公开(公告)号：WO2005048945A3

公开(公告)日：2006-03-23

申请号：PCT/US2004038033

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

IPC: C07D471/00 ,  A61K20060101 ,  A61K31/44 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005051317A2

公开(公告)日：2005-06-09

申请号：PCT/US2004/039512

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KREPSKI, Larry, R. ,  DELLARIA, Joseph, F., Jr. ,  DUFFY, Daniel, E. ,  RADMER, Matthew, R. ,  AMOS, David, T.

Inventor： KREPSKI, Larry, R. ,  DELLARIA, Joseph, F., Jr. ,  DUFFY, Daniel, E. ,  RADMER, Matthew, R. ,  AMOS, David, T.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D213/74 ,  C07D255/02 ,  C07D471/14

Abstract: Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位置取代的咪唑环体系，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病 疾病被披露。

公开(公告)号：WO2005048933A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/037854

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D519/00

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有肟取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。