公开(公告)号：US06868347B2

公开(公告)日：2005-03-15

申请号：US10393109

申请日：2003-03-19

Applicant: Guann-Pyng Li ,  Mark Bachman ,  Zhongping Chen

Inventor： Guann-Pyng Li ,  Mark Bachman ,  Zhongping Chen

IPC: G01B9/02 ,  G01N11/00

CPC classification number: G06F19/00 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02045 ,  G01B9/02072 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70

Abstract: A system integration of multicomponent technologies includes an automated microfluidic probe station and the use of that station for the systematic study of nonideal, nonhomogeneous biological fluids such as blood in microfluidic chips. The probe station provides for real-time, non-invasive metrology of microfluidic chips employing optical coherence tomography and optical Doppler tomography to allow for collection of flow data at any location or depth within a microfluidics chip. Also included is a programmable fluidic loader and actuator platform as part of the probe station, and a semi-automated rapid prototyping tool used to fabricate the microfluidic chips measured on the probe station. The resulting data library produced by measurements on the probe station contains all the necessary information needed to develop mature, accurate microfluidic modeling and simulation CAD tools.

Abstract translation: 多组分技术的系统集成包括自动化微流体探针站和该站的用途，用于系统研究非流体，非均质生物流体，如微流控芯片中的血液。 探针台提供使用光学相干断层扫描和光学多普勒层析成像的微流控芯片的实时非侵入式计量，以允许在微流体芯片内的任何位置或深度收集流量数据。 还包括作为探测台的一部分的可编程流体装载器和致动器平台，以及用于制造在探针台上测量的微流体芯片的半自动化快速成型工具。 通过探针台上的测量产生的结果数据库包含开发成熟，精确的微流体建模和仿真CAD工具所需的全部必要信息。

公开(公告)号：US09685291B2

公开(公告)日：2017-06-20

申请号：US13415840

申请日：2012-03-08

Applicant: Mark Bachman ,  Guann-Pyng Li ,  Minfeng Wang ,  Yang Zhang ,  Brent Puohan Lin

Inventor： Mark Bachman ,  Guann-Pyng Li ,  Minfeng Wang ,  Yang Zhang ,  Brent Puohan Lin

IPC: H01H51/32 ,  H01H50/00 ,  G02B26/08 ,  H01H1/00 ,  H01H59/00

CPC classification number: H01H50/005 ,  G02B26/0833 ,  H01H2001/0042 ,  H01H2001/0084 ,  H01H2059/0036

Abstract: Frequency addressable micro-actuators having one or more movable resonating elements actuators, such as cantilevers, can be forced into oscillation by, e.g., electromagnetic actuation. The movable structure is designed to latch at a certain amplitude using one of several latching techniques, such as a near-field magnetic field. In operation, the movable element is driven into resonance, producing a large amplitude, which results in the structure latching. Through resonance, a small force applied in a repeating manner can result in the latching of the actuator, an operation which would normally require a large force. If two or more units, each with different harmonic frequencies, are placed under the same influence, only the one with a harmonic response to the driving force will latch. A single influencing signal may be used to latch more than one device on demand by tuning the frequency to match the natural frequency of the device of interest.

公开(公告)号：US08877074B2

公开(公告)日：2014-11-04

申请号：US12112925

申请日：2008-04-30

Applicant: Mark Bachman ,  Guann-Pyng Li

Inventor： Mark Bachman ,  Guann-Pyng Li

IPC: B32B37/02 ,  H01B13/00 ,  B81C1/00

CPC classification number: B32B37/02 ,  B81B2203/0109 ,  B81B2203/0118 ,  B81C1/00182 ,  B81C1/00253 ,  Y10T156/10 ,  Y10T156/1043

Abstract: Systems and methods for producing micromachined devices, including sensors, actuators, optics, fluidics, and mechanical assemblies, using manufacturing techniques of lead frames, substrates, microelectronic packages, printed circuit boards, flex circuits, and rigid-flex materials. Preferred embodiments comprise using methods from post-semiconductor manufacturing to produce three-dimensional and free-standing structures in non-semiconductor materials. The resulting devices may remain part of the substrate, board or lead frame which can then used as a substrate for further packaging electronic assembly operations. Alternatively, the devices may be used as final components that can be assembled within other devices.

Abstract translation: 使用引线框架，衬底，微电子封装，印刷电路板，柔性电路和刚性 - 柔性材料的制造技术来生产微加工器件的系统和方法，包括传感器，致动器，光学器件，流体学和机械组件。 优选实施例包括使用后半导体制造中的方法，以在非半导体材料中制造三维和独立结构。 所得到的装置可以保持为基板，板或引线框架的一部分，然后可以将其用作用于进一步封装电子组装操作的基板。 或者，装置可以用作可以在其他装置内组装的最终部件。

公开(公告)号：US08824707B2

公开(公告)日：2014-09-02

申请号：US13340240

申请日：2011-12-29

Applicant: Mark Bachman ,  Guann-Pyng Li Li

Inventor： Mark Bachman ,  Guann-Pyng Li Li

IPC: H04R31/00 ,  H04R19/00

CPC classification number: H04R19/005 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2924/01079 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/00014 ,  H01L2924/00

Abstract: A micromachined microphone or speaker embedded within, or positioned on top of, a substrate suitable for carrying microelectronic chips and components. The acoustic element converts sound energy into electrical energy which is then amplified by electronic components positioned on the surface of the substrate. Alternatively, the acoustic element may be driven by electronics to produce sound. The substrate can be used in standard microelectronic packaging applications.

Abstract translation: 嵌入在适于承载微电子芯片和部件的基板内或位于其上的微机械麦克风或扬声器。 声学元件将声能转换成电能，然后由位于基板表面上的电子部件放大。 或者，声学元件可以由电子器件驱动以产生声音。 该基板可用于标准微电子封装应用。

公开(公告)号：US07951580B2

公开(公告)日：2011-05-31

申请号：US11112407

申请日：2005-04-21

Applicant: Guann-Pyng Li ,  Mark Bachman ,  Nancy Allbritton ,  Chris Sims ,  Cynthia Jensen-McMullin

Inventor： Guann-Pyng Li ,  Mark Bachman ,  Nancy Allbritton ,  Chris Sims ,  Cynthia Jensen-McMullin

IPC: C12Q1/68 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00

CPC classification number: B01L3/545 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/043 ,  G01N15/1459 ,  G01N2015/149

Abstract: Systems and methods are providing for performing high-throughput, programmable, multiplexed assays of biological, chemical or biochemical systems. Preferably, a micro-pallet includes a small flat surface designed for single adherent cells to plate, a cell plating region designed to protect the cells, and shaping designed to enable or improve flow-through operation. The micro-pallet is preferably patterned in a readily identifiable manner and sized to accommodate a single cell to which it is comparable in size. Each cell thus has its own mobile surface. The cell can be transported from place to place and be directed into a system similar to a flow cytometer. Since, since the surface itself may be tagged (e.g., a bar code), multiple cells of different origin and history may be placed into the same experiment allowing multiplexed experiments to be performed.

Abstract translation: 系统和方法正在提供用于执行生物，化学或生化系统的高通量，可编程多路复用测定。 优选地，微托盘包括设计用于单个贴壁细胞板的小平坦表面，设计用于保护细胞的细胞电镀区域和被设计成能够或改善流通操作的整形。 微型托盘优选以易于识别的方式图案化并且尺寸适于容纳其尺寸相当的单个单元。 因此，每个单元具有其自己的移动表面。 细胞可以从一个地方运送到另一个地方，并被引导到类似于流式细胞仪的系统中。 由于表面本身可以被标记（例如，条形码），因此可以将不同来源和历史的多个单元放置在相同的实验中，从而允许执行复用实验。

公开(公告)号：US07884689B2

公开(公告)日：2011-02-08

申请号：US11428446

申请日：2006-07-03

Applicant: Bedri A. Cetiner ,  Mark Bachman ,  Guann-Pyng Li ,  Jiangyuan Qian ,  Hung-Pin Chang ,  Franco De Flaviis

Inventor： Bedri A. Cetiner ,  Mark Bachman ,  Guann-Pyng Li ,  Jiangyuan Qian ,  Hung-Pin Chang ,  Franco De Flaviis

IPC: H01H51/22

CPC classification number: H01Q1/38

Abstract: Systems and methods are provided that facilitate the formation of micro-mechanical structures and related systems on a laminated substrate. More particularly, a micro-mechanical device and a three-dimensional multiple frequency antenna are provided for in which the micro-mechanical device and antenna, as well as additional components, can be fabricated together concurrently on the same laminated substrate. The fabrication process includes a low temperature disposition process allowing for deposition of an insulator material at a temperature below the maximum operating temperature of the laminated substrate, as well as a planarization process allowing for the molding and planarizing of a polymer layer to be used as a form for a micro-mechanical device.

Abstract translation: 提供了有助于在层压基板上形成微机械结构和相关系统的系统和方法。 更具体地，提供了微机械装置和三维多频天线，其中微机械装置和天线以及附加部件可以在同一叠层基板上同时制造在一起。 该制造工艺包括一种低温配置工艺，其允许在低于层合基板的最大工作温度的温度下沉积绝缘体材料，以及允许将聚合物层的模制和平面化用作为 形式用于微机械装置。

公开(公告)号：US07811443B2

公开(公告)日：2010-10-12

申请号：US10967913

申请日：2004-10-18

Applicant: Mark Bachman ,  Guann-Pyng Li ,  Liang Wu

Inventor： Mark Bachman ,  Guann-Pyng Li ,  Liang Wu

IPC: B01D3/42

CPC classification number: B01D19/0073 ,  B01D1/14 ,  B01D3/009 ,  B01D3/12 ,  B01D5/0027 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/10 ,  B01L2300/1822 ,  B01L2300/1861

Abstract: A microfluidic dynamic vapor control system adapted to change the chemistry of small drops by dynamically controlling the vapor content surrounding the drops. The small volume surface area ratio makes this an efficient mechanism for controlling chemistry in nanovolumes. The system uses small reservoirs of material that can produce vapor on demand, and microfluidic channels that direct the vapor into a small chamber that holds a drop of the solution of interest. By changing the vapors that enter the chamber, the chemical composition of the drop can be modified.

Abstract translation: 一种微流体动态蒸汽控制系统，其适于通过动态地控制液滴周围的蒸气含量来改变小液滴的化学性质。 体积小的表面积比使其成为控制纳米体系化学的有效机制。 该系统使用可以根据需要产生蒸气的小储层材料，以及将蒸汽引导到保持一滴感兴趣的溶液的小室的微流体通道。 通过改变进入室的蒸气，可以改变液滴的化学成分。

公开(公告)号：US07773355B2

公开(公告)日：2010-08-10

申请号：US11533330

申请日：2006-09-19

Applicant: Yintat Ma ,  Guann-Pyng Li

Inventor： Yintat Ma ,  Guann-Pyng Li

IPC: H02H9/00

CPC classification number: H03F1/52 ,  H01L27/0255 ,  H03F3/3435 ,  H03F2200/444

Abstract: Improved protection circuits are provided for use as voltage overload protection circuits, ESD protection circuits for RF input pins, and unit protection cells for distributed amplifiers. Preferably, the protection circuits include a positive threshold voltage trigger used to trigger a switch wherein the trigger includes a diode string in series with a resistor and the switch includes a bipolar transistor switch in series with a diode. Alternatively, the trigger includes a diode string in series with a single diode and a single resistor, and is used to trigger a Darlington pair transistor switch in series with a diode. In another embodiment, a Darlington pair transistor switch is triggered by a capacitor. In use with distributed amplifiers, the ESD protection circuits are preferably absorbed inside the artificial transmission lines of the distributed amplifier.

Abstract translation: 提供改进的保护电路用作电压过载保护电路，RF输入引脚的ESD保护电路和用于分布式放大器的单元保护单元。 优选地，保护电路包括用于触发开关的正阈值电压触发器，其中触发器包括与电阻器串联的二极管串，并且开关包括与二极管串联的双极晶体管开关。 或者，触发器包括与单个二极管和单个电阻器串联的二极管串，并且用于触发与二极管串联的达林顿对晶体管开关。 在另一个实施例中，达林顿对晶体管开关由电容器触发。 在与分布式放大器一起使用时，ESD保护电路优选地被吸收在分布式放大器的人造传输线内部。

公开(公告)号：US07759119B2

公开(公告)日：2010-07-20

申请号：US11733053

申请日：2007-04-09

Applicant: Nancy Allbritton ,  Christopher E. Sims ,  Yuli Wang ,  Mark Bachman ,  Guann-Pyng Li ,  Eric Stanbridge

Inventor： Nancy Allbritton ,  Christopher E. Sims ,  Yuli Wang ,  Mark Bachman ,  Guann-Pyng Li ,  Eric Stanbridge

IPC: C12N15/00 ,  C12N5/02 ,  C12N5/00 ,  C12N15/01 ,  C12N1/02

CPC classification number: G01N1/286 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0829 ,  C12M23/12 ,  C12M47/04 ,  G01N2001/2886

Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.

Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。 板的使用有利于基于动态现象和快速建立稳定的转染剂来选择和分选细胞。

公开(公告)号：US07602240B2

公开(公告)日：2009-10-13

申请号：US11911800

申请日：2006-04-28

Applicant: Huai Gao ,  Haitao Zhang ,  Guann-Pyng Li

Inventor： Huai Gao ,  Haitao Zhang ,  Guann-Pyng Li

IPC: H03F1/24

CPC classification number: H03F3/191 ,  H03F1/565 ,  H03F3/195 ,  H03F3/211 ,  H03F3/602 ,  H03F2200/111 ,  H03F2200/225 ,  H03F2200/318 ,  H03F2200/36 ,  H03F2200/391 ,  H03H7/38

Abstract: Provided herein is a power amplifier having a multiple stage power amplifier section and an output matching network section. The multiple stage power amplifier section can include multiple power amplifier stages with interstage matching circuits located therebetween. The output matching network can be configured to match the multiple stage power amplifier section at multiple different frequencies or frequency bands. The power amplifier device is capable of selective operation within one of multiple different frequencies or frequency bands.

Abstract translation: 本文提供的是具有多级功率放大器部分和输出匹配网络部分的功率放大器。 多级功率放大器部分可以包括多个功率放大器级，其间具有级间匹配电路。 输出匹配网络可以配置为在多个不同频率或频带上匹配多级功率放大器部分。 功率放大器装置能够在多个不同频率或频带之一内进行选择性操作。