公开(公告)号：EP2991767B1

公开(公告)日：2018-12-12

申请号：EP14791217.4

申请日：2014-05-01

Applicant: Douglas Scientific, LLC

Inventor： SMITH, Chad Steven ,  HENDRICKX, Jacob ,  MISCHE, Hans A.

IPC: B01L99/00 ,  B08B9/02 ,  B01L3/02 ,  B08B9/032 ,  G01N35/10

CPC classification number: B01L99/00 ,  B01L3/0275 ,  B01L2400/049 ,  B08B9/0323 ,  G01N35/1004

Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), miming a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

公开(公告)号：EP2991767A1

公开(公告)日：2016-03-09

申请号：EP14791217.4

申请日：2014-05-01

Applicant: Douglas Scientific, LLC

Inventor： SMITH, Chad Steven ,  HENDRICKX, Jacob ,  MISCHE, Hans A.

IPC: B01L99/00 ,  B08B9/02 ,  B01L3/02

CPC classification number: B01L99/00 ,  B01L3/0275 ,  B01L2400/049 ,  B08B9/0323 ,  G01N35/1004

Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), running a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

Abstract translation: 用剩余生物材料清洗移液管尖端（94）阵列的方法包括将移液管尖端（94）阵列降低到包括一排冲洗端口（22）的清洗盆（20）中。 产生真空，使得移液管尖端（94）阵列中的残余生物材料通过冲洗端口阵列（22）被抽空。 执行洗涤循环，该循环包括从洗手盆（20）升起移液管吸头（94）阵列，用主洗涤液填充洗手盆（20），将移液管吸头（94）阵列降低到洗手盆 （20），运行移液管尖端清洁循环，并产生真空，使得移液管尖端（94）和洗手盆（20）的阵列中的主要清洗流体通过冲洗端口阵列（22）被抽空。

公开(公告)号：EP3709026A1

公开(公告)日：2020-09-16

申请号：EP20173320.1

申请日：2015-07-28

Applicant: Douglas Scientific, LLC

Inventor： COOK, Darren Lynn ,  JOHNSON, Eric Guy ,  WESTAD, Nathan Luther ,  HAUG, Andrew Richard ,  KONYNENBELT, James Henry ,  MAASJO, Grant Edward ,  PATTERSON, Jared Whittier ,  URKE, Brent Conrad ,  ZITZMANN, Ryan John ,  SMITH, Chad Steven

IPC: G01N35/02 ,  B01L3/00 ,  G01N35/10 ,  G01N35/00

Abstract: A dispensing assembly comprising:
a gantry with an x-axis track and a y-axis track, the y-axis track of the gantry configured to move along the x-axis track of the gantry;
a dispensing head attached to the y-axis track of the gantry below the y-axis track of the gantry, the dispensing head comprising:
a contact dispensing unit; and
a non-contact dispensing unit with a jet tip for dispensing a liquid;
a dispensing enclosure attached to the y-axis track of the gantry on top of the y-axis track of the gantry, the dispensing enclosure having a pressure reservoir; and
a tube connecting the jet tip of the non-contact dispensing unit to the pressure reservoir of the dispensing enclosure;

wherein the contact dispensing unit is attached to the y-axis track of the gantry with a first z-axis track; and
wherein the non-contact dispensing unit is attached to the contact dispensing unit with a second z-axis track.

公开(公告)号：EP3175247B1

公开(公告)日：2020-08-19

申请号：EP15826849.0

申请日：2015-07-28

Applicant: Douglas Scientific, LLC

Inventor： COOK, Darren Lynn ,  JOHNSON, Eric Guy ,  WESTAD, Nathan Luther ,  HAUG, Andrew Richard ,  KONYNENBELT, James Henry ,  MAASJO, Grant, Edward ,  PATTERSON, Jared, Whittier ,  URKE, Brent Conrad ,  ZITZMANN, Ryan John ,  SMITH, Chad Steven

IPC: G01N35/02 ,  B01L3/00

公开(公告)号：EP3175247A1

公开(公告)日：2017-06-07

申请号：EP15826849.0

申请日：2015-07-28

Applicant: Douglas Scientific, LLC

Inventor： COOK, Darren Lynn ,  JOHNSON, Eric Guy ,  WESTAD, Nathan Luther ,  HAUG, Andrew Richard ,  KONYNENBELT, James Henry ,  MAASJO, Grant, Edward ,  PATTERSON, Jared, Whittier ,  URKE, Brent Conrad ,  ZITZMANN, Ryan John ,  SMITH, Chad Steven

IPC: G01N35/02

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract translation: 用于处理生物样品的仪器包括底盘。 连接到底盘的是磁带路径，带有矩阵阵列的磁带可以通过仪器自动前进，用于将生物样品和试剂分配到带的孔的基质中的分配组件以形成生物样品， 试剂混合物，用于密封带中的生物样品和试剂混合物的密封组件，以及扩增和检测组件，用于检测来自带中的孔中的生物样品和试剂混合物的信号。

公开(公告)号：WO2014179584A1

公开(公告)日：2014-11-06

申请号：PCT/US2014/036390

申请日：2014-05-01

Applicant: DOUGLAS SCIENTIFIC

Inventor： SMITH, Chad Steven ,  HENDRICKX, Jacob ,  MISCHE, Hans A.

IPC: B01L99/00 ,  B08B9/02 ,  B01L3/02

CPC classification number: B01L99/00 ,  B01L3/0275 ,  B01L2400/049 ,  B08B9/0323 ,  G01N35/1004

Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), running a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

Abstract translation: 用残留的生物材料清洗移液管尖端（94）的阵列的方法包括将移液管尖端（94）的阵列降低到包括齐平端口（22）的阵列的洗脸盆（20）中。 产生真空，使得移液管吸头阵列（94）中的剩余生物材料通过冲洗口（22）阵列排空。 执行洗涤循环，其包括从洗脸盆（20）提起移液管尖端（94）的阵列，用主洗涤液体填充洗手盆（20），将移液管尖端（94）排列成洗涤盆 （20），运行移液管吸头清洁循环，并产生真空，使得移液管吸头阵列（94）和洗手盆（20）中的主要洗涤液体通过冲洗口（22）阵列排空。