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1.发明申请MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS 审中-公开用于治疗与新生血管发生相关的疾病和病症的MIRNA
公开(公告)号：WO2012096573A1
公开(公告)日：2012-07-19
申请号：PCT/NL2012/050011
申请日：2012-01-10
Applicant: INTERNA TECHNOLOGIES B.V. , WEIJZEN, Sanne , SCHAAPVELD, Roeland Quirinus Jozef , BOURAJJAJ, Meriem , VAN HAASTERT, Rick Jan , GRIFFIOEN, Arjan Willem , VAN BEIJNUM, Judith Rosina , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria
Inventor： WEIJZEN, Sanne , SCHAAPVELD, Roeland Quirinus Jozef , BOURAJJAJ, Meriem , VAN HAASTERT, Rick Jan , GRIFFIOEN, Arjan Willem , VAN BEIJNUM, Judith Rosina , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria
IPC: C12N15/113 , A61K31/7105 , A61K31/713 , A61P35/00
CPC classification number: C12N15/1135 , A61P35/00 , C12N7/00 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2320/31 , C12N2710/10043 , C12N2740/15043 , C12Q1/6883 , C12Q1/6886
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。
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公开(公告)号：WO2014007623A1
公开(公告)日：2014-01-09
申请号：PCT/NL2013/050491
申请日：2013-07-03
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： VAN ZONNEVELD, Anton Jan , DUIJS, Jacques , KUIPER, Johan , ZWEERS, Thijs Jan , JUKEMA, Johan Wouter , BEREZIKOV, Eugene
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules,complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.
Abstract translation: 由分离的核酸分子，其补体和/或其片段组成或由其组成的诊断组合，所述核酸分子，补体，等同物和/或片段由包含具有至少80％的序列同一性的序列组成或由其组成的序列表示 具有SEQ ID NO：1-92或49-140或其衍生物（即组a），b），c），d），e），f），g），h），i）或j）或亚组 ）及其用途。
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公开(公告)号：WO2015194956A1
公开(公告)日：2015-12-23
申请号：PCT/NL2015/050449
申请日：2015-06-19
Applicant: STICHTING VU-VUMC , INTERNA TECHNOLOGIES B.V.
Inventor： MEIJER, Gerrit Albert , DIOSDADO, Begoña , TIMMER, Lisette M. , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , CERISOLI, Francesco , SCHAAPVELD, Roeland Quirinus Jozef
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和装置以及生物标志物的用途。 描述的生物标志物在粪便中可靠地检测，并且与结肠直肠癌阴性患者相比，在结肠直肠癌患者中表现出显着不同的表达水平。
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4.发明申请COMBINATION FOR USE IN TREATING DISEASES OR CONDITIONS ASSOCIATED WITH MELANOMA, OR TREATING DISEASES OR CONDITIONS ASSOCIATED WITH ACTIVATED B-RAF PATHWAY 审中-公开用于治疗与MELANOMA相关的疾病或病症的组合或治疗与激活的B-RAF途径相关的疾病或病症
公开(公告)号：WO2014072357A1
公开(公告)日：2014-05-15
申请号：PCT/EP2013/073192
申请日：2013-11-06
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713
CPC classification number: A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , C12N15/1135 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12N2330/10 , A61K2300/00
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。
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公开(公告)号：EP3800256A1
公开(公告)日：2021-04-07
申请号：EP20190754.0
申请日：2013-11-06
Applicant: InteRNA Technologies B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
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Patent Agency Ranking
公开(公告)号：EP2870263A1
公开(公告)日：2015-05-13
申请号：EP13739851.7
申请日：2013-07-03
Applicant: InteRNA Technologies B.V.
Inventor： VAN ZONNEVELD, Anton Jan , DUIJS, Jacques , KUIPER, Johan , ZWEERS, Thijs Jan , JUKEMA, Johan Wouter , BEREZIKOV, Eugene
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules,complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.
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7.发明授权MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS 有权MIRNA用于治疗与新血管发生有关的疾病和病症
公开(公告)号：EP2663641B1
公开(公告)日：2018-03-28
申请号：EP12703604.4
申请日：2012-01-10
Applicant: InteRNA Technologies B.V.
Inventor： WEIJZEN, Sanne , SCHAAPVELD, Roeland Quirinus Jozef , BOURAJJAJ, Meriem , VAN HAASTERT, Rick Jan , GRIFFIOEN, Arjan Willem , VAN BEIJNUM, Judith Rosina , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria , BABAE, Negar , VAN NOORT, Petronella Innocentia
IPC: C12N15/113 , A61K31/7105 , A61K31/713 , A61P35/00
CPC classification number: C12N15/1135 , A61P35/00 , C12N7/00 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2320/31 , C12N2710/10043 , C12N2740/15043 , C12Q1/6883 , C12Q1/6886
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-574 molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
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8.发明公开MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS 有权US ANG ANG ANG E E E E E E E E E E E E E E E E E E E E E E E E E E E E E E E E E E
公开(公告)号：EP2663641A1
公开(公告)日：2013-11-20
申请号：EP12703604.4
申请日：2012-01-10
Applicant: InteRNA Technologies B.V.
Inventor： WEIJZEN, Sanne , SCHAAPVELD, Roeland Quirinus Jozef , BOURAJJAJ, Meriem , VAN HAASTERT, Rick Jan , GRIFFIOEN, Arjan Willem , VAN BEIJNUM, Judith Rosina , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , VAN PUIJENBROEK, Andreas Alphons Franciscus Ludovicus , GOMMANS, Willemijn Maria , BABAE, Negar , VAN NOORT, Petronella Innocentia
IPC: C12N15/113 , A61K31/7105 , A61K31/713 , A61P35/00
CPC classification number: C12N15/1135 , A61P35/00 , C12N7/00 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2320/31 , C12N2710/10043 , C12N2740/15043 , C12Q1/6883 , C12Q1/6886
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-574 molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA-574分子，其等同物或来源的诊断和治疗用途。
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公开(公告)号：EP3158083A1
公开(公告)日：2017-04-26
申请号：EP15738759.8
申请日：2015-06-19
Applicant: Stichting VU-VUmc , InteRNA Technologies B.V.
Inventor： MEIJER, Gerrit Albert , DIOSDADO, Begoña , TIMMER, Lisette M. , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , CERISOLI, Francesco , SCHAAPVELD, Roeland Quirinus Jozef
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和设备以及生物标志物的用途。 所描述的生物标志物在大便中可靠地检测到，并且与结肠直肠癌阴性患者相比在结肠直肠癌患者中表现出显着不同的表达水平。
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10.发明公开COMBINATION FOR USE IN TREATING DISEASES OR CONDITIONS ASSOCIATED WITH MELANOMA, OR TREATING DISEASES OR CONDITIONS ASSOCIATED WITH ACTIVATED B-RAF PATHWAY 审中-公开融合对患有黑色素瘤或与其相关的疾病和病症的治疗有关的疾病或病症的治疗激活的B-RAF信号
公开(公告)号：EP2917348A1
公开(公告)日：2015-09-16
申请号：EP13788743.6
申请日：2013-11-06
Applicant: InteRNA Technologies B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713
CPC classification number: A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , C12N15/1135 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12N2330/10 , A61K2300/00
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract translation: 本发明涉及与黑素瘤或疾病或与活化的BRAF途径相关的病症有关的疾病和病症的治疗用途的组合。
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