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31.发明申请COMBINATION FOR USE IN TREATING DISEASES OR CONDITIONS ASSOCIATED WITH MELANOMA, OR TREATING DISEASES OR CONDITIONS ASSOCIATED WITH ACTIVATED B-RAF PATHWAY 审中-公开用于治疗与MELANOMA相关的疾病或病症的组合或治疗与激活的B-RAF途径相关的疾病或病症
公开(公告)号：WO2014072357A1
公开(公告)日：2014-05-15
申请号：PCT/EP2013/073192
申请日：2013-11-06
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713
CPC classification number: A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , C12N15/1135 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12N2330/10 , A61K2300/00
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。
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公开(公告)号：EP3800256A1
公开(公告)日：2021-04-07
申请号：EP20190754.0
申请日：2013-11-06
Applicant: InteRNA Technologies B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
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公开(公告)号：EP3369818A1
公开(公告)日：2018-09-05
申请号：EP18167556.2
申请日：2012-12-20
Applicant: InteRNA Technologies B.V. , Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg
Inventor： Brakenhoff, Rudolf Henrikus , van der Plas, Marlon , de Kemp, Sanne Rosaly , Gommans, Willemijn Maria , Prevost, Grégoire Pierre André , Schaapveld, Roeland Quirinus Jozef , Cerisoli, Francesco
IPC: C12N15/113 , A61K31/713 , A61P35/00
CPC classification number: C12N15/113 , C12N2310/141 , C12N2320/31
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-342 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change
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公开(公告)号：EP3360966A1
公开(公告)日：2018-08-15
申请号：EP18164043.4
申请日：2012-01-10
Applicant: InteRNA Technologies B.V.
Inventor： Weijzen, Sanne , Schaapveld, Roeland Quirinus Jozef , Bourajjaj, Meriem , van Haastert, Rick Jan , Griffioen, Arjan Willem , van Beijnum, Judith Rosina , Cuppen, Edwin Pieter Johan Gerard , Berezikov, Eugene , van Puijenbroek, Andreas Alphons Franciscus Ludovicus , Gommans, Willemijn Maria , Babae, Negar , van Noort, Petronella Innocentia
IPC: C12N15/113 , A61K31/7105 , A61K31/713 , A61P35/00
CPC classification number: C12N15/1135 , A61P35/00 , C12N7/00 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2320/31 , C12N2710/10043 , C12N2740/15043 , C12Q1/6883 , C12Q1/6886
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
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公开(公告)号：EP2870263A1
公开(公告)日：2015-05-13
申请号：EP13739851.7
申请日：2013-07-03
Applicant: InteRNA Technologies B.V.
Inventor： VAN ZONNEVELD, Anton Jan , DUIJS, Jacques , KUIPER, Johan , ZWEERS, Thijs Jan , JUKEMA, Johan Wouter , BEREZIKOV, Eugene
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules,complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.
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Patent Agency Ranking36.发明授权A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT 有权miRNA分子通过其源定义，它的治疗用途EMT相关癌症
公开(公告)号：EP2542678B1
公开(公告)日：2017-04-12
申请号：EP11708936.7
申请日：2011-03-04
Applicant: InteRNA Technologies B.V.
Inventor： SCHAAPVELD, Roeland Quirinus Jozef , VERHAEGH, Gerardus Wilhelmus Christiaan Theodoor , SCHALKEN, Jacobus Antonius , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria , WEIJZEN, Sanne
IPC: C12N15/113 , A61K31/713 , A61K31/7105 , A61P35/04
CPC classification number: C12N15/1138 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/113 , C12N2310/141 , C12N2320/31 , C12N2330/10
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
Abstract translation: 本发明涉及一种miRNA分子或等效的诊断和治疗用途worin的所述miRNA分子或其等价物包含至少80个核苷酸的来源，并且包括具有由SEQ ID代表的基序具有至少98％同一性的基序NO 1或者与EMT相关的疾病和状况其源极（上皮至间质转变）。
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公开(公告)号：EP2794881A1
公开(公告)日：2014-10-29
申请号：EP12819153.3
申请日：2012-12-20
Applicant: InteRNA Technologies B.V. , Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg
Inventor： BRAKENHOFF, Rudolf Henrikus , VAN DER PLAS, Marlon , DE KEMP, Sanne Rosaly , GOMMANS, Willemijn Maria , PREVOST, Grégoire Pierre André , SCHAAPVELD, Roeland Quirinus Jozef , CERISOLI, Francesco
IPC: C12N15/113 , A61K31/713 , A61P35/00
CPC classification number: C12N15/113 , C12N2310/141 , C12N2320/31
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
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公开(公告)号：EP3214174B1
公开(公告)日：2019-10-16
申请号：EP17165861.0
申请日：2011-03-04
Applicant: InteRNA Technologies B.V.
Inventor： Schaapveld, Roeland Quirinus Jozef , Verhaegh, Gerardus Wilhelmus Christiaan Theodoor , Schalken, Jacobus Antonius , van Puijenbroek, Andreas Alphons Franciscus L. , Gommans, Willemijn Maria , Weijzen, Sanne
IPC: C12N15/113 , A61K31/7105 , A61P35/04 , A61K31/713
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39.发明授权MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS 有权MIRNA用于治疗与新血管发生有关的疾病和病症
公开(公告)号：EP2663641B1
公开(公告)日：2018-03-28
申请号：EP12703604.4
申请日：2012-01-10
Applicant: InteRNA Technologies B.V.
Inventor： WEIJZEN, Sanne , SCHAAPVELD, Roeland Quirinus Jozef , BOURAJJAJ, Meriem , VAN HAASTERT, Rick Jan , GRIFFIOEN, Arjan Willem , VAN BEIJNUM, Judith Rosina , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria , BABAE, Negar , VAN NOORT, Petronella Innocentia
IPC: C12N15/113 , A61K31/7105 , A61K31/713 , A61P35/00
CPC classification number: C12N15/1135 , A61P35/00 , C12N7/00 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2320/31 , C12N2710/10043 , C12N2740/15043 , C12Q1/6883 , C12Q1/6886
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-574 molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
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40.发明公开A MIRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT 审中-公开以其来源定义的MIRNA分子及其在与EMT有关的疾病或病症中的诊断和治疗用途
公开(公告)号：EP3214174A1
公开(公告)日：2017-09-06
申请号：EP17165861.0
申请日：2011-03-04
Applicant: InteRNA Technologies B.V.
Inventor： Schaapveld, Roeland Quirinus Jozef , Verhaegh, Gerardus Wilhelmus Christiaan Theodoor , Schalken, Jacobus Antonius , van Puijenbroek, Andreas Alphons Franciscus L. , Gommans, Willemijn Maria , Weijzen, Sanne
IPC: C12N15/113 , A61K31/7105 , A61P35/04 , A61K31/713
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
Abstract translation: 本发明涉及miRNA分子或其等同物的诊断和治疗用途，其中所述miRNA分子或其等同物的来源包含至少80个核苷酸，并且包含与由SEQ ID NO代表的基序具有至少98％同一性的基序 ：1或其来源于与EMT（上皮间质转化）相关的疾病和病症中。
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