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    PEPTIDE NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL
    33.
    发明申请
    PEPTIDE NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL 审中-公开
    肽类核酸及其对遗传物质的影响

    公开(公告)号：WO1993012129A1

    公开(公告)日：1993-06-24

    申请号：PCT/US1992010921

    申请日：1992-12-17

    Applicant: GLAXO INC. ,  THOMSON, Stephen, A. ,  NOBLE, Stewart, A. ,  RICCA, Daniel, J.

    Inventor： GLAXO INC.

    IPC: C07H19/06

    CPC classification number: C07K14/003 ,  A61K38/00 ,  C08G69/10

    Abstract: Peptide nucleic acids oligomers of formula (I) wherein n is 1 or more, particularly about 5-20 and B is independently one of the 4 nucleoside bases or their equivalents, Q and J are end groups useful in anti-sense oligomers and their use in affecting genetic material, e.g. as triplex or antisense in the treatment of disease.

    Abstract translation: 式（I）的肽核酸低聚物，其中n为1或更多，特别是约5-20，B独立地为4个核苷碱基或其等同物之一，Q和J为可用于反义寡聚体的端基及其用途 影响遗传物质，例如 作为治疗疾病的三重或反义。

    CYCLIC ANTITUMOR COMPOUNDS
    34.
    发明申请
    CYCLIC ANTITUMOR COMPOUNDS 审中-公开
    循环抗体化合物

    公开(公告)号：WO1992021661A1

    公开(公告)日：1992-12-10

    申请号：PCT/US1992004611

    申请日：1992-05-28

    Applicant: GLAXO INC.

    Inventor： GLAXO INC. ,  LUZZIO, Michael, J. ,  BESTERMAN, Jeffrey, M. ,  EVANS, Michael, G. ,  JOHNSON, M., Ross ,  DEZUBE, Milana ,  PROFETA, Salvatore, Jr.

    IPC: C07D221/18

    CPC classification number: C07D221/18 ,  C07D471/04 ,  C07D491/04 ,  C07D491/14

    Abstract: The present invention relates to certain substituted tetracyclic fused quinoline derivatives of formula (I), wherein R1 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo, methoxy or amino; R2 is hydrogen, hydroxy, methoxy or amino; R3 is hydrogen, hydroxy, methoxy, methoxymethoxy, amino, -OCONH¿2?, [2(5H)-3,4-dihydro-3-oxyfuranone], 2-hydroxyethoxy, 2-aminoethoxy, 3-hydroxypropoxy or 3-aminopropoxy; or taken together with R?2 or R4¿, methylenedioxy or ethylenedioxy; R4 is hydrogen, hydroxy or amino; Z is -CH¿2?-, -O- or -NH-; and a) X?1¿ is hydrogen; X2 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo or methoxy; and X3 is hydrogen or hydroxy; or b) X2 taken together with X3 is methylenedioxy or etylenedioxy, and X1 is hydrogen or a pharmaceutically acceptable salt thereof provided that: i) at least one of R1 through R4 is other than hydrogen; ii) when R1 is methoxy, R2 is hydroxy or methoxy, R3 is hydrogen or methoxy and R4 is hydrogen; iii) when R2 is hydroxy, methoxy or amino, R3 is hydrogen, hydroxy or methoxy, and R4 is hydrogen; iv) when R4 is hydroxy or amino, R?1 and R3¿ are hydrogen and R2 is hydroxy or amino; and v) when R1 is fluoro, chloro, iodo or amino, R2 is hydrogen, hydroxy or methoxy, R3 is hydrogen, hydroxy or methoxy and R4 is hydrogen and the use of these compounds as topoisomerase inhibitors and antitumor agents.

    System for inspecting and recycling goods from defective packages on a blister packaging machine
    40.
    发明公开
    System for inspecting and recycling goods from defective packages on a blister packaging machine 失效
    设备检查和不合格包装产品的回收率在吸塑包装。

    公开(公告)号：EP0468792A1

    公开(公告)日：1992-01-29

    申请号：EP91306799.7

    申请日：1991-07-25

    Applicant: GLAXO INC.

    Inventor： Evans, Rix Earl ,  Loar, David Wayne

    IPC: B65B57/10 ,  B65B69/00

    CPC classification number: B07C5/3404 ,  B07C5/368 ,  B65B57/10 ,  Y10S53/90

    Abstract: A pneumatic apparatus 10 for withdrawing and recycling goods from defective blister packages on a blister packaging machine comprising a housing 12 which is positioned on the blister packaging machine between the detection station and the sealing station and having a plurality of transversely spaced-apart open chambers 12B in the bottom thereof. A plurality of air valves 14 are connected to a high air pressure source and to the blister package machine detection station, and each air valve 14 corresponds to a respective chamber 12B in the bottom of the housing 12. A plurality of air venturi nozzles 20 are provided wherein each air venturi nozzle 20 is fluidly connected at its air pressure input end 20A to a corresponding air valve 14 and chamber 12B. Each nozzle 20 comprises a goods transportation conduit connected to its air exhaust exhaust end 20B so the air venturi nozzle 20 will create a partial vacuum in the chamber 12B fluidly connected thereto and a pressurized air flow in the goods transportation conduit at the air exhaust end 20B thereof when the air valve 14 corresponding thereto is opened. Upon receiving a signal from the detection station, the pneumatic goods recycling apparatus will pneumatically withdraw the goods from predetermined portions of a carrier strip from which blister sections will be separated and which each have at least one empty cell therein and then propel the goods back to the blister packaging machine hopper.

    Abstract translation: 用于取出和从泡罩包装机上有缺陷的泡罩包装可回收产品，其包括一个壳体12的所有被检测站和密封站和具有横向间隔开的开放室12B的之间的多个定位在所述泡罩包装机上的充气装置10 在其底部。 空气阀14中的多个被连接到一个高的空气压力源和所述泡罩包装机的检测站，并且每个空气阀14对应于respectivement室12B在壳体12的空气的文丘里喷嘴的多个20的底部 提供worin每个空气文杜里喷嘴20在其空气压力输入端部20A对应的空气阀14和室12B流体连接。 每个喷嘴20包括连接到其排气的排气端20B作为空气文丘里喷嘴20中的货物运输导管将在室12B与其流体地连接，并在货物运输导管在所述排气端20B的加压空气流局部真空 它们当空气阀14被打开与其对应。 在从检测站接收的信号时，充气产品回收设备将气动从载体带的预定部分撤回货物从哪个泡罩部分将被分离，并且每一个具有至少一个空单元。其中，然后推动产品回 泡罩包装机料斗。

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