公开(公告)号：WO0158951A3

公开(公告)日：2002-02-14

申请号：PCT/EP0101457

申请日：2001-02-09

Applicant: STICHTING TECH WETENSCHAPP ,  SMIT AUGUST BENJAMIN ,  SIXMA TITIA KAREN

Inventor： SMIT AUGUST BENJAMIN ,  SIXMA TITIA KAREN

IPC: G01N33/50 ,  A61K31/14 ,  A61K31/197 ,  A61K31/221 ,  A61K31/27 ,  A61K31/4045 ,  A61K31/4439 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/34 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

CPC classification number: C07K14/70571 ,  C07K2319/00

Abstract: Provided are water-soluble ligand-binding proteins derived from molluscs and analogs of ligand-gated ion channels, crystals thereof and their use for screening ligands of ligand-gated ion channels. In particular, water-soluble ligand-binding proteins are provided that are capable of forming multimers and are amenable to crystallization. The crystal structure of one of these proteins, an acetylcholine binding protein (AChBP) is provided, which can be used to generate 3D models of the extracellular ligand-binding domain of ligand-gated ion channels and thus for screening of drugs that act on these ion channels. Furthermore, chimeric proteins are provided that are capable of binding a ligand of a ligand-gated receptor, and comprising at least the amino acids of the AChBP determining solubility of the AChBP, in the same positions as in the AChBP, and furthermore comprising amino acids determining binding to said ligand.

Abstract translation: 提供衍生自软体动物和配体门控离子通道类似物的水溶性配体结合蛋白，其晶体及其用于筛选配体门控离子通道的配体。 特别地，提供能够形成多聚体并且适于结晶的水溶性配体结合蛋白。 提供这些蛋白质之一的晶体结构，即乙酰胆碱结合蛋白（AChBP），其可用于产生配体门控离子通道的细胞外配体结合结构域的3D模型，因此用于筛选作用于这些蛋白质的药物 离子通道。 此外，提供嵌合蛋白，其能够结合配体门控受体的配体，并且至少包含决定AChBP的溶解度的AChBP的氨基酸与AChBP相同的位置，并且还包含氨基酸 确定与所述配体的结合。

公开(公告)号：WO0032629A3

公开(公告)日：2000-08-17

申请号：PCT/NL9900732

申请日：1999-12-01

Applicant: STICHTING TECH WETENSCHAPP ,  NIEUW AMERONGEN ARIE VAN ,  VEERMAN ENGELMUNDUS CORNELIS I ,  T HOF WILLEM VAN ,  NIBBERING PETER HENDRICUS

Inventor： VAN NIEUW AMERONGEN ARIE ,  VEERMAN ENGELMUNDUS CORNELIS I ,  VAN T HOF WILLEM ,  NIBBERING PETER HENDRICUS

IPC: A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  A61K38/10 ,  A61K38/17 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K14/4723

Abstract: The invention relates to peptides for use as antiviral agent, consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids. The invention further relates to oligomers of these peptides consisting of at least two such peptides which are coupled to each other, optionally via a spacer, for use as antiviral agent, in addition to the use of the peptides and/or oligomers for the manufacture of a medicine for treating viral infections.

Abstract translation: 本发明涉及用作抗病毒剂的肽，其由包含10至25个氨基酸的结构域的氨基酸链组成，其中该域的一半的大部分氨基酸是带正电荷的氨基酸，并且多数 的另一半结构域的氨基酸是不带电荷的氨基酸。 本发明还涉及由至少两种这样的肽组成的这些肽的寡聚体，除了使用肽和/或低聚物以外，还可以任选经由间隔物彼此偶联，用作抗病毒剂。 用于治疗病毒感染的药物。

公开(公告)号：WO2014098593A1

公开(公告)日：2014-06-26

申请号：PCT/NL2013050925

申请日：2013-12-19

Applicant: STICHTING TECH WETENSCHAPP ,  STICHTING VU VUMC ,  UNIV GRONINGEN ,  GRONINGEN ACAD ZIEKENHUIS

Inventor： RAAPHORST RENSKE ,  LUURTSEMA GERT ,  WINDHORST ALBERT DIRK ,  LAMMERTSMA ADRIAAN

IPC: A61K51/04 ,  A61K31/277 ,  C07B59/00

CPC classification number: A61K31/277 ,  A61K51/04 ,  C07B59/001

Abstract: The invention is directed to a compound, a salt or a solvate thereof according to (I) wherein R1 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group, R2, R3, R4 and R5 are eacn independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein R1 is a methyl group, and R3 is a R3 is a fluoroalkyl group or a [18F]fluoroalkyl group, R2, R4 and R5 are each independently a methyl, [3H]methyl, fluoroalkyl or [18F]fluoroalkyl group, and R6 is a (R)-cyano group or a (S)-cyano group; or wherein if R1 is hydrogen, at least one of R2, R3, R4 is an optionally branched fluoroalkyl group or [18F]fluoroalkyl group.

Abstract translation: 本发明涉及根据（I）的化合物，其盐或溶剂合物，其中R 1是任选支链的氟代烷基或[18 F]氟代烷基，R 2，R 3，R 4和R 5独立地是甲基，[3 H] 甲基，氟代烷基或[18 F]氟烷基，R 6为（R） - 氰基或（S） - 氰基; 或其中R 1为甲基，R 3为R 3为氟烷基或[18 F]氟代烷基，R 2，R 4和R 5各自独立地为甲基，[3 H]甲基，氟代烷基或[18 F]氟代烷基，和 R6是（R） - 氰基或（S） - 氰基; 或其中如果R 1是氢，则R 2，R 3，R 4中的至少一个是任选支链的氟代烷基或[18 F]氟代烷基。

公开(公告)号：WO2008018792A3

公开(公告)日：2008-04-03

申请号：PCT/NL2007050396

申请日：2007-08-07

Applicant: APPLIED NANOSYSTEMS BV ,  STICHTING TECH WETENSCHAPP ,  HAAS MARIJKE ,  KLUSKENS LEONARDUS DOROTHEA ,  KUIPERS ANNEKE ,  RINK RICK ,  NELEMANS SIEGER ADRIAAN ,  MOLL GERT NIKOLAAS

Inventor： HAAS MARIJKE ,  KLUSKENS LEONARDUS DOROTHEA ,  KUIPERS ANNEKE ,  RINK RICK ,  NELEMANS SIEGER ADRIAAN ,  MOLL GERT NIKOLAAS

IPC: C07K7/14 ,  A61K38/08 ,  A61L31/16

CPC classification number: C07K7/14 ,  A61L31/16 ,  A61L2300/25

Abstract: The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(l-8) agonistic or antagonistic activity and to cyclised Ang(l-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr 4 and Pro 7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.

Abstract translation: 本发明涉及血管紧张肽类似物，特别是涉及具有Ang（1-8）激动或拮抗活性的环化类似物和具有激动或拮抗活性的环化Ang（1-7）类似物，并且与其线性对应物相比显示出改善的蛋白水解抗性。 提供了一种环状血管紧张素肽类似物，其在对应于天然存在的血管紧张素中的Tyr 4和Pro 7的氨基酸之间包含硫醚 - 桥键。 还提供了类似物在治疗中的用途，例如高血压。

公开(公告)号：WO2008026915A2

公开(公告)日：2008-03-06

申请号：PCT/NL2007000211

申请日：2007-08-29

Applicant: STICHTING TECH WETENSCHAPP ,  SMIJS GEERTRUIDA MARIA THERESI ,  SCHUITMAKER JOHANNES

Inventor： SMIJS GEERTRUIDA MARIA THERESI ,  SCHUITMAKER JOHANNES

IPC: A61K31/409 ,  A61K41/00 ,  A61P31/10

CPC classification number: A61K31/409 ,  A61K41/0071 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for photodynamic treatment of a fungal skin disorder, said pharmaceutical composition comprising a photosensitizer and an enhancer, wherein the photosensitizer is a cationic photosensitizer and the enhancer is chosen from the group of i) an acid, and ii) a metal chelating agent. Such a composition is capable of eliminating both conidiae and hy- phae. The invention also relates to a method for the preparation of the pharmaceutical composition.

Abstract translation: 本发明涉及一种用于光动力治疗真菌皮肤病症的药物组合物，所述药物组合物包含光敏剂和增强剂，其中所述光敏剂是阳离子光敏剂，增强剂选自i）酸和ii ）金属螯合剂。 这种组合物能够消除分生孢子和海藻。 本发明还涉及制备药物组合物的方法。

公开(公告)号：WO2007008064A3

公开(公告)日：2007-05-03

申请号：PCT/NL2006000345

申请日：2006-07-07

Applicant: STICHTING TECH WETENSCHAPP ,  KOHLHEYER DIETRICH ,  SCHASFOORT RICHARDUS BERNARDUS

Inventor： KOHLHEYER DIETRICH ,  SCHASFOORT RICHARDUS BERNARDUS

IPC: G01N30/00 ,  G01N27/447 ,  G01N33/543

CPC classification number: G01N27/44743 ,  G01N27/44769 ,  G01N30/0005 ,  G01N33/543

Abstract: A device for separating, analysing, detecting and/or determining particles in a liquid sample flow, particularly a microchip (1), wherein the device (1) comprises: -at least one sample flow separation area (4); -a sample flow supply (2) to supply the sample flow (S) to said sample flow separation area (4); and -at least one field generator (5, 6) which is configured to generate a field to substantially laterally separate certain sample flow particles when the sample flow flows through said separation area (4), for example via separation by free flow electrophoresis, free flow isoelectric focusing and/or isotachophoresis ; wherein the device is provided with an at least 2-dimensional detection pattern (9) located at least partly in and/or downstream with respect to said separation area (4), wherein said detection pattern (9) is suitable to interact with certain sample flow particles to be detected and/or determined. The invention also provides a method for separating, analysing, detecting and/or determining particles in a liquid sample flow.

Abstract translation: 一种用于分离，分析，检测和/或确定液体样品流中的颗粒，特别是微芯片（1）的装置，其中所述装置（1）包括：至少一个样品流分离区域（4）; - 样品流供应（2），用于将样品流（S）供应到所述样品流分离区（4）; 以及 - 至少一个场发生器（5,6），其被配置为当样品流量流过所述分离区域（4）时，例如通过自由流动电泳分离，产生场以基本上横向分离某些样品流粒子，释放 流动等电聚焦和/或等速电泳; 其中所述装置具有至少部分地位于所述分离区域（4）的和/或下游的至少2维检测图案（9），其中所述检测图案（9）适于与特定样品 待检测和/或确定的流动颗粒。 本发明还提供了用于分离，分析，检测和/或确定液体样品流中的颗粒的方法。

公开(公告)号：WO2007011226A3

公开(公告)日：2007-03-29

申请号：PCT/NL2006050187

申请日：2006-07-21

Applicant: STICHTING TECH WETENSCHAPP ,  NIJDAM THIJS JOOST ,  JEURGENS LARS PETRUS HENRICUS ,  SLOOF WILLEM GERRIT

Inventor： NIJDAM THIJS JOOST ,  JEURGENS LARS PETRUS HENRICUS ,  SLOOF WILLEM GERRIT

IPC: C23C30/00 ,  C23C8/10 ,  C23C28/00

CPC classification number: C23C8/02 ,  C23C28/321 ,  C23C28/3215 ,  C23C28/345 ,  C23C28/3455 ,  Y02T50/67 ,  Y10T428/26

Abstract: Method for providing a thermal barrier coating and substrate . The thermal barrier coating (5) is provided on a thermally grown oxide (4) which is grown on a metallic bond coating (3) provided on said substrate (1) Adhesion between the bond coating (3) and thermally grown oxide coating (4) is improved by providing projections at the interface of yttriaalumina garnet (4) compounds. Service life at relatively high temperature of the thermally grown oxide coating (4) is improved by having alumina grain (6) with relatively large size. These are obtained by pre-annealing the bond coating (3) in an inert gas atmosphere followed by controlled preoxidation.

Abstract translation: 提供隔热涂层和基材的方法。 隔热涂层（5）设置在生长在设置在所述基板（1）上的金属粘合涂层（3）上的热生长氧化物（4）上。粘合涂层（3）和热生长氧化物涂层（4）之间的粘合 ）通过在氧化钇石榴石（4）化合物的界面处提供突起来改善。 通过具有较大尺寸的氧化铝颗粒（6）可以改善热生长氧化物涂层（4）的较高温度下的使用寿命。 这些是通过在惰性气体气氛中对粘合涂层（3）进行预退火，然后进行受控的预氧化而获得的。

公开(公告)号：WO2006096063B1

公开(公告)日：2006-11-23

申请号：PCT/NL2006050051

申请日：2006-03-10

Applicant: STICHTING TECH WETENSCHAPP ,  BROWN JANELLE L ,  HELLINGWERF KLAAS J ,  CRIELAARD WIM

Inventor： BROWN JANELLE L ,  HELLINGWERF KLAAS J ,  CRIELAARD WIM

IPC: C12N15/31 ,  C12N15/70 ,  C12Q1/68

CPC classification number: C12N15/70

Abstract: The present invention relates to constructs and methods for the screening, selection and identification of stress factors that disrupt the bioenergetics of the living cell, in particular the bioenergetics of the microbial cell. It provides in one aspect a promoter with an activity correalted to, and capable of serving as an indicator of change in the bioenergetics in the cell. It also provides fusion constructs and hosts comprising these constructs which may be used in the method of the invention. Thus, the invention allows for a rapid screening, selection and identification of stress factors for the cell, such as anti microbial compounds and antimicrobial treatments. These stress factors may be screened separately or in combination for their optimal effective concentration.

Abstract translation: 本发明涉及用于筛选，选择和鉴定破坏活细胞的生物能量的应激因子的构建体和方法，特别是微生物细胞的生物能量学。 它在一个方面提供了一种启动子，其具有与细胞中生物能量学变化相关的能力并且能够作为细胞中生物能量学变化的指标。 它还提供了可用于本发明方法的包含这些构建体的融合构建体和宿主。 因此，本发明允许快速筛选，选择和鉴定细胞的应激因子，例如抗微生物化合物和抗微生物处理。 这些应激因子可以单独或组合进行筛选以达到其最佳有效浓度。

公开(公告)号：WO2006001695A3

公开(公告)日：2006-02-16

申请号：PCT/NL2005000455

申请日：2005-06-24

Applicant: STICHTING TECH WETENSCHAPP ,  KRAMER NAOMI ESTHER ,  KUIPERS OSCAR PAUL

Inventor： KRAMER NAOMI ESTHER ,  KUIPERS OSCAR PAUL

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2565/601

Abstract: The present invention discloses a method for selecting a gene involved with nisin-resistance in a species of bacteria comprising providing candidate genes that are differentially expressed in nisin-resistant and sensitive strains of said species and selecting from said candidate genes at least one gene that results in an altered nisin-resistance phenotype in a strain of said species, when expression of said gene is altered. The invention further provides a bacterial strain obtained by the method of the invention, and a method for fermenting dairy products with said bacterial strain. The invention also discloses cheese produced by fermentation according to the invention.

Abstract translation: 本发明公开了一种选择涉及细菌中的乳链菌肽抗性的基因的方法，包括提供在所述物种的乳链菌肽抗性和敏感菌株中差异表达的候选基因，并从所述候选基因中选择至少一种产生的基因 当所述基因的表达改变时，所述物种的菌株中改变的乳链菌肽抗性表型。 本发明还提供了通过本发明的方法获得的细菌菌株和用所述细菌菌株发酵乳制品的方法。 本发明还公开了根据本发明通过发酵生产的奶酪。

公开(公告)号：WO2004090164A2

公开(公告)日：2004-10-21

申请号：PCT/NL2004000247

申请日：2004-04-14

Applicant: STICHTING TECH WETENSCHAPP ,  HELDER JOHANNES ,  VAN DEN ELSEN SVEN JOHANNES JO ,  BONGERS ALBERTHUS MARIA THEODO ,  VAN DER WURFF ADRIANUS WILHELM ,  BAKKER JAAP ,  KAMMENGA JAN EDWARD

Inventor： HELDER JOHANNES ,  VAN DEN ELSEN SVEN JOHANNES JO ,  BONGERS ALBERTHUS MARIA THEODO ,  VAN DER WURFF ADRIANUS WILHELM ,  BAKKER JAAP ,  KAMMENGA JAN EDWARD

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q2600/156

Abstract: The present invention relates to the use of at least one of the single nucleotide polymorphisms (SNPs) referred to in Table 7 for detecting lower taxonomic groups of nematodes, for determining a life strategy of a nematode, for determining the biodiversity of a soil sample or for determining the soil health.

Abstract translation: 本发明涉及表7中提及的单核苷酸多态性（SNP）中至少一种用于检测较低的线虫分类群，用于确定线虫的寿命策略，用于确定土壤样品的生物多样性或 用于确定土壤健康。