公开(公告)号：WO2012106100A3

公开(公告)日：2012-09-20

申请号：PCT/US2012021478

申请日：2012-01-17

Applicant: MEDTRONIC ABLATION FRONTIERS ,  SHERMAN MARSHALL L ,  CONDIE CATHERINE R ,  STEWART MARK T

Inventor： SHERMAN MARSHALL L ,  CONDIE CATHERINE R ,  STEWART MARK T

IPC: A61B18/12 ,  A61B18/00

CPC classification number: A61B5/0531 ,  A61B5/0536 ,  A61B5/4848 ,  A61B5/7246 ,  A61B18/02 ,  A61B18/12 ,  A61B18/1492 ,  A61B2017/00128 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00666 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/0212

Abstract: A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; the medical device measuring a first impedance magnitude at a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.

Abstract translation: 一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 所述医疗设备用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用所述医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

公开(公告)号：WO2011136867A1

公开(公告)日：2011-11-03

申请号：PCT/US2011/026007

申请日：2011-02-24

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  WERNETH, Randell L. ,  SHERMAN, Marshall L. ,  STEWART, Mark T. ,  FLAHERTY, J. Christopher

Inventor： WERNETH, Randell L. ,  SHERMAN, Marshall L. ,  STEWART, Mark T. ,  FLAHERTY, J. Christopher

IPC: A61B5/06 ,  A61B18/00 ,  A61B5/053 ,  A61B19/00 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/08 ,  A61B5/103

CPC classification number: A61B18/1492 ,  A61B5/01 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/06 ,  A61B5/063 ,  A61B5/08 ,  A61B5/103 ,  A61B5/6885 ,  A61B5/7207 ,  A61B5/743 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/24 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0262 ,  A61B2034/2046 ,  A61B2090/065 ,  G06F19/00

Abstract: A medical method is provided, including a medical device having a distal assembly including at least one electrode and at least one treatment element, the medical device generating information regarding at least one of a physiological measurement and an operational parameter of the medical device; a plurality of surface electrodes affixable to a skin of the patient, wherein the surface electrodes are in electrical communication with the distal assembly to obtain position information of the medical device; and a processor pairing the position information and the at least one of a physiological measurement and an operational parameter of the medical device.

Abstract translation: 提供了一种医疗方法，包括具有包括至少一个电极和至少一个治疗元件的远端组件的医疗装置，所述医疗装置产生关于所述医疗装置的生理测量和操作参数中的至少一个的信息; 多个表面电极可固定在患者皮肤上，其中表面电极与远端组件电连通以获得医疗装置的位置信息; 以及将所述位置信息和所述医疗装置的生理测量和操作参数中的至少一个配对的处理器。

公开(公告)号：WO2011041123A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/049066

申请日：2010-09-16

Applicant: MEDTRONIC INC. ,  KEOGH, James, R. ,  RYAN, Timothy, R. ,  EBERHARDT, Carol, E. ,  STEWART, Mark, T. ,  SKARDA, James, R. ,  LASKE, Timothy, G. ,  HILL, Alexander, J. ,  LEMMON, Jack, D. ,  FRANCISCHELLI, David, E.

Inventor： KEOGH, James, R. ,  RYAN, Timothy, R. ,  EBERHARDT, Carol, E. ,  STEWART, Mark, T. ,  SKARDA, James, R. ,  LASKE, Timothy, G. ,  HILL, Alexander, J. ,  LEMMON, Jack, D. ,  FRANCISCHELLI, David, E.

IPC: A61N7/02 ,  A61B19/00 ,  A61B17/00 ,  A61B18/14 ,  A61N7/00

CPC classification number: A61F2/2496 ,  A61B5/0044 ,  A61B5/1076 ,  A61B5/6853 ,  A61B8/445 ,  A61B18/1442 ,  A61B34/20 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/00243 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2090/378 ,  A61B2090/397 ,  A61F2/2433 ,  A61F2210/009 ,  A61F2250/0096 ,  A61N7/02

公开(公告)号：WO2010014480A1

公开(公告)日：2010-02-04

申请号：PCT/US2009/051470

申请日：2009-07-23

Applicant: MEDTRONIC, INC. ,  BONNER, Matthew, D. ,  FRANCISCHELLI, David, E. ,  STEWART, Mark, T. ,  CHEEK, Daniel, S. ,  HONG, Jinback ,  NIKOLSKI, Vladimir, P.

Inventor： BONNER, Matthew, D. ,  FRANCISCHELLI, David, E. ,  STEWART, Mark, T. ,  CHEEK, Daniel, S. ,  HONG, Jinback ,  NIKOLSKI, Vladimir, P.

IPC: A61B18/00

CPC classification number: A61B18/1442 ,  A61B18/1492 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/122 ,  A61B2218/002 ,  A61B2218/007

Abstract: Cardiac electroporation ablation systems in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.

Abstract translation: 心脏电穿孔消融系统，其中输送脉冲的高电压能量以诱导心脏组织细胞的电穿孔，随后细胞破裂。 在一些实施方案中，所递送的能量是双相的，循环时间不超过500微秒。

公开(公告)号：WO2009108464A1

公开(公告)日：2009-09-03

申请号：PCT/US2009/032952

申请日：2009-02-03

Applicant: MEDTRONIC , INC. ,  CLAGUE, Cynthia, T. ,  STEWART, Mark, T. ,  GREEN, Michael, M. ,  ROTHSTEIN, Paul, T. ,  JELICH, Damian, A. ,  NAYAK, Asha, S. ,  TORRIANNI, Mark, W. ,  COPPIN, Chris, M. ,  HUYNH, Rany ,  MEYER, Eric, A. ,  LIDDICOAT, John, R. ,  LASKE, Timothy, G.

Inventor： CLAGUE, Cynthia, T. ,  STEWART, Mark, T. ,  GREEN, Michael, M. ,  ROTHSTEIN, Paul, T. ,  JELICH, Damian, A. ,  NAYAK, Asha, S. ,  TORRIANNI, Mark, W. ,  COPPIN, Chris, M. ,  HUYNH, Rany ,  MEYER, Eric, A. ,  LIDDICOAT, John, R. ,  LASKE, Timothy, G.

IPC: A61B17/00 ,  A61B17/08 ,  A61B17/064

CPC classification number: A61B17/0057 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/081

Abstract: A surgical fastener clip (20) for proximating tissue, the clip providing an undeflected state in which the clip comprises a center portion (22), a, first leg (24), and a second leg (26). The center portion has a perimeter (28) defining a circle-like shape. The legs (24,26) project outwardly relative to the perimeter from a point of departure to a tip (30,32). Extension of each of the legs relative to the perimeter defines an identical wind direction that is either clockwise or counterclockwise. The clip optionally includes a linear cross-member (60) extending across the perimeter (28). The surgical clip can be formed by a wire (70) that is partially wound onto itself in a spiral-like fashion, with the center portion (22) and the legs (24,26) being co-planar in the undeflected state. During use, the clip is rotated, drawing tissue into the center portion. Systems incorporating the clip are also provided.

Abstract translation: 一种用于接近组织的手术紧固夹（20），所述夹提供未偏转状态，其中夹具包括中心部分（22），第一腿部（24）和第二腿部（26）。 中心部分具有限定圆形形状的周边（28）。 腿部（24,26）从出发点向尖端（30,32）相对于周边向外突出。 每个腿相对于周边的延伸限定了顺时针或逆时针方向相同的风向。 夹子可选地包括横跨周边（28）延伸的线性横向构件（60）。 手术夹可以由线（70）形成，线（70）以螺旋状的方式部分地缠绕在自身上，中心部分（22）和腿部（24,26）在未偏转状态下是共面的。 在使用过程中，夹子旋转，将纸巾拉入中心部分。 还提供了结合夹子的系统。

公开(公告)号：WO2007140331A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/069789

申请日：2007-05-25

Applicant: MEDTRONIC, INC. ,  STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  KEOGH, James, R. ,  HISSONG, James, B. ,  SKARDA, James, R. ,  LEE, Hotaik ,  SMITH, Nadine, B.

Inventor： STEWART, Mark, T. ,  FRANCISCHELLI, David, E. ,  KEOGH, James, R. ,  HISSONG, James, B. ,  SKARDA, James, R. ,  LEE, Hotaik ,  SMITH, Nadine, B.

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B8/4281 ,  A61B34/20 ,  A61B2017/320076 ,  A61B2017/320078 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract translation: 公开了一种用于消融组织的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪患者内的消融部件的位置的同时引导患者内的消融部件，定位消融 成员在消融组织的期望位置，从烧蚀构件发出消融能量以形成消融的组织区域，并从患者身上移除消融部件。

公开(公告)号：WO2004100813A3

公开(公告)日：2005-01-06

申请号：PCT/US2004014224

申请日：2004-05-07

Applicant: MEDTRONIC INC ,  STEWART MARK T ,  FIEDLER GARY R ,  SANDSTONE JEFFREY D

Inventor： STEWART MARK T ,  FIEDLER GARY R ,  SANDSTONE JEFFREY D

IPC: A61B10/00 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B10/0233 ,  A61B2018/00011 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2218/002

Abstract: According to the present invention, a catheter having at least one multi-purpose lumen formed through the catheter terminates proximal a relatively complex-shaped distal portion thereof. In one form of this embodiment, the relatively complex-shaped distal portion comprises a looped portion having diagnostic- and/or ablation-type electrodes coupled thereto and an elongated diameter-adjusting member coupled proximal the distal end of the looped portion. The multi-purpose lumen may be used to alternately accommodate a variety of dedicated materials; such as, (i) a guide wire for initial deployment or later repositioning of the catheter, (ii) a volume or flow of a contrast media and the like, (iii) a deployable hollow needle or tube and the like used to biopsy adjacent tissue or dispense a therapeutic agent into a volume of tissue, and (iv) a cooling fluid, such as saline solution and the like dispensed at least during therapeutic tissue ablation procedures.

Abstract translation: 根据本发明，具有通过导管形成的至少一个多用途腔的导管终止于其相对复杂形状的远端部分的近端。 在该实施例的一种形式中，相对复杂形状的远侧部分包括具有耦合到其上的诊断和/或消融型电极的环形部分和在环形部分的远端附近耦合的细长直径调节构件。 多用途腔可用于交替容纳各种专用材料; 例如，（i）用于初始部署或稍后重新定位导管的导丝，（ii）造影剂等的体积或流动，（iii）用于活检相邻的可展开的空心针或管等 组织或将治疗剂分配到一定体积的组织中，和（iv）至少在治疗性组织消融过程期间分配的冷却液，例如盐水溶液等。

公开(公告)号：WO2013019385A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/046617

申请日：2012-07-13

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  STEWART, Mark T. ,  HONECK, Jordon D.

Inventor： STEWART, Mark T. ,  HONECK, Jordon D.

IPC: A61B18/14 ,  A61N1/32

CPC classification number: A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00613 ,  A61B2018/1435 ,  A61N1/327

Abstract: A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.

Abstract translation: 一种医疗系统，包括具有多个可展开臂的医疗装置，以及至少一个所述多个臂中的至少一个上的至少一个电极; 以及与该医疗装置通信的电信号发生器，该电信号发生器被编程为将脉冲能量传送到医疗装置，足以引起不可逆电穿孔消融。

公开(公告)号：WO2012121882A1

公开(公告)日：2012-09-13

申请号：PCT/US2012/026042

申请日：2012-02-22

Applicant: MEDTRONIC ABLATION FRONTIERS LLC ,  WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

Inventor： WERNETH, Randell L. ,  HOCINI, Meleze ,  STEWART, Mark T. ,  WITTENBERGER, Dan ,  CORVI, Timothy J. ,  LAU, Michael ,  SHARMA, Vinod

IPC: A61B5/042 ,  A61N1/05 ,  A61B18/14

CPC classification number: A61B5/0422 ,  A61B18/1492 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

Abstract: A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.

Abstract translation: 一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。 控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

公开(公告)号：WO2007140331A3

公开(公告)日：2008-01-17

申请号：PCT/US2007069789

申请日：2007-05-25

Applicant: MEDTRONIC INC ,  STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

Inventor： STEWART MARK T ,  FRANCISCHELLI DAVID E ,  KEOGH JAMES R ,  HISSONG JAMES B ,  SKARDA JAMES R ,  LEE HOTAIK ,  SMITH NADINE B

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B8/4281 ,  A61B34/20 ,  A61B2017/320076 ,  A61B2017/320078 ,  A61B2018/00291 ,  A61B2034/2051 ,  A61B2090/378 ,  A61B2090/3782 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A device and method for ablating tissue is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding an ablating member within the patient while tracking the position of the ablating member in the patient, positioning the ablating member in a desired position to ablate tissue, emitting ablating energy from the ablating member to form an ablated tissue area and removing the ablating member from the patient.

Abstract translation: 公开了一种用于消融组织的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪患者内的消融部件的位置的同时引导患者内的消融部件，定位消融 成员在消融组织的期望位置，从烧蚀构件发出消融能量以形成消融的组织区域，并从患者身上移除消融部件。