公开(公告)号：EP0538873B1

公开(公告)日：1998-09-09

申请号：EP92118129.3

申请日：1992-10-23

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Ferris, Jonathan R. ,  Brimhall, Kenneth Randy ,  Vanesky, Frank W. ,  Buchanan, D. Scott ,  Warden, Laurence

IPC: A61B5/04

CPC classification number: A61B5/04009

公开(公告)号：EP0705440A1

公开(公告)日：1996-04-10

申请号：EP94921304.0

申请日：1994-06-21

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BUCHANAN, D., Scott ,  WARDEN, Laurence ,  RILEY, Scott, W. ,  JOHNSON, Richard, T. ,  BRIMHALL, K., Randy ,  ESSER, Keith, A.

IPC: A61B5 ,  G01R33

CPC classification number: G01R33/0358 ,  A61B5/0046 ,  A61B5/04005

Abstract: A biomagnetometer includes a magnetic field sensor including a magnetic field pickup coil (210) and a detector (211) of small electrical currents flowing within the pickup coil. A vacuum-tight enclosure (212) surrounds the sensor. The enclosure has a concavely upwardly curved first wall, with the magnetic field pickup coil located adjacent to the first wall. A vented reservoir (220) of liquefied gas is located within the enclosure, and a solid thermal conductor (218) extends from the sensor. There is a vacuum-tight thermal feedthrough by which the solid thermal conductor passes between the interior and the exterior of the enclosure. Electronic circuitry for filtering and amplifying the signals of the detector is also provided. Such a biomagnetometer is placed below the body of a reclining subject, and a second portion of the biomagnetometer can be placed above the body. In one form, the enclosures are shaped to form a cavity that receives the head of the subject therein, to achieve full head coverage of the pickup coils in the biomagnetometer.

Abstract translation: 生物磁力计包括磁场传感器，该磁场传感器包括在拾取线圈内流动的小电流的磁场拾取线圈（210）和检测器（211）。 真空密封的外壳（212）围绕传感器。 外壳具有向上弯曲的凹形第一壁，其中磁场接收线圈位于第一壁附近。 液化气体的通风储器（220）位于外壳内，并且固体热导体（218）从传感器延伸。 有一个真空密封的热馈通，固体热导体可以通过外壳的内部和外部。 还提供了用于过滤和放大检测器信号的电子电路。 这样的生物磁性计被放置在躺卧对象的身体下方，并且生物磁性计的第二部分可以放置在身体上方。 在一种形式中，外壳被成形为形成腔体，该腔体接收其中的对象的头部，以实现生物磁力计中拾取线圈的完全头部覆盖。

公开(公告)号：EP0477434B1

公开(公告)日：1996-02-28

申请号：EP90124050.7

申请日：1990-12-13

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Robinson, Stephen E. ,  Black, William C., Jr.

IPC: A61B5/04 ,  G01R33/035 ,  H01Q3/26

CPC classification number: G06K9/0057 ,  A61B5/04005 ,  A61B5/4064 ,  G01R33/035 ,  H01Q3/26

公开(公告)号：EP0538873A1

公开(公告)日：1993-04-28

申请号：EP92118129.3

申请日：1992-10-23

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Ferris, Jonathan R. ,  Brimhall, Kenneth Randy ,  Vanesky, Frank W. ,  Buchanan, D. Scott ,  Warden, Laurence

IPC: A61B5/04

CPC classification number: A61B5/04009

Abstract: An apparatus for making bioelectromagnetic measurements of the human body includes an apparatus for measuring the bioelectromagnetic reaction (18) of a living body to a tactile stimulation and a tactile stimulator (40) that controllably applies a tactile stimulation to the body without creating a magnetic or electrical field that is detected directly by the apparatus for measuring the bioelectromagnetic reaction. The tactile stimulator includes a pressure chamber (52) closed on one side by a movable body such as a piston (76) or flexible membrane (56), a conduit (60) that transmits pneumatic pressure to the pressure chamber, and apparatus for applying pneumatic pressure (62) to the conduit. The measuring apparatus, such as a biomagnetometer (18), may be located within a shielded room (28), and in this case the pressure chamber (52) and movable body (76,56) are preferably located within the shielded room (28), the apparatus for applying pneumatic pressure (62) is located outside the room, and the conduit (60) passes from the exterior to the interior of the room.

Abstract translation: 用于对人体进行生物电磁测量的装置包括用于测量活体的生物电磁反应（18）到触觉刺激的装置和触觉刺激器（40），该触觉刺激器（40）可触发地对身体施加触觉刺激而不产生磁性或 由用于测量生物电磁反应的装置直接检测的电场。 触觉刺激器包括通过诸如活塞（76）或柔性膜（56）的可移动体在一侧封闭的压力室（52），将气压传递到压力室的导管（60） 气压（62）到导管。 诸如生物计量器（18）的测量装置可以位于屏蔽室（28）内，在这种情况下，压力室（52）和可移动体（76,56）优选位于屏蔽室（28）内 ），用于施加气压（62）的装置位于房间外部，并且导管（60）从外部通过到室内。

公开(公告)号：EP0530596A1

公开(公告)日：1993-03-10

申请号：EP92114180.0

申请日：1992-08-20

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Buchanan, Scott D. ,  Riley, Scott

IPC: A61B5/04 ,  A61B6/08

CPC classification number: A61B5/04005 ,  A61B6/08

Abstract: An apparatus (10) for making magnetic measurements of the human body (12) includes a biomagnetometer (18) having a magnetic field sensing coil (20) that measures magnetic fields arising from a selected portion (14) of a body (12). A position monitor (40) used in conjunction with the biomagnetometer (18) produces no magnetic fields that can interfere with the taking of magnetic field measurements, and can operate simultaneously with the taking of magnetic field measurements. The position monitor (40) includes an optical target (42) mounted on the selected portion (14) of the body (12), the optical target (42) having a variation in light reflectance across the target (42). An input optical guide (50) directs a beam of light at the target (42), an output optical guide (52) collects a reflected beam of light from the target (42), and a limit detector (66) receives the beam of light from the output optical guide (52) and determines whether the intensity of the received light varies outside of predetermined limits.

Abstract translation: 一种用于进行人体（12）的磁测量的装置（10）包括具有测量从身体（12）的选定部分（14）产生的磁场的磁场感测线圈（20）的生物计量器（18）。 与生物计量器（18）一起使用的位置监视器（40）不产生可能干扰磁场测量的磁场，并且可以与采取磁场测量同时进行操作。 位置监视器（40）包括安装在主体（12）的选定部分（14）上的光学目标（42），光学目标（42）具有穿过目标（42）的光反射率变化。 输入光导（50）引导目标（42）上的光束，输出光导（52）收集来自目标（42）的反射光束，并且限位检测器（66）接收 来自输出光导（52）的光，并确定接收光的强度是否在预定极限之外变化。

公开(公告)号：EP0483741A3

公开(公告)日：1992-08-12

申请号：EP91118380.4

申请日：1991-10-29

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Marsden, James R.

IPC: H01L39/24 ,  H01L39/22

CPC classification number: H01L39/025

Abstract: A superconducting quantum interference device (SQUID) (10) is made with a Josephson junction (14) extending between two layers of superconducting material (22, 32). An insulation layer (34) placed between the superconducting layers (22, 32), in the regions displaced from the Josephson junction (14), is made of a polymeric insulation material such as a polyimide. The insulation material may also be used between other metal layers on the same device, such as a planar coil (42) and resistors (36). The insulation material is preferably applied by a spin-on technique.

公开(公告)号：EP0312570A1

公开(公告)日：1989-04-26

申请号：EP88904045.0

申请日：1988-04-08

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： CRUM, Duane, B. ,  WESTLEY, Ronald, C. ,  GREENBLATT, Richard, E. ,  TOUSSAINT, Robert, M. ,  HIRSCHKOFF, Eugene, C.

IPC: G01R33 ,  A61B5

CPC classification number: A61B5/04008 ,  G01R33/00

Abstract: L'appareil (10) permettant d'effectuer des mesures biomagnétiques comprend un biomagnétomètre (18) pour mesurer des champs magnétiques produits par le corps et une mesure de localisation électromagnétique, et il comprend également un système d'enregistrement (20 et 30) pour déterminer automatiquement l'endroit de la partie du corps (12) d'où les signaux magnétiques sont rassemblés. Le système d'enregistrement de localisation électromagnétique permet d'établir un cadre de référence en temps réel du corps par rapport au biomagnétomètre, de sorte que des signaux biomagnétiques peuvent être mis en corrélation directement avec la localisation et la structure de la portion du corps. Le système d'enregistrement de localisation électromagnétique peut fonctionner en continu à des longueurs d'ondes de rayonnement qui n'interfèrent pas avec la prise de données, ou bien de manière intermittente avec la prise de données biomagnétiques pour éviter les interférences avec les valeurs mesurées des données biomagnétiques. Les éléments du système d'enregistrement de localisation électromagnétique ne présentent pratiquement aucun magnétisme résiduel lorsque le système d'enregistrement de localisation n'est pas en fonctionnement, les signaux biomagnétiques étant généralement si petits que même un magnétisme résiduel normal pourrait être enregistré de manière erronée comme un signal biomagnétique.

Abstract translation: 用于执行生物磁测量的设备（10）包括用于测量由身体产生的磁场和电磁位置测量的生物磁力计（18），并且还包括用于以下操作的记录系统（20和30）： 自动确定收集磁信号的身体部位（12）的位置。 电磁定位配准系统为身体提供相对于生物磁力计的实时参照系，从而生物磁信号可以直接与身体部位的位置和结构相关联。 电磁位置记录系统可以在不干扰数据采集的辐射波长下连续操作，或者间歇地采用生物磁数据以避免干扰测量值 生物磁数据。 当位置对准系统不工作时，电磁位置记录系统的元件几乎没有剩余磁性，生物磁信号一般很小，甚至可能错误地记录正常剩余磁性 作为生物磁信号。

公开(公告)号：EP0705440B1

公开(公告)日：2002-02-20

申请号：EP94921304.5

申请日：1994-06-21

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BUCHANAN, D., Scott ,  WARDEN, Laurence ,  RILEY, Scott, W. ,  JOHNSON, Richard, T. ,  BRIMHALL, K., Randy ,  ESSER, Keith, A.

IPC: G01R33/02

CPC classification number: G01R33/0358 ,  A61B5/0046 ,  A61B5/04005

Abstract: A biomagnetometer includes a magnetic field sensor including a magnetic field pickup coil (210) and a detector (211) of small electrical currents flowing within the pickup coil. A vacuum-tight enclosure (212) surrounds the sensor. The enclosure has a concavely upwardly curved first wall, with the magnetic field pickup coil located adjacent to the first wall. A vented reservoir (220) of liquefied gas is located within the enclosure, and a solid thermal conductor (218) extends from the sensor. There is a vacuum-tight thermal feedthrough by which the solid thermal conductor passes between the interior and the exterior of the enclosure. Electronic circuitry for filtering and amplifying the signals of the detector is also provided. Such a biomagnetometer is placed below the body of a reclining subject, and a second portion of the biomagnetometer can be placed above the body. In one form, the enclosures are shaped to form a cavity that receives the head of the subject therein, to achieve full head coverage of the pickup coils in the biomagnetometer.

公开(公告)号：EP0436711B1

公开(公告)日：1996-12-11

申请号：EP90912567.6

申请日：1990-07-30

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： HINSHAW, Waldo, S. ,  PAULSON, Douglas, N. ,  BUCHANAN, David, Scott ,  HIRSCHKOFF, Eugene, C. ,  DiIORIO, MARK, S. ,  BLACK, William, C., Jr.

IPC: G01R33/035 ,  A61B5/05 ,  H01L39/04 ,  A61B5/04

CPC classification number: G01R33/0358 ,  A61B5/04008 ,  Y10S505/846

Abstract: A biomagnetometer (10) has a magnetic pickup coil (12) positioned remotely from a detector (30). The detector (30) is made form a low-temperature superconductor, while in one approach the pickup coil (12) and an electrical connector (56) between the detector (30) and the pickup coil (12) are made of a high-temperature superconductor. In another approach, an inductive coupler (116') connects the detector (30') and the pickup coil (12'). Although the detector (12) is maintained in a dewar (32) at a sufficiently low temperature to reduce electronic noise, the pickup coil (12) and the connection means need only be maintained at a temperature at which they are superconducting. The resulting biomagnetometer (10) permits the pickup coil (12) to be moved and positioned easily, and to be changed readily.

Abstract translation: 生物磁力计（10）具有远离检测器（30）定位的磁性拾波线圈（12）。 检测器（30）由低温超导体制成，而在一种方法中，检测器（30）和拾波线圈（12）之间的拾波线圈（12）和电连接器（56） 温度超导体。 在另一种方法中，电感耦合器（116'）连接检测器（30'）和拾波线圈（12'）。 尽管检测器（12）以足够低的温度保持在杜瓦瓶（32）中以减少电子噪声，但拾取线圈（12）和连接装置仅需保持在它们超导的温度。 所得到的生物磁力计（10）允许拾取线圈（12）容易地移动和定位，并且容易改变。

公开(公告)号：EP0695531A1

公开(公告)日：1996-02-07

申请号：EP95111644.1

申请日：1995-07-25

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： Warden, Laurence

IPC: A61B5/04

CPC classification number: G01R33/035 ,  A61B5/04008

Abstract: A biomagnetometer (20) includes a dewar vessel (34) having a helmet-shaped recess (54) at the lower end of its body (36). The recess (54) is angled at about 45 degrees to the dewar body axis of the dewar vessel. Biomagnetic sensors (26) are positioned within the interior of the dewar vessel body (36) around the periphery of the recess (54). The angled recess (54) permits the biomagnetometer (20) to be used with subjects (24) whose heads (22) are inclined from 0 to 90 degrees to the horizontal by pivoting the dewar vessel (34) over an angle of from -45 degrees to +45 degrees to the vertical, without spilling the cryogenic fluid within the dewar (34) or causing excessive evaporation of the cryogenic fluid.

Abstract translation: 生物仪器（20）包括在其主体（36）的下端具有头盔形凹部（54）的杜瓦瓶（34）。 凹槽（54）与杜瓦瓶的杜瓦体轴线成约45度角。 生物磁传感器（26）围绕凹槽（54）的周边定位在杜瓦瓶体（36）的内部。 成角度的凹槽（54）允许生物计量器（20）与主体（24）一起使用，其主体（22）通过将杜瓦瓶（34）摆动-45°的角度而倾斜于水平方向为0至90度 度至+45度，而不会在杜瓦瓶（34）内溢出低温流体，或导致低温流体过度蒸发。 $$