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公开(公告)号：US20160354512A1
公开(公告)日：2016-12-08
申请号：US15102994
申请日：2014-12-10
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen
IPC: A61L26/00
CPC classification number: A61L26/0066 , A61L24/0036 , A61L24/104 , A61L26/0009 , A61L26/0019 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0085 , A61L2300/254 , A61L2300/418 , A61L2400/04 , A61L2430/34
Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.
Abstract translation: 公开了一种干组合物，其包含一种或多种多元醇，其在加入水性介质时形成适合用于止血程序的基本均匀的糊剂。 加入液体后，糊状物自发地重新组成; 因此所述糊状物不需要机械混合。 组合物还可以包含挤出增强剂，例如白蛋白。 还公开了制备所述干组合物的方法，由所述干组合物获得的糊剂以及所述干组合物或糊剂用于医疗和外科用途的用途。
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公开(公告)号：US20160158407A1
公开(公告)日：2016-06-09
申请号：US14980254
申请日：2015-12-28
Applicant: FERROSAN MEDICAL DEVICES A/S
Inventor： Kristian Larsen
CPC classification number: A61L26/0047 , A61K9/1658 , A61K31/047 , A61K31/70 , A61K38/014 , A61L2/04 , A61L2/07 , A61L2/081 , A61L2/082 , A61L2/087 , A61L2/10 , A61L2/202 , A61L2/204 , A61L2/206 , A61L2/208 , A61L24/0015 , A61L24/0036 , A61L24/104 , A61L26/00 , A61L26/0038 , A61L26/0066 , A61L2300/254 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B1/04 , B65D81/32
Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
Abstract translation: 本发明涉及一种干组合物，其在添加水性介质时形成适合用于止血程序的基本均匀的糊状物。 糊剂在加入液体后自发形成，因此不需要机械混合来形成所述糊料。 本发明还涉及制备所述干组合物的方法，由所述干组合物制成的糊剂以及用于医疗和外科用途的所述糊剂的用途。
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公开(公告)号：US12245986B2
公开(公告)日：2025-03-11
申请号：US18491072
申请日：2023-10-20
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen , Peter Lund Hammershøj
IPC: A61J1/20 , A61B17/00 , A61J1/06 , A61M5/162 , A61M5/178 , A61M5/19 , A61M5/20 , A61M5/24 , A61M35/00 , A61M39/00
Abstract: A device for reconstituting a bioactive agent and forming a flowable paste is described. The device comprises a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.
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公开(公告)号：US20240277326A1
公开(公告)日：2024-08-22
申请号：US18568044
申请日：2022-07-14
Applicant: Ferrosan Medical Devices A/S
Inventor： Peter Lund Hammershøj , Henning Uzoma Igwebuike , Lisbeth Nøhr Demant , Christian Brüel , Mikael Engmark , Vikram Kjøller Bhatia , Lars Tamstrup Axelsson , Simon Batchelor
CPC classification number: A61B17/00491 , A61B17/00234 , A61B34/30 , A61B2017/00876 , A61B2017/00946 , A61B2034/301 , A61B2034/305
Abstract: The present disclosure relates to a laparoscopic applicator for dispensing a substance, e.g. a substance comprising a haemostatic agent, at a selected site by means of a surgical robotic arm, the laparoscopic applicator comprising a delivery tube; and an applicator tip connected to a distal end of the delivery tube, wherein the applicator tip is configured for being controllable operated by the robotic arm by a grip section in axial extension of the delivery tube, the grip section having a perimeter transverse to the axis comprising an apex shaped section, such that the grip section is configured for being clamped and spatially manipulated by the robotic arm.
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公开(公告)号：US20210219969A1
公开(公告)日：2021-07-22
申请号：US17056595
申请日：2019-06-26
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen , Peter Lund Hammershøj
Abstract: The invention regards a device for reconstituting a bioactive agent and forming a paste, the device comprising: —a container (2) containing the bioactive agent, —a first syringe (4) containing a liquid, —a second syringe (5) containing a paste forming material, —a connector element (6) configured for establishing sequential fluid connections between 1) the first syringe and the container, 2) the container and the second syringe, and 3) the first and second syringes, such that the liquid can be transferred from the first syringe to the container to reconstitute the bioactive agent, whereupon the reconstituted bioactive agent can be transferred from the container into the second syringe to form a paste, and the paste can be transferred to the first syringe.
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Patent Agency Ranking
公开(公告)号：US20180147355A1
公开(公告)日：2018-05-31
申请号：US15580181
申请日：2016-06-30
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen , Lise Sjørup Elle , Thomas Ingemann Jensen
CPC classification number: A61M5/2066 , A61M5/2448 , A61M5/2459 , A61M5/284 , A61M5/31596 , A61M2005/2086 , A61M2005/31598
Abstract: The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition. In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.
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公开(公告)号：US09724078B2
公开(公告)日：2017-08-08
申请号：US14895674
申请日：2014-06-20
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen , Michael Wrang Mortensen
CPC classification number: A61B17/00491 , A61L26/0038 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/252 , A61L2300/254 , A61L2300/412 , A61L2300/418 , A61L2400/04 , A61L2400/06 , A61M5/19 , A61M5/2448 , A61M5/284 , A61M5/3135 , A61M39/22 , A61M2005/3123 , A61M2005/3132 , C08L89/06
Abstract: The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.
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公开(公告)号：US20150037314A1
公开(公告)日：2015-02-05
申请号：US14516728
申请日：2014-10-17
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen
CPC classification number: A61L26/0047 , A61K9/1658 , A61K31/047 , A61K31/70 , A61K38/014 , A61L2/04 , A61L2/07 , A61L2/081 , A61L2/082 , A61L2/087 , A61L2/10 , A61L2/202 , A61L2/204 , A61L2/206 , A61L2/208 , A61L24/0015 , A61L24/0036 , A61L24/104 , A61L26/00 , A61L26/0038 , A61L26/0066 , A61L2300/254 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B1/04 , B65D81/32
Abstract: Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
Abstract translation: 公开了一种干组合物，其在添加水性介质时形成适用于止血程序的基本均匀的糊剂。 糊剂在加入液体后自发形成，因此不需要机械混合来形成所述糊料。 进一步公开的是制备所述干组合物的方法，由所述干组合物制成的糊剂和所述糊剂用于医疗和外科用途的方法。
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公开(公告)号：US11103616B2
公开(公告)日：2021-08-31
申请号：US16129334
申请日：2018-09-12
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen
Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.
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公开(公告)号：US20210244616A1
公开(公告)日：2021-08-12
申请号：US17056560
申请日：2019-06-26
Applicant: Ferrosan Medical Devices A/S
Inventor： Kristian Larsen , Peter Lund Hammershøj
IPC: A61J1/20
Abstract: The invention regards a device for reconstituting a bioactive agent and forming a flowable paste, the device comprising: a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.
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