公开(公告)号：WO2011149972A2

公开(公告)日：2011-12-01

申请号：PCT/US2011/037785

申请日：2011-05-24

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  YOO, Hongki ,  SHISHKOV, Milen ,  GARDECKI, Joseph ,  SHUBOCHKIN, Roman ,  MORSE, Theodore ,  JAFFER, Amin, Farouc

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  YOO, Hongki ,  SHISHKOV, Milen ,  GARDECKI, Joseph ,  SHUBOCHKIN, Roman ,  MORSE, Theodore ,  JAFFER, Amin, Farouc

IPC: A61B5/00 ,  G01N21/64 ,  G01B9/02

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract translation: 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：WO2011109828A2

公开(公告)日：2011-09-09

申请号：PCT/US2011027437

申请日：2011-03-07

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

Abstract translation: 可以提供可以生成与样品的至少一部分相关联的数据的系统和方法的示例性实施例。 例如，可以通过至少一个光学布置将至少一个第一辐射转发到该部分。 可以从基于第一辐射的部分接收至少一个第二辐射。 基于光学布置和第一辐射和/或第二辐射之间的相互作用，光学装置可以具有第一传递函数。 此外，可以通过这种光学装置（或通过另一种光学装置）将至少一个第三辐射转发到该部分，并且从基于第三辐射的部分接收至少一个第四辐射。 基于光学布置（或另一个光学布置）与第三辐射和/或第四辐射之间的相互作用，光学布置（或另一个光学布置）可以具有第二传递函数。 第一传递函数可以至少部分地不同于第二传递函数。 可以基于第二和第四辐射来生成数据。

公开(公告)号：WO2011044301A2

公开(公告)日：2011-04-14

申请号：PCT/US2010/051715

申请日：2010-10-06

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  KANG, Dongkyun ,  YOO, Hongki

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  KANG, Dongkyun ,  YOO, Hongki

IPC: A61B5/055 ,  A61B5/00

CPC classification number: A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

Abstract: An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

Abstract translation: 可以提供根据本公开的装置和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少三分之一布置，可以基于第二电磁辐射将部分中的至少一种特定的嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或营养细胞与其他细胞区分开。

公开(公告)号：WO2011008822A3

公开(公告)日：2011-01-20

申请号：PCT/US2010/041923

申请日：2010-07-14

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SUTER, Melissa ,  BOUMA, Brett, E. ,  JAFFER, Farouc, A.

Inventor： TEARNEY, Guillermo, J. ,  SUTER, Melissa ,  BOUMA, Brett, E. ,  JAFFER, Farouc, A.

IPC: A61B5/021 ,  A61B5/02 ,  A61B5/027

Abstract: Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

公开(公告)号：WO2010090837A2

公开(公告)日：2010-08-12

申请号：PCT/US2010/021514

申请日：2010-01-20

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  KANG, Dongkyun ,  SUTER, Melissa, J.

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  KANG, Dongkyun ,  SUTER, Melissa, J.

IPC: A61B1/04

CPC classification number: A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

Abstract: Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

Abstract translation: 可以提供用于确定生物组织上或生物组织中的位置的装置，方法和系统的示例性实施例。 例如，使用这样的示例性实施例，可以控制光学成像探针的焦点。 在另一个示例性实施例中，可以与光学成像探头一起实现标记设备， 根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。 此外，可以基于该信息，使用至少一个电磁辐射在该部分的至少位置上或至少位置处引起可见的变化。

公开(公告)号：WO2008016927A3

公开(公告)日：2008-02-07

申请号：PCT/US2007/074873

申请日：2007-07-31

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  MOTZ, Jason, T.

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  MOTZ, Jason, T.

IPC: G01J3/44 ,  G01N21/65

Abstract: An optical fibre arrangement for Raman Spectroscopy wherein at least one portion of the fiber arrangement may be composed of or can include therein sapphire, diamond, clear graphite, Chalcogenide, borosilicate, zirconium fluoride, silver halide, a liquid core light guide, a gas core light guide, a hollow core waveguide, and/or a solid core photonic crystal fiber. A receiving arrangement may be configured to receive the electromagnetic radiation that is filtered and received from the sample. At least one first characteristic of at least one portion of the optical fiber can be controlled so as to modify at least one second characteristic of at least one s.econd electromagnetic radiation generated within the optical fiber. The second electromagnetic radiation can be associated with the first electromagnetic radiation.

公开(公告)号：WO2007149602A3

公开(公告)日：2007-12-27

申请号：PCT/US2007/061479

申请日：2007-02-01

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

Inventor： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

IPC: A61B18/20 ,  A61N5/06

Abstract: According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/lOth of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

公开(公告)号：WO2007149602A2

公开(公告)日：2007-12-27

申请号：PCT/US2007061479

申请日：2007-02-01

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

CPC classification number: A61B18/24 ,  A61B5/0066 ,  A61B2017/00066 ,  A61B2017/22051 ,  A61B2018/2272

Abstract: According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/lOth of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

Abstract translation: 根据本发明的一个示例性实施例，可以提供用于将激光辐射施加到生物结构的至少一部分的方法和系统。 例如，可以向该部分提供激光辐射束，而光束的横截面积至多为至少一部分的整个面积的约1/10。 可以基于预定图案将光束施加到部分（a），（b）同时调制激光辐射的波长，和/或（c）同时监视激光辐射的施加深度。

公开(公告)号：WO2007149601A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/061474

申请日：2007-02-01

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

Inventor： TEARNEY, Guillermo, J. ,  SHISHKOV, Milen ,  BOUMA, Brett, E. ,  VAKOC, Benjamin, J.

CPC classification number: A61B18/24 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/2211 ,  A61B2018/2272 ,  G02B23/2423

Abstract: An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.

Abstract translation: 可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。 该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。 第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。 该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。 该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转 的电磁辐射。

公开(公告)号：WO2007084959A1

公开(公告)日：2007-07-26

申请号：PCT/US2007/060717

申请日：2007-01-18

Applicant: THE GENERAL HOSPITAL CORPORATION ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  OZCAN, Aydogan

Inventor： TEARNEY, Guillermo, J. ,  BOUMA, Brett, E. ,  OZCAN, Aydogan

IPC: G02B27/46 ,  G02B27/08 ,  G02B21/36

CPC classification number: G02B27/08 ,  G01J3/36 ,  G02B17/006 ,  G02B21/00 ,  G02B21/367 ,  G02B27/46

Abstract: Exemplary apparatus and method for obtaining information associated with at least one image of at least one portion of a sample can be provided. For example, at least one first electro¬ magnetic radiation can be provided from the at least one portion (e.g., using a first electro-magnetic radiation guiding arrangement which is configured to provide). A plurality of spatial frequency bands of the image associated with the first electro-magnetic radiation can be generated. Further, at least one second electro-magnetic radiation which is associated with the spatial frequency bands of the image can be received (e.g., using a second arrangement), and the image can be reconstructed based on the spatial frequency bands.

Abstract translation: 可以提供用于获得与样品的至少一部分的至少一个图像相关联的信息的示例性装置和方法。 例如，可以从至少一个部分（例如，使用配置为提供的第一电磁辐射引导装置）提供至少一个第一电磁辐射。 可以产生与第一电磁辐射相关联的图像的多个空间频带。 此外，可以接收与图像的空间频带相关联的至少一个第二电磁辐射（例如，使用第二布置），并且可以基于空间频带重建图像。