公开(公告)号：SG187101A1

公开(公告)日：2013-02-28

申请号：SG2013003553

申请日：2011-07-15

Applicant: STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：WO2012008839A9

公开(公告)日：2012-05-03

申请号：PCT/NL2011050518

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及分析受试者的血液样品中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的无核血细胞中提取核酸以提供无核血细胞提取 核酸组分，和b）分析所述无核血细胞提取的核酸组分是否存在疾病标志物，其中所述疾病标志物是所述对象细胞基因中的疾病特异性突变，或其中所述疾病标志物 是所述受试者细胞的基因的疾病特异性表达谱。

公开(公告)号：WO2012008839A3

公开(公告)日：2012-03-01

申请号：PCT/NL2011050518

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：SG193539A1

公开(公告)日：2013-10-30

申请号：SG2013070487

申请日：2012-01-16

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：MX2013000606A

公开(公告)日：2013-06-28

申请号：MX2013000606

申请日：2011-07-15

Applicant: STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

Abstract: La presente invención se relaciona con un método para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad, dicho método comprende los pasos de a) extraer ácido nucleico de las células de sangre enucleadas en la muestra de sangre, para proporcionar una fracción de ácido nucleico extraída de células de sangre enucleadas, y b) analizar la fracción de ácido nucleico extraída de células de sangre enucleadas por la presencia de un marcador de enfermedad, en donde el marcador de enfermedad es una mutación específica de la enfermedad en un gen de una célula del sujeto, o en donde el marcador de enfermedad es un perfil de expresión específico de enfermedad de genes de una célula del sujeto.

公开(公告)号：CA2805586C

公开(公告)日：2020-09-01

申请号：CA2805586

申请日：2011-07-15

Applicant: STICHTING VU VUMC

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.