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    AN ASPIRATE-DISPENSE APPARATUS AND ASSOCIATED METHODS
    32.
    发明申请
    AN ASPIRATE-DISPENSE APPARATUS AND ASSOCIATED METHODS 审中-公开

    公开(公告)号：WO2021023968A1

    公开(公告)日：2021-02-11

    申请号：PCT/GB2020/051769

    申请日：2020-07-23

    Applicant: DOUGLAS SCIENTIFIC, LLC ,  LGC LIMITED

    Inventor： WESTAD, Nathan Luther ,  HAUG, Andrew Richard

    IPC: G01N35/10 ,  G01N35/00 ,  B01L3/02

    Abstract: A controller configured to control one or more of aspiration and dispensing of a primary fluid by an aspirate-dispense apparatus, the aspirate-dispense apparatus comprising a secondary fluid in working communication with the primary fluid, wherein the controller is configured to: receive measurement signalling for a monitored flow parameter of the secondary fluid; determine, using calibration data, a volume of aspirated or dispensed primary fluid based on the received measurement signalling, the calibration data defining a relationship between the volume of aspirated or dispensed primary fluid and the monitored flow parameter of the secondary fluid; and control the flow of primary or secondary fluid based on the determined volume to aspirate or dispense a specific volume of primary fluid.

    SAMPLE PROCESSING DEVICES, AND METHODS OF USE THEREOF
    33.
    发明申请
    SAMPLE PROCESSING DEVICES, AND METHODS OF USE THEREOF 审中-公开
    样品加工装置及其使用方法

    公开(公告)号：WO2016197123A2

    公开(公告)日：2016-12-08

    申请号：PCT/US2016/036050

    申请日：2016-06-06

    Applicant: DOUGLAS SCIENTIFIC, LLC

    Inventor： HJELSETH, Robert ,  HODGSON, Cory ,  BRISTOW, Andrew ,  BAUMGARTNER, Mark ,  SELLNOW, David ,  KEPPEL, Cassie ,  STECKELBERG, John ,  NEWMAN, Paul

    IPC: B01L3/00 ,  G01N1/28 ,  C12M3/00

    CPC classification number: B01L3/50 ,  B01L3/502 ,  B01L3/508 ,  B01L3/5635 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0457 ,  C12M45/06

    Abstract: Embodiments of the invention provide a filter kit including filters for processing a biological sample. Some embodiments include a filter cap in a tube kit with a first tube containing a buffer solution and a second tube containing a lyophilized master mix. Some embodiments include a method of processing a sample using the kit including mixing a biological sample in a first tube with the buffer solution, positioning the filter cap in the first tube, positioning a second tube on the filter cap, flipping the first tube, the filter cap, and the second cap to filter the biological sample and buffer solution mixture with the filter cap as it flows from the first tube to the second tube. Some embodiments include structure enabling transfer of materials through inline flow between the tubes. Some further embodiments include integrated structure for sample pulverization with integrated buffer and lyophilized master mix.

    Abstract translation: 本发明的实施方案提供了一种过滤器套件，其包括用于处理生物样品的过滤器。 一些实施例包括管套件中的过滤器盖，其中包含缓冲溶液的第一管和含有冻干的主混合物的第二管。 一些实施方案包括使用试剂盒处理样品的方法，包括将第一管中的生物样品与缓冲溶液混合，将过滤帽定位在第一管中，将第二管定位在过滤帽上，翻转第一管， 过滤器盖和第二帽，以便当过滤帽从第一管流向第二管时，过滤生物样品和缓冲溶液混合物与过滤嘴盖。 一些实施例包括能够通过管之间的直列流传输材料的结构。 一些另外的实施方案包括用于具有集成缓冲液和冻干的主混合物的样品粉碎的整体结构。

    SILICA-BASED BIOLOGICAL MATERIAL ISOLATION
    34.
    发明申请
    SILICA-BASED BIOLOGICAL MATERIAL ISOLATION 审中-公开
    二氧化硅基生物材料隔离

    公开(公告)号：WO2014116813A1

    公开(公告)日：2014-07-31

    申请号：PCT/US2014/012726

    申请日：2014-01-23

    Applicant: DOUGLAS SCIENTIFIC

    Inventor： MISCHE, Hans

    IPC: C07H21/00 ,  C07H1/06 ,  C07H1/08

    CPC classification number: C12Q1/6806 ,  B01L3/0255 ,  C07H1/06 ,  C07H1/08 ,  C07H21/00 ,  G01N1/405

    Abstract: An apparatus for isolating nucleic acids includes an elongated body. The elongated body includes a silica surface positioned and configured to bind the nucleic acids when the elongated body is dipped into a biological material sample.

    Abstract translation: 用于分离核酸的装置包括细长体。 细长体包括二氧化硅表面，其被定位并构造成当细长体浸入生物材料样品中时结合核酸。

    PIPETTE WASH
    37.
    发明申请
    PIPETTE WASH 审中-公开

    公开(公告)号：WO2014179584A1

    公开(公告)日：2014-11-06

    申请号：PCT/US2014/036390

    申请日：2014-05-01

    Applicant: DOUGLAS SCIENTIFIC

    Inventor： SMITH, Chad Steven ,  HENDRICKX, Jacob ,  MISCHE, Hans A.

    IPC: B01L99/00 ,  B08B9/02 ,  B01L3/02

    CPC classification number: B01L99/00 ,  B01L3/0275 ,  B01L2400/049 ,  B08B9/0323 ,  G01N35/1004

    Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), running a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

    Abstract translation: 用残留的生物材料清洗移液管尖端（94）的阵列的方法包括将移液管尖端（94）的阵列降低到包括齐平端口（22）的阵列的洗脸盆（20）中。 产生真空，使得移液管吸头阵列（94）中的剩余生物材料通过冲洗口（22）阵列排空。 执行洗涤循环，其包括从洗脸盆（20）提起移液管尖端（94）的阵列，用主洗涤液体填充洗手盆（20），将移液管尖端（94）排列成洗涤盆 （20），运行移液管吸头清洁循环，并产生真空，使得移液管吸头阵列（94）和洗手盆（20）中的主要洗涤液体通过冲洗口（22）阵列排空。

    MICROPLATE AND METHODS FOR MAKING THE SAME
    39.
    发明申请
    MICROPLATE AND METHODS FOR MAKING THE SAME 审中-公开

    公开(公告)号：US20190143320A1

    公开(公告)日：2019-05-16

    申请号：US16242884

    申请日：2019-01-08

    Applicant: DOUGLAS SCIENTIFIC, LLC

    Inventor： Bruce Malcolm Peterson

    IPC: B01L3/00 ,  B29C65/00 ,  B29C51/00 ,  B29C65/18

    Abstract: A microplate (10) includes a carrier (12) having a plate (20) and an annular perimeter wall (30) to define a recess (34). An array of holes (26) extends through the plate (20). A tape piece (16), die cut from a flexible tape (60) includes an array of wells (54) each extending through and having an opening (56) extending into the well (54). The array of wells (54) has a number and locations corresponding to the array of holes (26). The openings (56) have sizes corresponding to the holes (26). An upper surface (50) of the tape piece (16) is abutted with and bonded to the bottom face (24) of the plate (20) with the openings (56) corresponding to the array of holes (26). The slideable receipt of an annular outer periphery (58) of the tape piece (16) insures that the array of wells (54) are aligned to correspond to the array of holes (26) as die cutting of tape piece (16) insures that the array of wells (54) are at consistent positions relative to the annular outer periphery (58).

    PIPETTE WASH
    40.
    发明申请
    PIPETTE WASH 审中-公开

    公开(公告)号：US20160101423A1

    公开(公告)日：2016-04-14

    申请号：US14888005

    申请日：2014-05-01

    Applicant: DOUGLAS SCIENTIFIC, LLC

    Inventor： Chad Steven Smith ,  Jacob Hendrickx ,  Hans A. Mische

    IPC: B01L99/00 ,  B08B9/032 ,  B01L3/02

    CPC classification number: B01L99/00 ,  B01L3/0275 ,  B01L13/02 ,  B01L2400/049 ,  B08B9/0323 ,  G01N35/1004

    Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), miming a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

    Abstract translation: 用残留的生物材料清洗移液管尖端（94）的阵列的方法包括将移液管尖端（94）的阵列降低到包括齐平端口（22）的阵列的洗脸盆（20）中。 产生真空，使得移液管吸头（94）阵列中的残余生物材料通过冲洗口（22）阵列排空。 执行洗涤循环，其包括从洗脸盆（20）提起移液管尖端（94）的阵列，用主洗涤液体填充洗脸盆（20），将移液管尖端（94）排列成洗涤盆 （20），模拟移液器吸头清洁循环，并产生真空，使得移液管吸头阵列（94）和洗手盆（20）中的主要洗涤液体通过冲洗口（22）阵列排出。

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