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公开(公告)号:US20210079178A1
公开(公告)日:2021-03-18
申请号:US17105111
申请日:2020-11-25
Applicant: MicroOptx Inc.
Inventor: Tingrui Pan , Edward Aaron Cohen , Ben Bazor , Gaomai Yang
IPC: C08J5/12 , C08J7/18 , C08G81/00 , B81C3/00 , C08J7/16 , C08F290/14 , C08J7/12 , C09J5/00 , B81C1/00 , C08G81/02
Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.
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公开(公告)号:US20200297530A1
公开(公告)日:2020-09-24
申请号:US16360777
申请日:2019-03-21
Applicant: MicroOptx Inc.
Inventor: Edward Aaron Cohen , Daniel Charles Voce
IPC: A61F9/00 , A61F9/007 , A61K31/573 , A61K9/00
Abstract: An implantable ocular drug delivery system can include inserting an implantable device into an eye, where the device contains therapeutics intended to be released for local or systemic effects. In some implantable device embodiments, the device includes a microchannel intended to reduce intraocular pressure. In some implantable device embodiments, the device includes a microchannel intended to treat dry eye.
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公开(公告)号:US20190185629A1
公开(公告)日:2019-06-20
申请号:US16323481
申请日:2017-08-03
Applicant: MicroOptx Inc.
Inventor: Tingrui Pan , Edward Aaron Cohen , Ben Bazor , Gaomai Yang
CPC classification number: C08J5/128 , B81C1/00071 , B81C3/001 , B81C2201/034 , B81C2203/036 , C08F265/00 , C08F265/02 , C08F265/04 , C08F287/00 , C08F291/00 , C08F293/00 , C08G81/027 , C08J7/123 , C08J7/16 , C08J7/18 , C08J2367/02 , C08J2433/14 , C08J2433/16
Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.
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公开(公告)号:US20190175083A1
公开(公告)日:2019-06-13
申请号:US16209010
申请日:2018-12-04
Applicant: MicroOptx Inc.
Inventor: Edward Aaron Cohen , Roy Christian Martin
Abstract: Monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. In some implantable device embodiments, the device includes a polymer layer comprising a material that changes volume in response to varying glucose concentrations of the aqueous humor. A pressure sensor in the device can detect the changes in volume. In some implantable device embodiments, the device includes electrodes for determining the glucose concentration.
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公开(公告)号:AU2020240315A1
公开(公告)日:2021-10-14
申请号:AU2020240315
申请日:2020-03-20
Applicant: MICROOPTX INC
Inventor: COHEN EDWARD AARON , VOCE DANIEL CHARLES
Abstract: An implantable ocular drug delivery system can include inserting an implantable device into an eye, where the device contains therapeutics intended to be released for local or systemic effects. In some implantable device embodiments, the device includes a microchannel intended to reduce intraocular pressure. In some implantable device embodiments, the device includes a microchannel intended to treat dry eye.
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公开(公告)号:AU2015374033B2
公开(公告)日:2020-07-02
申请号:AU2015374033
申请日:2015-12-30
Applicant: MICROOPTX INC
Inventor: BROWN J DAVID
Abstract: Devices can be implanted in an eye to treat glaucoma. The devices described herein include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. By the strategic selection of particular materials of construction, and/or by controlling the configuration and size of the lumen, in some embodiments, the device is a filterless construct. In some embodiments, a filter is included. The glaucoma treatment devices as provided herein are designed to prevent bacterial ingress and to provide the required level of outflow resistance to achieve a desired intraocular pressure. Methods of treating glaucoma wherein the device is implanted in the sclera of an afflicted eye are also described.
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公开(公告)号:AU2017293767A1
公开(公告)日:2019-01-03
申请号:AU2017293767
申请日:2017-07-05
Applicant: MICROOPTX INC
Inventor: BROWN J DAVID , PULLING CHRISTOPHER CLARK , MARTIN ROY CHRISTIAN , COHEN EDWARD AARON
Abstract: Devices can be implanted in an eye to treat glaucoma and/or dry eye. The devices described herein include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. The body can include a radiused distal edge. A distal end portion of the body can be laterally flared. The body can include a mid-body portion that is laterally narrower than distal and proximal end portions of the body. Methods of treating glaucoma and/or dry eye, wherein the device is implanted in the sclera of an afflicted eye, are also described.
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公开(公告)号:AU2016353229A1
公开(公告)日:2018-05-31
申请号:AU2016353229
申请日:2016-11-11
Applicant: MICROOPTX INC
Inventor: MARTIN ROY CHRISTIAN , PULLING CHRISTOPHER CLARK , MARTIN CHRISTOPHER THOMAS , BROWN J DAVID
IPC: A61B3/12 , A61B5/1455 , A61B5/1459
Abstract: A method for monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. The method can optionally include optically detecting glucose concentration as a function of polarimetry and/or fluorescence. A system for monitoring glucose concentration can include devices described herein.
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公开(公告)号:AU2016331925A1
公开(公告)日:2018-04-26
申请号:AU2016331925
申请日:2016-09-30
Applicant: MICROOPTX INC
Inventor: BROWN J DAVID
Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.
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公开(公告)号:CA3029600A1
公开(公告)日:2018-01-11
申请号:CA3029600
申请日:2017-07-05
Applicant: MICROOPTX INC
Inventor: BROWN J DAVID , PULLING CHRISTOPHER CLARK , MARTIN ROY CHRISTIAN , COHEN EDWARD AARON
IPC: A61F9/007
Abstract: Devices can be implanted in an eye to treat glaucoma and/or dry eye. The devices described herein include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. The body can include a radiused distal edge. A distal end portion of the body can be laterally flared. The body can include a mid-body portion that is laterally narrower than distal and proximal end portions of the body. Methods of treating glaucoma and/or dry eye, wherein the device is implanted in the sclera of an afflicted eye, are also described.
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