Abstract:
A method, system and computer readable medium for computerized processing of chest images including obtaining a digital first image of a chest (S100); producing a second image which is a mirror image (S300) of the first image; performing image warping on one of the first and second images to produce a warped image (S400) which is registered to the other of the first and second images; and subtracting the warped image from the other image to generate a subtraction image (S600). Another embodiment includes obtaining a digital first image of the chest of a subject; detecting ribcage edges on both sides of the lungs in the first chest image; determining average horizontal locations of the left and right ribcage edges at plural vertical locations; fitting the determined average horizontal locations to a straight line to derive a midline; rotating the chest image so that the midline is vertical; and shifting the rotated image to produce a lateral inclination corrected (S200) second image with the midline centered in the lateral inclination corrected image.
Abstract:
The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.
Abstract:
Method and system for detection of interval change in medical images. Three-dimensional images, such as previous and current section images (10 and 11) in CT scans, are obtained. An anatomic feature, such as lungs, is used to select sections containing lung by a gray-level thresholding technique (13). The section correspondence between the current and previous scans is determined automatically. The initial registration of the corresponding sections in the two scans is achieved by a rotation correction (14) and a cross-correlation (15) technique. A more accurate registration between the corresponding current and previous section images is achieved by local matching (17). A nonlinear warping process (18) which is also based on the cross-correlation technique is applied to the previous image to yield a warped image after the matching. The final subtracted section images (19) were derived by subtracting of the previous section images from the corresponding current section images. Interval changes such as a change in tumor size and a newly developed pleural effusion are enhanced significantly.
Abstract:
The present invention relates generally to amyloidogenesis. More particularly, it concerns the use of amyloidogenic proteins that have been blocked at the N- and/or C-termini and/or side chains to prevent their aggregation into amyloidogenic plaques. Particular aspects of the present invention describe the methods and compositions of inhibition of plaque formation in amyloidoses, for example, Alzheimer's Disease.
Abstract:
A method and apparatus for discrimination of nodules and false positive in digital chest radiographs, using a wavelet snake technique (1802; 1804; 1806; 1808). The wavelet snake is a deformable contour designed to identify the boundary of a relatively round object (1900). The shape of the snake is determined by a set of wavelet coefficient in a certain range of scales. Portions of the boundary of a nodule are first extracted using a multiscale edge representation. The multiscale edge are then fitted (2000; 1814) by a gradient descent procedure which deforms the shape of a wavelet snake by changing its wavelet coefficients. The degree of overlap between the fitted snake and the multiscale edges is calculated and used as a fit quality indicator for discrimination of nodules and false detection (1816; 1818; 1820).
Abstract:
A system (10) and method for monitoring an industrial process and/or industrial data source (10). The system (10) includes a time correlation module (20), a training module (30), a system state estimation module (40) and a pattern recognition module (50). The system (10) generating time varying data sources, processing the data to obtain time correlation of the data (20), determining the range of data, determining learned states of normal operation (30) and using these states to generate expected values to identify a current state of the process closest to a learned, normal state (40); generating a set of modeled data, and processing the modeled data to identify a data pattern and generating an alarm (50) upon detecting a deviation from normalcy.
Abstract:
The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an α4 gene, methods of inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.
Abstract:
The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.