公开(公告)号：WO2007060140A2

公开(公告)日：2007-05-31

申请号：PCT/EP2006/068611

申请日：2006-11-17

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David Robert ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  HAMILTON, Matthew Michael ,  LI, Shiming ,  MCDERMOTT, Lee Apostle ,  QIAN, Yimin ,  YUN, Weiya

Inventor： BOLIN, David Robert ,  CHEUNG, Adrian Wai-Hing ,  FIROOZNIA, Fariborz ,  HAMILTON, Matthew Michael ,  LI, Shiming ,  MCDERMOTT, Lee Apostle ,  QIAN, Yimin ,  YUN, Weiya

CPC classification number: C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2005049018A1

公开(公告)日：2005-06-02

申请号：PCT/US2004/038566

申请日：2004-11-15

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  HADIDA RUAH, Sarah, S ,  MILLER, Mark, T. ,  GROOTENHUIS, Peter, D., J. ,  HAMILTON, Matthew?

Inventor： HADIDA RUAH, Sarah, S ,  MILLER, Mark, T. ,  GROOTENHUIS, Peter, D., J. ,  HAMILTON, Matthew?

IPC: A61K31/42

CPC classification number: C07D263/34 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  C07D277/56 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2005026137A2

公开(公告)日：2005-03-24

申请号：PCT/US2004/029206

申请日：2004-09-07

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CLEVELAND, Thomas ,  MAKINGS, Lewis R. ,  HAMILTON, Matthew ,  GROOTENHUIS, Peter D.J. ,  MILLER, Mark T. ,  HADIDA RUAH, Sara S. ,  SINGH, Ashavini K.

Inventor： MILLER, Mark T. ,  HADIDA RUAH, Sara S. ,  SINGH, Ashavini K.

IPC: C07D277/82

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP-结合盒（“ABC”）转运蛋白或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2003095194A1

公开(公告)日：2003-11-20

申请号：PCT/US2002/039490

申请日：2002-12-09

Applicant: HAMILTON, Matthew

Inventor： HAMILTON, Matthew ,  WALTERS, Russel ,  KINNIER, Alex

IPC: B32B07/00

CPC classification number: B82Y30/00 ,  B05D1/185 ,  B05D5/04 ,  B05D5/06 ,  B41M1/30 ,  B41M1/34 ,  B41M3/003 ,  Y10T428/24802

Abstract: It is an object of the present invention to provide novel signs and visual displays produced by different behavior of liquids applied to hydrophilic and hydrophobic surfaces on patterned surfaces. It is also an object of the present invention to provide articles baring logos and alphanumeric text produced by application of liquids to patterned material surfaces. There is further provided a method for producing novel signs and visual displays by producing patterned hydrophobic and hydrophilic surfaces. Also provided are processes for producing patterned surfaces.

Abstract translation: 本发明的目的是提供通过在图案化表面上施加到亲水和疏水表面上的液体的不同行为产生的新型符号和视觉显示。 本发明的另一个目的是提供通过将液体施加到图案化材料表面而产生的制品徽标和字母数字文本。 进一步提供了通过产生图案化的疏水和亲水表面来生产新颖的符号和视觉显示的方法。 还提供了用于产生图案化表面的工艺。