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    Synthetic diamond articles and their method of manufacture
    34.
    发明公开
    Synthetic diamond articles and their method of manufacture 失效
    Artikel auskünstlichenDiamanten und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0417924A1

    公开(公告)日：1991-03-20

    申请号：EP90309241.9

    申请日：1990-08-23

    Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

    Inventor： Pryor, Roger W.

    IPC: C01B31/06 ,  C30B29/04

    CPC classification number: C23C16/274 ,  C01B32/25 ,  C23C16/01 ,  C30B25/02 ,  C30B29/04 ,  Y10S117/90

    Abstract: Shaped synthetic diamond articles are fabricated by vapour deposition of synthetic diamond on releasable moulds. A process is also provided for forming a shaped synthetic diamond article by coating a mould with an etchable layer and then depositing synthetic diamond on the etchable layer; the etchable layer is thereafter removed in an etchant bath, releasing the diamond article from the mould. The synthetic diamond articles are useful as high-­temperature, corrosion resistant vessels and as wear surfaces.

    Abstract translation: 合成金刚石制品通过将合成金刚石气相沉积在可剥离模具上制造。 还提供了一种通过用可蚀刻层涂覆模具然后将合成金刚石沉积在可蚀刻层上来形成成形合成金刚石制品的方法; 然后在蚀刻剂浴中除去可蚀刻层，将金刚石制品从模具中释放出来。 合成金刚石制品可用作耐高温，耐腐蚀的容器和磨损表面。

    Method and compositions for the treatment of tumors comprising a calcium channel blocker compound of the dihydropyridine class and a platinum coordination compound
    37.
    发明公开
    Method and compositions for the treatment of tumors comprising a calcium channel blocker compound of the dihydropyridine class and a platinum coordination compound 失效
    用于与钙通道阻断剂化合物的含量肿瘤的治疗方法和组合物从类二氢吡啶和铂配位化合物中选择。

    公开(公告)号：EP0221382A1

    公开(公告)日：1987-05-13

    申请号：EP86113897.2

    申请日：1986-10-07

    Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

    Inventor： Honn, Kenneth V. ,  Taylor, John D. ,  Onoda, James M.

    IPC: A61K33/24

    CPC classification number: A61K33/24 ,  A61K31/275 ,  A61K31/44 ,  A61K31/55 ,  A61K2300/00

    Abstract: The invention relates to compositions for the treatment of malignant tumors in a mammal which comprise:

    (a) a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of
    wherein R₁ and R₂ are methyl groups, R₃ and R₄ are alkyl or alkyloxyalkylene groups containing l to 8 carbon atoms and R₅ and R₆ are hydrogen or one or two electron withdrawing substituents; and
    (b) a platinum coordination compound which has antitumor properties in humans wherein the weight ratio of the calcium channel blocker compound to the platinum coordination compound is between l and l000 and l0 to l.

    Furthermore, the invention relates to a method for the treatment of malignant tumors in vitro by administering the afore-mentioned compositions.

    Abstract translation: 本发明涉及一种组合物用于在哺乳动物恶性肿瘤的治疗，其包括：（A）选自下组 worin R1和R2的选择的二氢吡啶类的钙通道阻断剂化合物是甲基，R3和R4是 烷基或烷氧基烷撑基团的含L-至8个碳原子，R5和R6是氢或一个或两个吸电子取代基; 和（b），其具有在人中的抗肿瘤性质的铂配位化合物worin钙通道阻断剂化合物与铂配位化合物的重量比为L，L000和L0至升之间。 进一步地，本发明通过给予前述的组合物涉及用于体外治疗恶性肿瘤的方法。

    COMPOSITE INTRALUMINAL GRAFT
    39.
    发明公开
    COMPOSITE INTRALUMINAL GRAFT 失效
    腔内复合植入体

    公开(公告)号：EP0874602A1

    公开(公告)日：1998-11-04

    申请号：EP96908685.0

    申请日：1996-03-05

    Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY ,  Turi, Zoltan G.

    Inventor： TURI, Zoltan, G.

    IPC: A61F2

    CPC classification number: A61F2/88 ,  A61F2/07 ,  A61F2/852 ,  A61F2/885 ,  A61F2/89 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2220/0008 ,  A61F2230/0013 ,  A61F2250/0063

    Abstract: In accordance with the present invention, a novel composite prosthesis comprises a vein (26) and a cylindrical-shaped member (50). The vein is a vein segment removed from a patient and the cylindrical-shaped member, preferably an expandable stent (50), is glued, sutured, or in some other fashion affixed to the outside surface of the vein (26). The vein segment of the combination is referred to as a vein graft or vein implant to distinguish it from the vascular structure into which it is inserted as a part of the combination. This composite prosthesis is then introduced inside a body passageway, such as diseased arterial segment or inside a saphenous vein graft segment which by-passes an arterial segment. It may be introduced by placement over a balloon catheter (72, 74). When the balloon (74) is inflated, the stent (50) and vein graft (26) expand. The stent prevents recoil and keeps the vein graft tissue in place, while the vein graft forms a new inner lining for the vessel. It is preferred that the vein graft portion of the composite prosthesis be the patient's own vein.

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