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    CHELATING MONOMERS AND POLYMERS
    31.
    发明申请
    CHELATING MONOMERS AND POLYMERS 审中-公开
    吸引单体和聚合物

    公开(公告)号：WO2007120999A3

    公开(公告)日：2008-02-21

    申请号：PCT/US2007063388

    申请日：2007-03-06

    Applicant: BIO RAD LABORATORIES ,  ZHANG HONGMIN ,  BOSCHETTI EGISTO ,  LOMAS LEE O ,  UM PIL-JE

    Inventor： ZHANG HONGMIN ,  BOSCHETTI EGISTO ,  LOMAS LEE O ,  UM PIL-JE

    IPC: A61K39/00

    CPC classification number: C08F220/36 ,  B01D71/28 ,  C02F1/683 ,  C02F2101/20 ,  C08F220/30 ,  C08F222/1006 ,  Y10T436/24

    Abstract: This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.

    Abstract translation: 本发明提供了包含芳基的螯合部分。 包含螯合部分的单体可以聚合成螯合聚合物。 螯合聚合物可用于螯合金属。 金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。 螯合聚合物可以包括在诸如芯片和色谱材料的制品中。

    METHOD FOR QUANTIFYING AN ANALYTE IN A BIOLOGICAL SAMPLE USING MASS SPECTROMETRY
    32.
    发明申请
    METHOD FOR QUANTIFYING AN ANALYTE IN A BIOLOGICAL SAMPLE USING MASS SPECTROMETRY 审中-公开
    使用质谱分析在生物样品中定量分析的方法

    公开(公告)号：WO2007103734A3

    公开(公告)日：2007-12-06

    申请号：PCT/US2007063078

    申请日：2007-03-01

    Applicant: CIPHERGEN BIOSYSTEMS INC ,  LOMAS LEE ,  BOSCHETTI EGISTO

    Inventor： LOMAS LEE ,  BOSCHETTI EGISTO

    IPC: G01N33/50 ,  G01N31/00

    CPC classification number: G01N33/6851 ,  G01N33/96

    Abstract: This invention provides methods for quantifying the amount of analyte in a biological sample, e.g., a clinical sample. The methods comprise creating a calibration series using a complex milieu of proteins comprising a large number of standard proteins and the analyte of interest. The calibration series is used to generate a standard curve for quantification of the analytes in a test biological sample.

    Abstract translation: 本发明提供了用于量化生物样品（例如临床样品）中分析物的量的方法。 所述方法包括使用包含大量标准蛋白质和感兴趣分析物的蛋白质的复杂环境来产生校准序列。 校准系列用于生成测试生物样品中分析物定量的标准曲线。

    METHOD FOR QUANTIFYING AN ANALYTE IN A BIOLOGICAL SAMPLE USING MASS SPECTROMETRY
    33.
    发明申请
    METHOD FOR QUANTIFYING AN ANALYTE IN A BIOLOGICAL SAMPLE USING MASS SPECTROMETRY 审中-公开
    用质谱法定量生物样品中分析物的方法

    公开(公告)号：WO2007103734A2

    公开(公告)日：2007-09-13

    申请号：PCT/US2007/063078

    申请日：2007-03-01

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  LOMAS, Lee ,  BOSCHETTI, Egisto

    Inventor： LOMAS, Lee ,  BOSCHETTI, Egisto

    IPC: G01N33/50

    CPC classification number: G01N33/6851 ,  G01N33/96

    Abstract: This invention provides methods for quantifying the amount of analyte in a biological sample, e.g., a clinical sample. The methods comprise creating a calibration series using a complex milieu of proteins comprising a large number of standard proteins and the analyte of interest. The calibration series is used to generate a standard curve for quantification of the analytes in a test biological sample.

    Abstract translation: 本发明提供了用于量化生物样品（例如临床样品）中的分析物的量的方法。 该方法包括使用包含大量标准蛋白质和感兴趣分析物的复杂环境的蛋白质创建校准系列。 校准系列用于生成标准曲线，用于定量测试生物样品中的分析物。

    FLUIDICS DEVICE
    34.
    发明申请
    FLUIDICS DEVICE 审中-公开
    流体装置

    公开(公告)号：WO2006127056A2

    公开(公告)日：2006-11-30

    申请号：PCT/US2006/001687

    申请日：2006-01-19

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  LOMAS, Lee ,  DING, Jian ,  BOSCHETTI, Egisto

    Inventor： LOMAS, Lee ,  DING, Jian ,  BOSCHETTI, Egisto

    IPC: B01D71/06

    CPC classification number: G01N30/461 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/563 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/087 ,  B01L2400/0487 ,  C07K1/34 ,  G01N27/44704 ,  G01N27/44795 ,  G01N30/466 ,  G01N30/468 ,  Y10T137/2224 ,  Y10T137/794 ,  Y10T137/86187 ,  Y10T436/255

    Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

    Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。

    MULTI-COMPARTMENT FILTER AND METHOD OF FILTERING USING SAME
    36.
    发明申请
    MULTI-COMPARTMENT FILTER AND METHOD OF FILTERING USING SAME 审中-公开
    多层过滤器和使用该过滤器的过滤方法

    公开(公告)号：WO2005089910A1

    公开(公告)日：2005-09-29

    申请号：PCT/US2005/007054

    申请日：2005-03-08

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  BOSCHETTI, Egisto ,  LOMAS, Lee, O. ,  GIROT, Pierre

    Inventor： BOSCHETTI, Egisto ,  LOMAS, Lee, O. ,  GIROT, Pierre

    IPC: B01D57/02

    CPC classification number: G01N27/44704 ,  B01D57/02 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J2220/54 ,  C07K1/24 ,  C07K1/34 ,  G01N27/44795

    Abstract: Each embodiment includes a central sample reservoir (110) and a plurality of satellite reservoirs (120 A-H). In a first embodiment, a first electrode (140) in electrical contact with the central reservoir is charged and second electrodes (150 A-H) in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.

    Abstract translation: 每个实施例包括中央样品储存器（110）和多个卫星储存器（120A-H）。 在第一实施例中，与中央储存器电接触的第一电极（140）被充电，并且与卫星储存器电接触的第二电极（150AH）被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器 。 在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。 在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。 样品中的一些分子被pI过滤到第一和第二卫星储层中。 然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。 样品中的一些分子被pI过滤到第三和第四卫星储层中。

    PHOTOCROSSLINKED HYDROGEL SURFACE COATINGS
    39.
    发明申请
    PHOTOCROSSLINKED HYDROGEL SURFACE COATINGS 审中-公开
    光致交联水凝胶表面涂层

    公开(公告)号：WO2004076511A2

    公开(公告)日：2004-09-10

    申请号：PCT/US2004/004847

    申请日：2004-02-20

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  HUANG, Wenxi ,  AGROSKIN, Yury ,  BOSCHETTI, Egisto

    Inventor： HUANG, Wenxi ,  AGROSKIN, Yury ,  BOSCHETTI, Egisto

    IPC: C08G

    CPC classification number: H01J49/0418 ,  A61L27/52

    Abstract: A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. A hydrogel-coated substrate thus obtained is particularly useful as a probe for mass spectroscopic analysis, including SELDI analysis. Hydrogel particles also can be used for SELDI analysis.

    Abstract translation: 当层原位形成时，使用分别包含具有可光交联官能团的单体亚单元的聚合物或共聚物前体，将水凝胶层有利地施加到基底上 和具有用于结合生物分子分析物（例如蛋白质）的化学选择性官能团的单体亚基。 如此获得的水凝胶涂覆的基材特别用作质谱分析的探针，包括SELDI分析。 水凝胶颗粒也可用于SELDI分析。

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