公开(公告)号：WO2002006345A3

公开(公告)日：2002-01-24

申请号：PCT/US2001/022637

申请日：2001-07-18

Applicant: CURAGEN CORPORATION ,  ZERHUSEN, Bryan ,  PADIGARU, Muralidhara ,  LI, Li ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  SPYTEK, Kimberly, A. ,  MISHRA, Vishnu ,  TAYLOR, Sarah ,  SHENOY, Suresh ,  VERNET, Corine ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John, R. ,  STONE, David ,  SMITHSON, Glennda ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  TCHERNEV, Velizar, T. ,  TAILLON, Bruce

Inventor： ZERHUSEN, Bryan ,  PADIGARU, Muralidhara ,  LI, Li ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  SPYTEK, Kimberly, A. ,  MISHRA, Vishnu ,  TAYLOR, Sarah ,  SHENOY, Suresh ,  VERNET, Corine ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John, R. ,  STONE, David ,  SMITHSON, Glennda ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  TCHERNEV, Velizar, T. ,  TAILLON, Bruce

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-proteincoupled-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospeficically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human acids and proteins.

公开(公告)号：WO2002006339A3

公开(公告)日：2002-01-24

申请号：PCT/US2001/021249

申请日：2001-07-03

Applicant: CURAGEN CORPORATION ,  SPADERNA, Steven, K. ,  TCHERNEV, Velizar ,  LIU, Xiaohong ,  SHENOY, Suresh ,  SPYTEK, Kimberly ,  ZERHUSEN, Bryan ,  PATTURAJAN, Meera ,  TAUPIER, Raymond, J. ,  RASTELLI, Luca ,  GROSSE, William, M. ,  SZEKERES, Edward, S. ,  ALSOBROOK, John, II ,  LEPLEY, Denise, M. ,  SHEN, Lei ,  BURGESS, Catherine, E. ,  SHIMKETS, Richard, A. ,  PADIGARU, Muralidhara

Inventor： SPADERNA, Steven, K. ,  TCHERNEV, Velizar ,  LIU, Xiaohong ,  SHENOY, Suresh ,  SPYTEK, Kimberly ,  ZERHUSEN, Bryan ,  PATTURAJAN, Meera ,  TAUPIER, Raymond, J. ,  RASTELLI, Luca ,  GROSSE, William, M. ,  SZEKERES, Edward, S. ,  ALSOBROOK, John, II ,  LEPLEY, Denise, M. ,  SHEN, Lei ,  BURGESS, Catherine, E. ,  SHIMKETS, Richard, A. ,  PADIGARU, Muralidhara

IPC: C12N15/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polpeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2005113809A3

公开(公告)日：2009-05-14

申请号：PCT/US2005010731

申请日：2005-03-29

Applicant: CURAGEN CORP ,  ALSOBROOK JOHN II ,  BOLDOG FERENC L ,  JEFFERS MICHAEL E ,  LAROCHELLE WILLIAM J ,  LEPLEY DENISE M ,  LICHENSTEIN HENRI ,  SHIMKETS RICHARD A ,  YANG MEIJIA ,  RUIZ-MARTINEZ MARIE ,  CHERNAYA GALINA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS ,  ZHONG MEI

Inventor： ALSOBROOK JOHN II ,  BOLDOG FERENC L ,  JEFFERS MICHAEL E ,  LAROCHELLE WILLIAM J ,  LEPLEY DENISE M ,  LICHENSTEIN HENRI ,  SHIMKETS RICHARD A ,  YANG MEIJIA ,  RUIZ-MARTINEZ MARIE ,  CHERNAYA GALINA ,  PADIGARU MURALIDHARA ,  PRAYAGA SUDHIRDAS ,  ZHONG MEI

IPC: C12N1/13 ,  A61K38/18 ,  C07K14/475 ,  C07K14/50 ,  C12N5/10 ,  C12N15/01 ,  C12N15/12 ,  C12N15/63 ,  C12Q1/68

CPC classification number: A61K38/1825 ,  C07K14/50

Abstract: The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

Abstract translation: 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

公开(公告)号：WO2005044991A3

公开(公告)日：2009-04-02

申请号：PCT/US2004036478

申请日：2004-11-03

Applicant: CURAGEN CORP ,  ALSOBROOK JOHN II ,  EICHEN JOSEPH ,  LEPLEY DENISE M ,  MILLER CHARLES E ,  MEZES PETER

Inventor： ALSOBROOK JOHN II ,  EICHEN JOSEPH ,  LEPLEY DENISE M ,  MILLER CHARLES E ,  MEZES PETER

IPC: C12N15/00 ,  C07K14/00 ,  C07K14/50 ,  C12N20060101 ,  C12N15/11 ,  C12N15/85

CPC classification number: C07K14/50

Abstract: The present invention generally relates to compositions and methods of use for a fibroblast growth factor ("FGF"). More particularly, the present invention relates to a nucleotide polymorphism (SNP) of FGF-20, and its fragments, derivatives, variants, homologs, and analogs, as well as their uses in wound healing, and prevention and/or treatment of certain diseases, including but are not limited to, stroke, radiation sickness, mucositis, inflammatory bowel disease, and inflammation (osteoarthritis and rheumatoid arthritis).

Abstract translation: 本发明一般涉及用于成纤维细胞生长因子（“FGF”）的组合物和方法。 更具体地，本发明涉及FGF-20的核苷酸多态性（SNP）及其片段，衍生物，变体，同系物和类似物，以及它们在伤口愈合中的用途，以及预防和/或治疗某些疾病 包括但不限于中风，放射病，粘膜炎，炎性肠病和炎症（骨关节炎和类风湿性关节炎）。

公开(公告)号：WO2004048512A3

公开(公告)日：2004-06-10

申请号：PCT/US2002/038371

申请日：2002-12-03

Applicant: CURAGEN CORPORATION ,  AGEE, Michele, L. ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CATTERTON, Elina ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GOULD-ROTHBERG, Bonnie, E. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  HALVORSEN, Yuan-Di ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLER, Charles, E. ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

Inventor： AGEE, Michele, L. ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CATTERTON, Elina ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GOULD-ROTHBERG, Bonnie, E. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  HALVORSEN, Yuan-Di ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLER, Charles, E. ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

IPC: C07K1/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0226826A3

公开(公告)日：2003-10-30

申请号：PCT/US0142336

申请日：2001-09-27

Applicant: CURAGEN CORP ,  GERLACH VALERIE L ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA ,  MILLET ISABELLE ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  PADIGARU MURALIDHARA ,  KEKUDA RAMESHA ,  SPYTEK KIMBERLY A ,  LEACH MARTIN D ,  SHIMKETS RICHARD A

Inventor： GERLACH VALERIE L ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA ,  MILLET ISABELLE ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  PADIGARU MURALIDHARA ,  KEKUDA RAMESHA ,  SPYTEK KIMBERLY A ,  LEACH MARTIN D ,  SHIMKETS RICHARD A

IPC: A61K38/00 ,  A61P3/10 ,  A61P9/10 ,  C07K14/47 ,  C12N15/12 ,  A61K31/713 ,  A61K38/17 ,  A61K39/395 ,  C07K16/18 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antiboides, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽和免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO0236632A3

公开(公告)日：2003-08-14

申请号：PCT/US0131744

申请日：2001-10-09

Applicant: CURAGEN CORP ,  ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  GROSSE WILLIAM M ,  LEPLEY DENISE M ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A

Inventor： ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  GROSSE WILLIAM M ,  LEPLEY DENISE M ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A

IPC: C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  G01N33/566 ,  G01N33/68 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C07K16/28 ,  G01N33/50 ,  G01N33/53

CPC classification number: G01N33/566 ,  A01K2217/05 ,  C07K14/705 ,  C07K14/723 ,  G01N33/6893

Abstract: The present invention provides novel isolated nucleic acid sequences having single nucleotide polymorphisms that encode olfactory receptor-like polypeptides and the polypeptides so encoded. Also provided are the antibodies that immunospecifically bind to these polypeptides or any derivative, variant, mutant or fragment of the polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供具有编码嗅觉受体样多肽和如此编码的多肽的单核苷酸多态性的新型分离的核酸序列。 还提供了免疫特异性结合这些多肽或多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：WO2003040330A2

公开(公告)日：2003-05-15

申请号：PCT/US2002/035536

申请日：2002-11-05

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BARON, Melanie ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HACKETT, Craig ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MAZUR, Ann ,  MCQUEENEY, Kelly ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  MISHRA, Vishnu, S. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  STARLING, Gary ,  SPYTEK, Kimberley, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ALVAREZ, Enrique ,  ANDERSON, David, W. ,  BARON, Melanie ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CHAPOVAL, Andrei ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HACKETT, Craig ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MAZUR, Ann ,  MCQUEENEY, Kelly ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  MISHRA, Vishnu, S. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  STARLING, Gary ,  SPYTEK, Kimberley, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12Q1/00

CPC classification number: C12N9/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

公开(公告)号：WO0234782A8

公开(公告)日：2003-03-27

申请号：PCT/US0146005

申请日：2001-10-23

Applicant: CURAGEN CORP ,  GERLACH VALERIE ,  MACDOUGALL JOHN R ,  MILLET ISABELLE ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  VERNAT CORINE A M ,  SHENOY SURESH ,  SPYTEK KIMBERLY ANN ,  MISHRA VISHNU ,  PADIGARU MURALIDHARA

Inventor： GERLACH VALERIE ,  MACDOUGALL JOHN R ,  MILLET ISABELLE ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  VERNAT CORINE A M ,  SHENOY SURESH ,  SPYTEK KIMBERLY ANN ,  MISHRA VISHNU ,  PADIGARU MURALIDHARA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C07K14/705

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003023002A9

公开(公告)日：2003-03-20

申请号：PCT/US2002/028539

申请日：2002-09-09

Applicant: CURAGEN CORPORATION ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

Inventor： SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

IPC: C07K1/00 ,  C07K4/00 ,  C07K17/00 ,  C12N15/00 ,  C12N15/09 ,  C12N5/63 ,  C12N15/70 ,  C12N15/74