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    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER
    31.
    发明专利
    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER 未知

    公开(公告)号：SG187101A1

    公开(公告)日：2013-02-28

    申请号：SG2013003553

    申请日：2011-07-15

    Applicant: STICHTING VU VUMC

    Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT
    32.
    发明公开
    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT 审中-公开
    植入种植牙的套件

    公开(公告)号：EP3193772A1

    公开(公告)日：2017-07-26

    申请号：EP14777392.3

    申请日：2014-09-19

    Applicant: Stichting VU-VUmc

    Inventor： KOOPS, Daniël

    IPC: A61C1/08 ,  A61C8/00

    CPC classification number: A61C8/0089 ,  A61C1/084 ,  A61C8/0087

    Abstract: The kit comprises a stop element comprising a first part and a second part, wherein the first part and the second part are configured to be movable between a first state, in which the first part and the second part are spaced at a first distance, and a second state, in which the first part and the second part are spaced at a second distance, wherein the first distance is smaller than the second distance, and wherein the first and second parts are biased to the first state, wherein the second distance is the same or larger than a distance between diametrically opposite sides of the outer surface of the implant guide, such that, before implantation, the first part and the second part can be arranged, in the second state, on diametrically opposite sides of the outer surface, and that during movement in the implantation direction of the dental implant into the jaw, the stop surface of the implantation channel will push the stop element towards the groove until the groove will allow the first and second part to move towards the first state and the stop element will be caught by the groove, therewith blocking further movement of the implant guide in the implantation direction.

    Abstract translation: 本发明提供了一种用于植入牙科植入物的套件，其包括植入物引导件，该植入物引导件包括近端和远端，其中远端被构造成可拆卸地附接到牙植入物，所述植入物引导件包括圆柱形 其中所述圆柱形主体包括圆柱形外表面和在所述外表面中的周向凹槽，以及模板，所述模板被构造成相对于钳口布置在预定位置处，其中所述模板包括至少一个植入通道，以引导所述圆柱形 在植入颌骨期间的植入物引导件的期望植入方向上的植入物导向件和植入通道的端部处的止动表面。 该套件包括止动元件，该止动元件包括第一部分和第二部分，其中第一部分和第二部分构造成可在第一状态和第二部分之间移动，在第一状态下第一部分和第二部分以第一距离间隔开， 第二状态，其中所述第一部分和所述第二部分以第二距离间隔开，其中所述第一距离小于所述第二距离，并且其中所述第一和第二部分偏置到所述第一状态，其中所述第二距离是 所述第一部分和所述第二部分可以在所述植入引导件的外表面的径向相对侧之间的距离相同或大于所述植入引导件的外表面的径向相对侧之间的距离，使得在植入之前，所述第一部分和所述第二部分可以在所述第二状态中布置在所述外表面 并且在牙科植入物植入颌中的植入方向移动期间，植入通道的止动表面将朝向凹槽推动止动元件，直到凹槽将允许冷杉 第一部分和第二部分向第一状态移动，并且止动元件将被凹槽卡住，从而阻止植入引导件在植入方向上的进一步移动。

    SYSTEM AND METHOD FOR NETWORK SYNCHRONIZATION AND FREQUENCY DISSEMINATION
    33.
    发明公开
    SYSTEM AND METHOD FOR NETWORK SYNCHRONIZATION AND FREQUENCY DISSEMINATION 审中-公开
    系统和方法进行网络同步和频率分布

    公开(公告)号：EP2715955A1

    公开(公告)日：2014-04-09

    申请号：EP12725889.5

    申请日：2012-05-24

    Applicant: Stichting VU-VUmc ,  Nuijts, Roeland Johannus Marie Wilhelm

    Inventor： NUIJTS, Roeland Johannus Marie Wilhelm ,  KOELEMEIJ, Jeroen Cornelis Jean

    IPC: H04J3/06 ,  H04J14/02

    CPC classification number: H04L7/0075 ,  H04J3/0682 ,  H04J14/02 ,  H04J14/0272 ,  H04J14/0275

    Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream. In an embodiment wherein the network provides for an optical supervisory channel, the optical filters for combining the optical supervisory channel signal with the unidirectional data signal and separating the optical supervisory channel signal from the unidirectional data signal are used to combine and separate the reference frequency and timing signal and to pass the optical return timing signal. For this purpose, further optical filters may be added outside the main optical data channel to combine and separate the reference frequency and timing signal and the optical supervisory channel and to pass the optical return signal back to the filter that separates the optical supervisory channel signal from the data signal.

    METHOD OF LAYERED OBJECT MANUFACTURING, SHEET ELEMENT, OBJECT MANUFACTURING DEVICE, AND OBJECT
    34.
    发明申请
    METHOD OF LAYERED OBJECT MANUFACTURING, SHEET ELEMENT, OBJECT MANUFACTURING DEVICE, AND OBJECT 审中-公开
    层状物体制造方法，片材元件，物体制造装置和物体

    公开(公告)号：WO2016068697A1

    公开(公告)日：2016-05-06

    申请号：PCT/NL2015/050742

    申请日：2015-10-27

    Applicant: STICHTING VU-VUMC

    Inventor： BOS, Ernst Jan

    IPC: B29C67/00

    CPC classification number: B29C64/141

    Abstract: The present invention provides a method of layered object manufacturing using multiple sheet elements each having a predetermined dimension, wherein the sheet elements comprise first interlocking elements configured to interlock with at least a first further sheet element arranged at a first side of the sheet element, and second interlocking elements configured to interlock with at least a second further sheet element arranged at a second side of the sheet element, wherein the second side is opposite the first side. The method comprises stacking the multiple sheet elements on top of each other, wherein the first interlocking elements of a first one of the multiple sheet elements interlock with the second interlocking elements of a second one of the multiple sheet elements arranged at the first side of the first sheet element, and the second interlocking elements interlock with first interlocking elements of a third one of the multiple sheet elements arranged at the second side of the first sheet element. The invention also provides a sheet element, an object manufacturing device, and object constructed with the method.

    Abstract translation: 本发明提供了一种使用多个片材元件的分层物体制造方法，每个片材元件具有预定的尺寸，其中片材元件包括构造成与布置在片材元件的第一侧的至少第一另外的片元件互锁的第一互锁元件，以及 第二互锁元件构造成与布置在片材元件的第二侧处的至少第二另外的片元件互锁，其中第二侧与第一侧相对。 该方法包括将多个片材元件堆叠在彼此的顶部上，其中多个片材元件中的第一个片材的第一互锁元件与布置在第一侧面上的多个片状元件中的第二个互补元件的第二互锁元件互锁 第一片状元件，并且第二互锁元件与布置在第一片元件的第二侧的多个片状元件中的第三个的第一互锁元件互锁。 本发明还提供了一种片材元件，一种物体制造装置和用该方法构造的物体。

    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER
    39.
    发明申请
    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER 审中-公开
    一种分析疾病标记物存在的受试者血样的方法

    公开(公告)号：WO2012008839A9

    公开(公告)日：2012-05-03

    申请号：PCT/NL2011050518

    申请日：2011-07-15

    Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    IPC: G01N33/48

    CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

    Abstract translation: 本发明涉及分析受试者的血液样品中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的无核血细胞中提取核酸以提供无核血细胞提取 核酸组分，和b）分析所述无核血细胞提取的核酸组分是否存在疾病标志物，其中所述疾病标志物是所述对象细胞基因中的疾病特异性突变，或其中所述疾病标志物 是所述受试者细胞的基因的疾病特异性表达谱。

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