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公开(公告)号：US20170189469A1
公开(公告)日：2017-07-06
申请号：US15424758
申请日：2017-02-03
Applicant: CoDa Therapeutics, Inc.
Inventor： David BECKER , Colin GREEN , Bradford DUFT
CPC classification number: A61K38/08 , A61K9/0051 , A61K38/10 , A61K38/385 , A61L17/005 , A61L27/54 , A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/608
Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.
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公开(公告)号：US20160244759A1
公开(公告)日：2016-08-25
申请号：US15057958
申请日：2016-03-01
Applicant: CoDa Therapeutics, Inc.
Inventor： Bradford J. DUFT , David L. BECKER
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K31/7105 , A61K31/713 , A61K45/06 , C12N2310/111 , C12N2320/32 , A61K2300/00
Abstract: Anti-cadherin and anti-ZO-1 agents and compositions, and kits containing them for use in the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.
Abstract translation: 抗钙粘蛋白和抗ZO-1剂和组合物，以及含有它们的用于促进和/或改善伤口愈合和/或组织修复以及抗瘢痕形成，抗炎，抗纤维化和抗 粘附指示。
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公开(公告)号：US20140275218A1
公开(公告)日：2014-09-18
申请号：US14214922
申请日：2014-03-15
Applicant: CoDa Therapeutics, Inc.
Inventor： Anthony PHILLIPS , David EISENBUD , Scott BANNAN , David POOL , Grove MATSUOKA , Tracey SUNDERLAND , Bradford DUFT
CPC classification number: A61K31/7088 , A61B5/0064 , A61B5/0077 , A61B5/1072 , A61B5/1079 , A61B5/1109 , A61B5/445 , A61B5/4839 , A61B5/4848 , A61B5/7275 , A61B2503/40 , A61K9/0014 , A61K9/06 , A61K9/70 , A61K31/7105 , A61K47/00 , A61K47/10 , A61K47/38 , A61K48/00 , C07K14/47 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12N2320/35
Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.
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公开(公告)号：US10465188B2
公开(公告)日：2019-11-05
申请号：US14833041
申请日：2015-08-21
Applicant: AUCKLAND UNISERVICES LIMITED , CODA THERAPEUTICS, INC.
Inventor： Colin Richard Green , Yeri Kim , Anthony Phillips , Bradford James Duft
IPC: C07H21/04 , C12N15/113 , A61K38/08 , A61K38/39 , A61K9/00 , A61K31/352 , A61K31/713 , A61K38/10 , A61K45/06 , A61K31/167 , A61K31/195 , A61K31/382 , A61K31/498 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/575 , A61P27/02
Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
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公开(公告)号：US10174316B2
公开(公告)日：2019-01-08
申请号：US14467978
申请日：2014-08-25
Applicant: CoDa Therapeutics, Inc.
Inventor： Wilda Laux , Colin Richard Green
IPC: C07H21/02 , C07H21/04 , A61K31/70 , C12N15/113 , C12N15/11 , A61K31/7105 , A61K31/711 , C12N5/00
Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.
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Patent Agency Ranking
公开(公告)号：US09932592B2
公开(公告)日：2018-04-03
申请号：US14951424
申请日：2015-11-24
Applicant: CoDa Therapeutics, Inc.
Inventor： David Lawrence Becker , Colin Richard Green
IPC: C07H21/02 , C07H21/04 , A61K31/70 , C12N15/113 , A61K31/711 , A61K9/00 , A61K9/06 , A61K47/34 , C12N5/00
CPC classification number: C12N15/1138 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K31/711 , A61K47/34 , C12N2310/11 , C12N2320/32
Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.
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公开(公告)号：US20170240905A1
公开(公告)日：2017-08-24
申请号：US15583898
申请日：2017-05-01
Applicant: CoDa Therapeutics, Inc.
Inventor： David L. BECKER , Colin Richard GREEN , Bradford J. DUFT
IPC: C12N15/113
CPC classification number: C12N15/1138 , A61K31/7105 , C12N2310/11 , C12N2310/14 , C12N2320/35
Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
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公开(公告)号：US09637745B2
公开(公告)日：2017-05-02
申请号：US14709382
申请日：2015-05-11
Applicant: CoDa Therapeutics, Inc.
Inventor： David Lawrence Becker , Colin Richard Green , Bradford James Duft
IPC: A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/7105 , C12Q1/68
CPC classification number: C12N15/1138 , A61K31/7105 , C12N2310/11 , C12N2310/14 , C12N2320/35
Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
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公开(公告)号：US20160177298A1
公开(公告)日：2016-06-23
申请号：US14833041
申请日：2015-08-21
Applicant: AUCKLAND UNISERVICES LIMITED , CODA THERAPEUTICS, INC.
Inventor： Colin Richard GREEN , Yeri KIM , Anthony PHILLIPS , Bradford James DUFT
IPC: C12N15/113 , A61K38/10 , A61K31/352 , A61K38/08 , A61K31/713 , A61K45/06
CPC classification number: C12N15/113 , A61K9/0048 , A61K31/167 , A61K31/195 , A61K31/352 , A61K31/382 , A61K31/498 , A61K31/5377 , A61K31/557 , A61K31/5575 , A61K31/575 , A61K31/713 , A61K38/08 , A61K38/10 , A61K38/39 , A61K45/06 , A61P27/02 , C12N15/1138 , C12N2310/11 , C12N2310/3231 , A61K2300/00
Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
Abstract translation: 本发明涉及包含连接蛋白调节剂，潘尼辛调节剂，间隙连接调节剂，半通道调节剂和潘尼辛通道调节剂的组合物和制品，以及它们单独或组合用于治疗眼部和其它疾病的用途。
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公开(公告)号：US20150315598A1
公开(公告)日：2015-11-05
申请号：US14709382
申请日：2015-05-11
Applicant: CoDa Therapeutics, Inc.
Inventor： David Lawrence BECKER , Colin Richard GREEN , Bradford James DUFT
IPC: C12N15/113
CPC classification number: C12N15/1138 , A61K31/7105 , C12N2310/11 , C12N2310/14 , C12N2320/35
Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.
Abstract translation: 用于治疗不按预期速率愈合的伤口的连接蛋白调节剂，包括延迟愈合伤口，不完全愈合的伤口和慢性伤口，以及相关方法，组合物和制品。
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