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公开(公告)号:WO2016198667A1
公开(公告)日:2016-12-15
申请号:PCT/EP2016/063395
申请日:2016-06-10
Applicant: STAMFORD DEVICES LIMITED
Inventor: MACLOUGHLIN, Ronan , DUFFY, Conor , HOGAN, Brendan , KELLY, Patrick Martin
IPC: B05B17/00
CPC classification number: B05B17/0646
Abstract: A method for aerosolising a liquid comprises the steps of:- providing an aperture plate having at least 100 outlet holes per mm; delivering liquid to the aperture plate; and vibrating the aperture plate to produce an aerosol. The viscosity of the liquid is in the range of from 1 tol5 cP and the surface tension of the liquid is in the range of from 72 to 0.5 mN/m. The output rate of the generated aerosol is greater than 0.01 mL/min.
Abstract translation: 一种用于气溶胶化的方法包括以下步骤: - 提供孔径,每孔具有至少100个出口孔; 将液体输送到孔板; 并振动孔板产生气溶胶。 液体的粘度在1至15cP的范围内,液体的表面张力在72至0.5mN / m的范围内。 产生气溶胶的产出率大于0.01 mL / min。
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公开(公告)号:WO2016151029A1
公开(公告)日:2016-09-29
申请号:PCT/EP2016/056413
申请日:2016-03-23
Applicant: STAMFORD DEVICES LIMITED
Inventor: HYLAND, Kieran , COYE, Colga , KEATING, Fran
CPC classification number: A61M11/005 , A61M15/0085 , A61M16/0833 , A61M16/147 , A61M16/16 , B05B17/0646 , B05B17/0653 , B05B17/0676
Abstract: A liquid reservoir (100) of a nebulizer has a funnel portion (102) with ribs (103, 104) extending downwardly along a side wall towards a reservoir outlet (105). The ribs (103, 104) prevent the formation of air bubbles between the aperture plate and medication as any trapped air will be expelled along the geometry formed by the rib or groove and reservoir wall. Bubble formation is therefore prevented with only modification of the wall internal surface configuration of the reservoir.
Abstract translation: 喷雾器的液体储存器(100)具有漏斗部分(102),肋部(103,104)沿着侧壁朝着储存器出口(105)向下延伸。 肋(103,104)防止在孔板和药物之间形成气泡,因为任何被捕获的空气将沿着由肋或槽和储存器壁形成的几何形状排出。 因此,仅通过改变储存器的壁内表面结构来防止气泡形成。
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公开(公告)号:WO2013186031A3
公开(公告)日:2013-12-19
申请号:PCT/EP2013/060803
申请日:2013-05-24
Applicant: STAMFORD DEVICES LIMITED
Inventor: HOGAN, Brendan
Abstract: A photo-resist (21) is applied in a pattern of vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.
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公开(公告)号:WO2012046220A1
公开(公告)日:2012-04-12
申请号:PCT/IE2011/000054
申请日:2011-10-03
Applicant: STAMFORD DEVICES LIMITED , HOGAN, Brendan , HYLAND, Kieran , REDMOND, Anthony
Inventor: HOGAN, Brendan , HYLAND, Kieran , REDMOND, Anthony
CPC classification number: B05B17/0646 , A61M11/001 , A61M11/005 , A61M15/0085
Abstract: An aerosol generator (100) has a vibratable plate (1) with apertures therein and an annular piezo (2) which causes movement of the vibratable plate (1). An annular support member (3) supports the piezo (2) and the vibratable plate (1). A first electrical power conducting pin (10) engages directly with a first, top, surface of the piezo (2). A second electrical power conducting pin (11) indirectly conducts electrical power to a second surface of the piezo (2), by contacting an extension tab (103) of the support member (20), also on its top side. There is a film of cured epoxy adhesive on the tab (103), providing excellent gripping force between the pin (11) and the support (3). The aerosol generator (100) avoids need for soldered joints for electrical contact, and the pins are conveniently mounted parallel to each on the on the same lateral and top side of the piezo and support member. The pins may have multi-point tips (50) for particularly effective.
Abstract translation: 气溶胶发生器(100)具有其中具有孔的可振动板(1)和引起可振动板(1)移动的环形压电体(2)。 环形支撑构件(3)支撑压电体(2)和可振动板(1)。 第一电力导电销(10)与压电体(2)的第一顶表面直接接合。 第二电力导电销(11)通过在支撑构件(20)的顶侧上接触支撑构件(20)的延伸片(103)来间接地将电力传导到压电体(2)的第二表面。 在片(103)上存在固化的环氧树脂粘合剂膜,在销(11)和支撑(3)之间提供优异的夹持力。 气溶胶发生器(100)避免了用于电接触的焊接接头的需要,并且销被方便地平行地安装在压电和支撑构件的同一横向和顶侧上。 销可以具有特别有效的多点尖端(50)。
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公开(公告)号:WO2009118717A1
公开(公告)日:2009-10-01
申请号:PCT/IE2009/000010
申请日:2009-03-27
Applicant: STAMFORD DEVICES LIMITED , POWER, JOHN , SMITH, NIALL , DUFFY, CONOR , GIBBONS, KEITH , DIEMUNSCH, PIERRE AUGUSTE
Inventor: POWER, JOHN , SMITH, NIALL , DUFFY, CONOR , GIBBONS, KEITH , DIEMUNSCH, PIERRE AUGUSTE
CPC classification number: A61M13/003 , A61M11/005 , A61M15/0065 , A61M15/0066 , A61M16/0833 , A61M16/161 , A61M2205/7518 , B05B12/081 , B05B17/0646 , B05B17/0669
Abstract: Apparatus used in insufflation comprises an insufflator (12) for generating an insufflation gas such as carbon dioxide and an aerosol generator (2) for aerosolising a fluid and entraining the aerosol with the insufflation gas which is delivered during surgery. The aerosol generator (2) comprises a vibratable member (40) having a plurality of apertures extending between a first surface and a second surface. The fluid may comprise a therapeutic or prophylactic agent. A controller (3) is used to control the operation of the aerosol generator (2). The controller (3) controls operation, of the aerosol generator (2) responsive to the flow of insufflation' gas such as detected by a flow sensor (11). The pulse rate at a set frequency of. vibration of the vibratabie member (40) is controlled.
Abstract translation: 用于吹入的装置包括用于产生诸如二氧化碳的吹入气体的吹入器(12)和用于使流体气雾化并且在手术期间递送的吹入气体夹带气溶胶的气溶胶发生器(2)。 气溶胶发生器(2)包括具有在第一表面和第二表面之间延伸的多个孔的可振动构件(40)。 流体可以包含治疗剂或预防剂。 控制器(3)用于控制气溶胶发生器(2)的操作。 控制器(3)响应于诸如由流量传感器(11)检测的吹入气体的流动来控制气溶胶发生器(2)的操作。 脉冲频率在设定频率。 控制振动件(40)的振动。
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公开(公告)号:US12144923B2
公开(公告)日:2024-11-19
申请号:US17818549
申请日:2022-08-09
Applicant: Stamford Devices Limited
Inventor: Patrick Power
Abstract: An aerosol delivery system has a nebulizer and a humidifier providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch and a humidification branch.
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公开(公告)号:US11905615B2
公开(公告)日:2024-02-20
申请号:US17808432
申请日:2022-06-23
Applicant: Stamford Devices Limited
Inventor: Hong Xu
IPC: C25D7/00 , B41J2/16 , C25D5/02 , C25D5/10 , C25D1/00 , C25D5/00 , A61M11/00 , C25D5/54 , B05B17/00 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/34 , C25D5/48
CPC classification number: C25D7/00 , A61M11/005 , B05B17/0646 , B41J2/162 , B41J2/1625 , B41J2/1629 , B41J2/1631 , C25D1/003 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/022 , C25D5/10 , C25D5/34 , C25D5/48 , C25D5/54 , C25D5/611
Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
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公开(公告)号:US20230321368A1
公开(公告)日:2023-10-12
申请号:US17818549
申请日:2022-08-09
Applicant: Stamford Devices Limited
Inventor: Patrick POWER
CPC classification number: A61M11/02 , A61M11/00 , A61M16/024 , A61M16/16 , A61M16/161 , A61M11/06
Abstract: An aerosol delivery system has a nebulizer and a humidifier providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch and a humidification branch.
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公开(公告)号:US11759581B2
公开(公告)日:2023-09-19
申请号:US16857701
申请日:2020-04-24
Applicant: Stamford Devices Limited
Inventor: Patrick Joseph Power , Jimmy Eaton-Evans
CPC classification number: A61M11/02 , A61M15/0021 , A61M15/0085 , A61M16/06 , A61M16/208 , A61M11/003 , A61M2202/0208 , A61M2202/04
Abstract: A system for delivery of aerosol therapy includes a housing defining a chamber. The housing has a base, a top and a main body extending therebetween. An ambient air inlet is adjacent the base and is normally closed by an inlet valve. The housing has a patient port. Exhaled air is exhausted through valves in a mouthpiece or a face mask to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.
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公开(公告)号:US11672939B2
公开(公告)日:2023-06-13
申请号:US16749024
申请日:2020-01-22
Applicant: Stamford Devices Limited
Inventor: John Sylvester Power , James B. Fink , Conor Paul Duffy , Trevor Stephen Fahy
IPC: A61M16/00 , A61M16/14 , A61M15/00 , A61M11/00 , A61M16/06 , A61M16/08 , A61M16/16 , B05B12/08 , B05B17/00 , B05B17/06
CPC classification number: A61M16/14 , A61M11/002 , A61M11/003 , A61M11/005 , A61M15/0085 , A61M16/0057 , A61M16/0666 , A61M16/0672 , A61M16/0833 , A61M16/0875 , A61M16/147 , A61M16/16 , A61M16/0808 , A61M2202/0208 , A61M2206/14 , B05B12/081 , B05B17/0646 , B05B17/0669
Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.
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