公开(公告)号：WO2011094073A4

公开(公告)日：2012-01-19

申请号：PCT/US2011021227

申请日：2011-01-14

Applicant: MEDTRONIC INC ,  URBAN JON F ,  SHARMA VINOD ,  STEWART MARK T

Inventor： URBAN JON F ,  SHARMA VINOD ,  STEWART MARK T

IPC: A61N1/05 ,  A61B17/00 ,  A61M25/00

CPC classification number: A61N1/0575 ,  A61B5/042 ,  A61B5/6848 ,  A61B5/6852 ,  A61B2017/00053 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0091

Abstract: A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.

Abstract translation: 系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。 该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

公开(公告)号：WO2011106240A1

公开(公告)日：2011-09-01

申请号：PCT/US2011/025309

申请日：2011-02-17

Applicant: MEDTRONIC INC. ,  STEWART, Mark T. ,  FRANCISCHELLI, David E.

Inventor： STEWART, Mark T. ,  FRANCISCHELLI, David E.

IPC: A61B18/14

CPC classification number: A61N7/02 ,  A61B8/485 ,  A61B8/5223 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61N2007/0065 ,  A61N2007/0095 ,  A61N2007/027

Abstract: Device, system and method for evaluating the effectiveness of tissue ablations of a heart of a patient. The tissue is clamped between a pair of opposing jaws. A portion of the tissue is ablated at a first generally linear position on the tissue by applying ablative energy to two of a plurality of elongate electrodes, each of the two of the plurality of elongate electrodes being coupled in opposing relationship to each other and the pair of opposing jaws, respectively. An effectiveness of the ablation is sensed at a second generally linear position on the tissue with at least one of the plurality of elongate electrodes positioned on one of the pair of opposing jaws. The second linear position on the tissue is laterally distal to the first linear position on the tissue with respect to the atrium of the heart.

Abstract translation: 用于评估患者心脏组织消融有效性的装置，系统和方法。 将组织夹在一对相对的夹爪之间。 通过向多个细长电极中的两个施加烧蚀能量，组织的一部分在组织上的第一大致线性位置被消融，多个细长电极中的每一个彼此相对地相互耦合，并且该对 的对颚分别。 在组织上的第二大致直线位置处感测消融的有效性，其中多个细长电极中的至少一个位于一对相对的夹爪中的一个上。 组织上的第二线性位置相对于心脏的心房横向远离组织上的第一线性位置。

公开(公告)号：WO2011094073A2

公开(公告)日：2011-08-04

申请号：PCT/US2011/021227

申请日：2011-01-14

Applicant: MEDTRONIC, INC. ,  URBAN, Jon F. ,  SHARMA, Vinod ,  STEWART, Mark T.

Inventor： URBAN, Jon F. ,  SHARMA, Vinod ,  STEWART, Mark T.

IPC: A61N1/05

CPC classification number: A61N1/0575 ,  A61B5/042 ,  A61B5/6848 ,  A61B5/6852 ,  A61B2017/00053 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0091

Abstract: A system and associated method measure monophasic action potential signals for identifying a targeted tissue location and delivering a therapy to the targeted tissue location. The system includes a hollow needle having a sharpened distal tip, a first electrode at the distal tip and a fluid delivery lumen extending through the needle from a proximal needle end to an opening in the sharpened distal tip.

Abstract translation: 系统和相关联的方法测量用于识别目标组织位置并将治疗递送到目标组织位置的单相动作电位信号。 该系统包括具有锐化的远端尖端的中空针头，远侧末端处的第一电极和从近端针端延伸穿过尖锐远端的开口的流体输送腔。

公开(公告)号：WO2011089396A2

公开(公告)日：2011-07-28

申请号：PCT/GB2011/000079

申请日：2011-01-21

Applicant: ST GEORGE'S HOSPITAL MEDICAL SCHOOL ,  THE UNIVERSITY OF MANCHESTER ,  ROBINSON, Clive ,  ZHANG, Jihui ,  GARROD, David, Ronald ,  PERRIOR, Trevor, Robert ,  NEWTON, Gary, Karl ,  JENKINS, Kerry ,  BEEVERS, Rebekah, Elisabeth ,  KIMBERLEY, Meriel, Ruth ,  STEWART, Mark, Richard

Inventor： ROBINSON, Clive ,  ZHANG, Jihui ,  GARROD, David, Ronald ,  PERRIOR, Trevor, Robert ,  NEWTON, Gary, Karl ,  JENKINS, Kerry ,  BEEVERS, Rebekah, Elisabeth ,  KIMBERLEY, Meriel, Ruth ,  STEWART, Mark, Richard

IPC: C07K5/06 ,  C07K5/08 ,  A61P37/08 ,  A61P37/06

CPC classification number: C07K5/0202 ,  A01N37/46 ,  A01N43/16 ,  A01N43/30 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/42 ,  A01N43/48 ,  A01N43/60 ,  A01N43/72 ,  A01N43/84 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K5/06008 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/0827

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.

Abstract translation: 本发明一般涉及治疗化合物领域，更具体地涉及式（X）的某些丙酮酰胺化合物（为了方便起见，统称为“PVA化合物”），其特别是抑制尘螨组 1肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由 尘螨1组肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎 特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

公开(公告)号：WO2011014602A1

公开(公告)日：2011-02-03

申请号：PCT/US2010/043623

申请日：2010-07-29

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  LAU, Michael ,  WERNETH, Randell ,  CORVI, Timothy, J. ,  BHOLA, Sumita ,  STEWART, Mark, T. ,  HAÏSSAGUERRE, Michel

Inventor： LAU, Michael ,  WERNETH, Randell ,  CORVI, Timothy, J. ,  BHOLA, Sumita ,  STEWART, Mark, T. ,  HAÏSSAGUERRE, Michel

IPC: A61N1/05 ,  A61B5/042 ,  A61B18/12 ,  A61B18/14

CPC classification number: A61N1/056 ,  A61B5/0422 ,  A61B5/6852 ,  A61B5/6856 ,  A61B18/12 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/0066 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2562/0215

Abstract: Catheters and methods for obtaining monophasic action potential ("MAP") electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.

Abstract translation: 用于获得单相动作电位（“MAP”）电描记图的导管和方法包括限定纵向轴线的柔性导管主体，以及固定到导管主体远端的远端组件，其限定远端尖端。 远端组件具有至少三个MAP记录电极和用于确定参考电位的至少一个参考电极。 记录电极各自在至少三个不同的径向方向上与纵向轴线径向距离，限定基本上具有径向对称性的记录几何形状。 参考电极是与记录几何形状的纵向距离。 可选功能包括可导向的导管轴，一个或多个射频消融电极和专用起搏电极。 不同的可能实施例包括具有固定空间布置的记录电极的圆顶壳体和在至少三个柔性环形元件上具有电极阵列的远端环组件。

公开(公告)号：WO2011002699A2

公开(公告)日：2011-01-06

申请号：PCT/US2010/040151

申请日：2010-06-28

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  STEWART, Mark ,  CLARK, Howard ,  COFFEY, Duncan ,  LUO, Lin ,  SCHWEIZER, Albert E. Jr.

Inventor： STEWART, Mark ,  CLARK, Howard ,  COFFEY, Duncan ,  LUO, Lin ,  SCHWEIZER, Albert E. Jr.

IPC: C07C41/09

CPC classification number: C07C41/09 ,  C07C1/24 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/12 ,  C07C2523/28 ,  C07C2523/30 ,  C07C2527/167 ,  C07C11/02 ,  C07C11/04 ,  C07C43/06

Abstract: A process to prepare an olefin from its corresponding alcohol is improved by reacting, under reaction conditions including a first temperature, an aliphatic alcohol and, optionally, diluent water, to form a reaction product including at least a dialkyl ether. The product is then reacted again, under higher temperature to complete the dehydration of the dialkyl ether to the desired olefin. This process is particularly suitable to prepare ethene from ethyl alcohol. The stepped temperature scheme serves to reduce the formation of byproduct aldehydes, which in turn reduces coke formation, fouling, and the need to handle large amounts of water, thereby lowering energy and capital costs.

Abstract translation: 在相应的醇中制备烯烃的方法通过在包括第一温度，脂族醇和任选稀释剂水的反应条件下反应以形成反应产物，所述反应产物包含至少一种 二烷基醚。 然后在较高的温度下使产物再次反应以完成二烷基醚脱水成所需的烯烃。 该方法特别适用于从乙醇制备乙烯。 阶梯式温度控制方案可减少副产品醛的形成，从而减少焦炭的形成，结垢和处理大量水的需求，从而降低能源和资金成本。

公开(公告)号：WO2010004317A1

公开(公告)日：2010-01-14

申请号：PCT/GB2009/050786

申请日：2009-07-03

Applicant: TAILWIND SOLUTIONS LIMITED ,  KNOX, Garry ,  STEWART, Mark

Inventor： KNOX, Garry ,  STEWART, Mark

IPC: G07F19/00 ,  G07G1/00 ,  G06Q20/00 ,  G06K7/00

CPC classification number: G06Q20/20 ,  G06Q40/02 ,  G07F7/0873

Abstract: A PIN-entry device (PED) stand (27) includes a data interface whereby the stand may be connected to an EFT card payment system (10) for transmitting and/or receiving data to and/or from the EFT card payment system independently of a PED (18) mounted on the stand. The stand further includes any one or more of the following, in communication with the data interface: a data input device such as a contactless card reader ( 36) or a biometric devicefor receiving information for processing a card transaction and/or for management of the payment system; at least one further data interface whereby the stand may be connected to a peripheral device; a secure memory device for storing a secret key for use in an authentication system. Software of the EFT card payment system drivesa display (24) of a PED (18) installed on the PED (27) stand and connected to the payment system (10) in order to display information relating to functions associated with the data input device, further data interface and/or peripheral device connected thereto, and/or secure memory device of the PED stand.

Abstract translation: PIN输入设备（PED）支架（27）包括一个数据接口，借此支架可以连接到EFT卡支付系统（10），用于向EFT卡支付系统发送和/或从EFT卡支付系统接收数据， 安装在支架上的PED（18）。 支架还包括与数据接口通信的任何一个或多个以下内容：诸如非接触式读卡器（36）的数据输入设备或用于接收处理卡交易的信息和/或用于管理卡片交易的信息的生物测定设备 支付系统; 至少一个另外的数据接口，其中支架可以连接到外围设备; 用于存储在认证系统中使用的秘密密钥的安全存储器装置。 EFT卡支付系统的软件驱动安装在PED（27）上的PED（18）的显示器（24），并连接到支付系统（10），以便显示与数据输入设备相关的功能相关的信息， 连接到其上的另外的数据接口和/或外围设备，和/或PED支架的安全存储器设备。

公开(公告)号：WO2009140359A3

公开(公告)日：2009-11-19

申请号：PCT/US2009/043751

申请日：2009-05-13

Applicant: MEDTRONIC, INC. ,  STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  HONG, Jinback

Inventor： STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  HONG, Jinback

IPC: A61B18/14 ,  A61B18/00 ,  A61N1/37

Abstract: Device, system and method for ablating tissue of a heart of a patient. The tissue is clamped between a pair of opposing jaws. A portion of the tissue is ablated at a first generally linear position on the tissue by applying ablative energy to two of a plurality of elongate electrodes, each of the two of the plurality of elongate electrodes being coupled in opposing relationship to each other and the pair of opposing jaws, respectively. An effectiveness of the ablation is sensed at a second generally linear position on the tissue with at least one of the plurality of elongate electrodes positioned on one of the pair of opposing jaws. The second linear position on the tissue is laterally distal to the first linear position on the tissue with respect to the atrium of the heart.

公开(公告)号：WO2005113068A1

公开(公告)日：2005-12-01

申请号：PCT/US2005/016860

申请日：2005-05-13

Applicant: MEDTRONIC, INC. ,  STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  SKARDA, James, R. ,  KEOGH, James, R. ,  HISSONG, James, B.

Inventor： STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  SKARDA, James, R. ,  KEOGH, James, R. ,  HISSONG, James, B.

IPC: A61N7/02

CPC classification number: A61N7/022 ,  A61B8/4281 ,  A61B17/2202 ,  A61B18/1492 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00363 ,  A61B2018/00839 ,  A61B2018/1472

Abstract: A method of thermal ablation using high intensity focused ultrasound energy includes the steps of positioning one or more ultrasound emitting members within a patient, emitting ultrasound energy from the one or more ultrasound emitting members, focusing the ultrasound energy, ablating with the focused ultrasound energy to form an ablated tissue area and removing the ultrasound emitting member.

Abstract translation: 使用高强度聚焦超声能量的热消融的方法包括将一个或多个超声发射部件定位在患者体内的步骤，从一个或多个超声发射部件发射超声能量，将超声能量聚焦，用聚焦的超声能量消融到 形成消融的组织区域并移除超声发射构件。

公开(公告)号：WO2005077451A1

公开(公告)日：2005-08-25

申请号：PCT/US2005/002802

申请日：2005-02-02

Applicant: MEDTRONIC, INC. ,  WAHLSTROM, Dale, A. ,  ERLEBACHER, Jay, A. ,  SOMMER, John, L. ,  STEWART, Mark, T.

Inventor： WAHLSTROM, Dale, A. ,  ERLEBACHER, Jay, A. ,  SOMMER, John, L. ,  STEWART, Mark, T.

IPC: A61N1/05

CPC classification number: A61N1/057 ,  A61N2001/0585

Abstract: Novel retention means (380) extending along a length of an elongate body of a medical device include a plurality of projections (385) adapted to interfere with a wall of a generally tubular vessel to retain the body within the vessel.

Abstract translation: 沿着医疗装置的细长主体的长度延伸的小型保持装置（380）包括多个突起（385），其适于干扰大致管状容器的壁以将身体保持在容器内。