURPOSE: A composite antibiotic composition for animal feeding containing an aminoglycoside-based antibiotic and chitosan-oligosaccharide and exerting synergistic antibacterial activity in mixing is provided, which can be used as an agent for preventing and treating a bacterially caused disease of an animal and an immunostimulating agent. CONSTITUTION: The composite antibiotic composition for animal feeding contains an aminoglycoside-based antibiotic such as gentamicin and chitosan-oligosaccharide in a ratio of 1:5 to 5:1. The chitosan-oligosaccharide has a molecular weight of 2,000,000 to 150,000 and a distribution of 1 to 16 saccharide of 45% or more.

Abstract translation: 目的：提供含有氨基糖苷类抗生素和壳聚糖寡糖的动物饲料复合抗生素组合物，在混合中发挥协同抗菌活性，可用作预防和治疗细菌性动物疾病和免疫刺激的药剂 剂。 构成：用于动物饲养的复合抗生素组合物含有比例为1:5至5:1的氨基糖苷类抗生素如庆大霉素和壳聚糖寡糖。 壳聚糖 - 低聚糖的分子量为200万〜150,000，1〜16糖的分布为45％以上。

公开(公告)号：KR100371090B1

公开(公告)日：2003-02-07

申请号：KR1019990056276

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/70

Abstract: PURPOSE: A complex antibiotic composition for animal containing iron, aminoglycosides antibiotics and chitosan-oligosaccharide is provided, which is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, can be used instead of expensive antibiotics, so that it saves production cost and minimizes residue of medicine. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal comprises the steps of: mixing iron(iron dextran) and aminoglycosides antibiotics such as Gentamicin(or Streptomycin, Kanamycin, Amikacin, Spectinomycin, Neomycin) in the weight ratio of 20-40:1 to get Gentamicin mixed ferrous(GMF); mixing low molecular chitosan-oligosaccharide(OCHT) and the GMF in an adequate ratio to improve administration effect of the iron and aminoglycosides antibiotics, and gaining the complex antibiotic composition for animal.

Abstract translation: 用途：本发明提供一种含铁，氨基糖苷类抗生素和壳寡糖的动物复合抗生素组合物，用于治疗和预防家畜细菌引起的疾病和贫血，可代替昂贵的抗生素使用，从而节省生产成本 并最大限度地减少药物残留。 构成：制备用于动物的复合抗生素组合物的方法包括步骤：将铁（葡聚糖铁）和氨基糖苷类抗生素如庆大霉素（或链霉素，卡那霉素，阿米卡星，壮观霉素，新霉素）以重量比20-40 ：1得到庆大霉素混合亚铁（GMF）; 将低分子壳聚糖 - 寡糖（OCHT）和GMF以适当的比例混合以改善铁和氨基糖苷类抗生素的施用效果，并获得用于动物的复合抗生素组合物。

公开(公告)号：KR1020010058414A

公开(公告)日：2001-07-06

申请号：KR1019990056276

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/70

Abstract: PURPOSE: A complex antibiotic composition for animal containing iron, aminoglycosides antibiotics and chitosan-oligosaccharide is provided, which is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, can be used instead of expensive antibiotics, so that it saves production cost and minimizes residue of medicine. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal comprises the steps of: mixing iron(iron dextran) and aminoglycosides antibiotics such as Gentamicin(or Streptomycin, Kanamycin, Amikacin, Spectinomycin, Neomycin) in the weight ratio of 20-40:1 to get Gentamicin mixed ferrous(GMF); mixing low molecular chitosan-oligosaccharide(OCHT) and the GMF in an adequate ratio to improve administration effect of the iron and aminoglycosides antibiotics, and gaining the complex antibiotic composition for animal.

Abstract translation: 目的：提供含铁，氨基糖苷类抗生素和壳聚糖寡糖的复合抗生素组合物，可用于治疗和预防家畜细菌性疾病和贫血，可代替昂贵的抗生素，从而节省生产成本 并最大限度地减少药物残留。 构成：用于制备动物复合抗生素组合物的方法包括如下步骤：以20-40重量比混合铁（葡聚糖铁）和氨基糖苷类抗生素如庆大霉素（或链霉素，卡那霉素，阿米卡星，壮观霉素，新霉素） ：1得到庆大霉素混合亚铁（GMF）; 以适当的比例混合低分子壳聚糖 - 寡糖（OCHT）和GMF，以改善铁和氨基糖苷类抗生素的施用效果，并获得动物的复合抗生素组合物。

公开(公告)号：KR1020010078497A

公开(公告)日：2001-08-21

申请号：KR1019990056274

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/70

Abstract: PURPOSE: A complex antimicrobial composition for animals is provided, which has prevention and treatment effects on bacterial diseases and substitutes the expensive antimicrobial agents for animals. CONSTITUTION: The complex antimicrobial composition for animals comprises fluoroquinoline antimicrobial agents and chitosan oligosaccharides in a ratio of 1:10 to 10:1. Wherein, fluoroquinoline antimicrobial agents are enrofloxacin, ciprofloxacin and Norfloxacin; chitosan oligosaccharides have 2,000,000 to 150,000 molecular weight and 45% or more 1 to 16 saccharides; and the animals are selected from the group consisting of domestic animals comprising chickens, pigs, cows, horses, dogs, ducks and goats, fishes comprising trouts, carps, eels, flatfishes, sea bream and shrimps.

Abstract translation: 目的：提供用于动物的复合抗微生物组合物，其对细菌性疾病具有预防和治疗作用，并代替昂贵的抗微生物剂用于动物。 构成：用于动物的复合抗微生物组合物包含1:10至10:1比例的氟喹啉抗微生物剂和壳聚糖寡糖。 其中氟喹啉抗菌药是恩氟沙星，环丙沙星和诺氟沙星; 壳聚糖寡糖的分子量为2,000,000至150,000，糖分为45％或更多; 动物选自包括鸡，猪，牛，马，狗，鸭和山羊的家畜，包括鳟鱼，鲤鱼，鳗鱼，鲽鱼，鲷鱼和虾的鱼。

公开(公告)号：KR1020070080216A

公开(公告)日：2007-08-09

申请号：KR1020070009081

申请日：2007-01-29

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  조항원 ,  이원준

IPC: A61K31/7048 ,  A61K31/165 ,  A61K31/04 ,  A61P31/00

CPC classification number: A61K31/7048 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/14 ,  A61K31/165 ,  A61K2300/00

Abstract: An optimum antibiotic complex composition containing florfenicol is provided to offer significantly increased antibacterial effect compared to other antibiotic complex composition of macrolide antibiotic materials by mixing the florfenicol with tyrosine with excellent inhibitory effect of pathogenic microorganism of animal. The antibiotic complex composition for animal is characterized in that it consists of tyrosine and florfenicol in a weight ratio of 1:1.5-6. The antibiotic complex composition is formulated into an injection agent, an oral administration liquid agent, powder or granule. The injection agent or the oral administration liquid agent is prepared by using glycerol formal, N-methyl-2 pyrrolidone, or mixture thereof as a solvent.

Abstract translation: 提供含有氟苯尼考的​​最佳抗生素复合物组合物，通过将氟苯尼考与酪氨酸混合，具有优异的动物病原微生物抑制作用，与​​大环内酯抗生素材料的其他抗生素复合物组合物相比，具有显着增加的抗菌作用。 用于动物的抗生素复合物组合物的特征在于其由酪氨酸和氟苯尼考组成，重量比为1：1.5-6。 将抗生素复合物组合物配制成注射剂，口服给药液剂，粉剂或颗粒剂。 注射剂或口服液剂通过使用甘油形式，N-甲基-2-吡咯烷酮或其混合物作为溶剂来制备。

公开(公告)号：KR100403571B1

公开(公告)日：2003-11-01

申请号：KR1019990056277

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/715

Abstract: PURPOSE: A complex antibiotic composition for animal showing growth-stimulation effect is provided, which contains iron and chitosan-oligosaccharide in the ratio of 1:5-5:1, so that it is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, and can be used instead of expensive antibiotics, therefore it saves production cost and minimizes residue of medicine in animal's body. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal showing growth-stimulation effect is comprised of: mixing iron(iron dextran) and aminoglycosides antibiotics; mixing chitosan-oligosaccharide(OCHT: molecular weight range is 200-99,000, and distribution of 1-16 sugar is more than 55%) and the prepared compound till the mixing ratio of iron and chitosan-oligosaccharide to be in the ratio of 1:5-5:1, and gaining the complex antibiotic composition for animal showing growth-stimulation effect. The complex antibiotic composition can be prepared in the form of an injection or a solution for animal.

Abstract translation: 目的：本发明提供一种复合抗生素组合物，具有生长刺激作用，含有铁与壳聚糖 - 寡糖的比例为1：5-5：1，可用于治疗和预防家畜细菌性疾病 可用于替代昂贵的抗生素，从而节省生产成本，减少动物体内药物残留。 组成：用于制备显示生长刺激作用的动物的复合抗生素组合物的方法包括：混合铁（葡聚糖铁）和氨基糖苷类抗生素; 混合壳聚糖 - 寡糖（OCHT：分子量范围为200-99,000，并且1-16糖的分布大于55％）和所制备的化合物直至铁和壳聚糖 - 寡糖的混合比例为1： 5-5：1，并获得动物复合抗生素组合物，表现出生长刺激作用。 复合抗生素组合物可以以注射剂或动物溶液的形式制备。

公开(公告)号：KR100371091B1

公开(公告)日：2003-02-07

申请号：KR1019990056275

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/7008

Abstract: PURPOSE: A composite antibiotic composition for animal feeding containing an aminoglycoside-based antibiotic and chitosan-oligosaccharide and exerting synergistic antibacterial activity in mixing is provided, which can be used as an agent for preventing and treating a bacterially caused disease of an animal and an immunostimulating agent. CONSTITUTION: The composite antibiotic composition for animal feeding contains an aminoglycoside-based antibiotic such as gentamicin and chitosan-oligosaccharide in a ratio of 1:5 to 5:1. The chitosan-oligosaccharide has a molecular weight of 2,000,000 to 150,000 and a distribution of 1 to 16 saccharide of 45% or more.

Abstract translation: 目的：提供一种用于动物饲养的复合抗生素组合物，其含有氨基糖苷类抗生素和壳聚糖 - 寡糖，并在混合时发挥协同抗菌活性，其可用作预防和治疗动物细菌引起的疾病和免疫刺激 剂。 组成：用于动物饲养的复合抗生素组合物含有比例为1：5至5：1的基于氨基糖苷的抗生素，例如庆大霉素和壳聚糖 - 寡糖。 壳聚糖 - 寡糖的分子量为200万〜150,000，糖的分布为1〜16个糖为45％以上。

公开(公告)号：KR1020020076434A

公开(公告)日：2002-10-11

申请号：KR1020010016262

申请日：2001-03-28

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈

IPC: A61K38/00

Abstract: PURPOSE: An immunostimulating agent containing purified protein of Bordetella pertussis together with a cell wall of a biomass of Staphylococcus aureus Cowan 1 or secretory protein is provided which can reduce the amount of antibiotics used to treat mastitis and hygienical problems such as remaining of antibiotics in milk. CONSTITUTION: The immunostimulating agent contains dead biomass or purified protein of Staphylococcus aureus Cowan 1, purified protein of Bordetella pertussis(ATCC 9797), wherein the immunostimulating agent has efficacy of reducing the number of somatic cells of livestock such as dairy cattle. For example, 10ml immunostimulating agent contains 10mg dead biomass of Staphylococcus aureus Cowan 1, 200 microgram inactivated secretory lethal toxin of Staphylococcus aureus Cowan 1, 200 microgram inactivated secretory lethal toxin of Bordetella pertussis(ATCC 9797) and a suitable amount of an excipient(10% nonfat dry milk).

Abstract translation: 目的：提供含有百日咳博德特氏菌纯化蛋白的免疫刺激剂以及金黄色葡萄球菌Cowan 1或分泌蛋白的生物量的细胞壁，其可以减少用于治疗乳腺炎的抗生素的量和卫生问题，例如在牛奶中残留抗生素 。 构成：免疫刺激剂含有金黄色葡萄球菌Cowan 1的死生物量或纯化蛋白，百日咳博德特氏菌（ATCC 9797）的纯化蛋白，其中免疫刺激剂具有降低家畜如牛奶的体细胞数量的功效。 例如，10ml免疫刺激剂含有10mg金黄色葡萄球菌Cowan的死亡生物质1，200微克灭活的金黄色葡萄球菌Cowan1的200微克灭活的分泌致死毒素，百日咳博德特氏菌（ATCC 9797）200微克灭活的分泌致死毒素和适量的赋形剂（10 ％ 脱脂奶粉）。

公开(公告)号：KR1020010058415A

公开(公告)日：2001-07-06

申请号：KR1019990056277

申请日：1999-12-09

Applicant: 주식회사대성미생물연구소

Inventor： 오경훈 ,  최양웅 ,  이동규 ,  이원준

IPC: A61K31/715

Abstract: PURPOSE: A complex antibiotic composition for animal showing growth-stimulation effect is provided, which contains iron and chitosan-oligosaccharide in the ratio of 1:5-5:1, so that it is useful for treatment and prevention of domestic animal's bacterially caused disease and anemia, and can be used instead of expensive antibiotics, therefore it saves production cost and minimizes residue of medicine in animal's body. CONSTITUTION: A process for the preparation of complex antibiotic composition for animal showing growth-stimulation effect is comprised of: mixing iron(iron dextran) and aminoglycosides antibiotics; mixing chitosan-oligosaccharide(OCHT: molecular weight range is 200-99,000, and distribution of 1-16 sugar is more than 55%) and the prepared compound till the mixing ratio of iron and chitosan-oligosaccharide to be in the ratio of 1:5-5:1, and gaining the complex antibiotic composition for animal showing growth-stimulation effect. The complex antibiotic composition can be prepared in the form of an injection or a solution for animal.

Abstract translation: 目的：提供一种具有生长刺激作用的动物复合抗生素组合物，含有比例为1：5-5：1的铁和壳聚糖寡糖，因此可用于治疗和预防家畜的细菌性疾病 和贫血，可以代替昂贵的抗生素使用，从而节省生产成本，并最大限度地减少动物体内的药物残留。 构成：制备复合抗生素组合物的方法，显示生长刺激作用包括：混合铁（葡聚糖铁）和氨基糖苷类抗生素; 混合壳聚糖 - 低聚糖（OCHT：分子量范围为200-99,000，1-16糖分配超过55％），制备的化合物直至铁和壳聚糖 - 低聚糖的混合比例为1： 5-5：1，获得复合抗生素组合物，显示出生长刺激作用。 复合抗生素组合物可以以注射剂或动物溶液的形式制备。