公开(公告)号：WO2012046255A2

公开(公告)日：2012-04-12

申请号：PCT/IN2011/000703

申请日：2011-10-10

Applicant: CADILA HEALTHCARE LIMITED ,  PARIKH, Aashini ,  SINGH, Arun ,  MENDIRATTA, Sanjeev Kumar ,  GUPTA, Ajit K ,  JAKHADE, Mansi

Inventor： PARIKH, Aashini ,  SINGH, Arun ,  GUPTA, Ajit K ,  JAKHADE, Mansi

IPC: C12N15/85

CPC classification number: C12N15/85 ,  C12N9/6459 ,  C12N15/68 ,  C12N2830/42 ,  C12N2830/46 ,  C12N2840/203 ,  C12P21/00 ,  C12Y304/21069

Abstract: The present invention provides an expression vector for the production of proteins and peptides comprising a promoter operably linked to gene of interest, TPL and VA genes I and II, matrix attachment regions (MARs)/SARs, antibiotic marker. The said vector is transfected in suitable host cell.

Abstract translation: 本发明提供了用于产生蛋白质和肽的表达载体，其包含可操作地连接到目标基因，TPL和VA基因I和II，基质附着区域（MAR）/ SARs，抗生素标记物的启动子。 将所述载体转染在合适的宿主细胞中。

公开(公告)号：WO2011080684A9

公开(公告)日：2011-10-20

申请号：PCT/IB2010056066

申请日：2010-12-23

Applicant: RANBAXY LAB LTD ,  SINGH KAPTAN ,  SANJEEVI LAKSHMIPATHI V ,  SHIRSATH KRISHNARAO TUKARAM ,  ARORA SANJEEV KUMAR ,  KUMAR ASHOK ,  ALLADA SURESH

Inventor： SINGH KAPTAN ,  SANJEEVI LAKSHMIPATHI V ,  SHIRSATH KRISHNARAO TUKARAM ,  ARORA SANJEEV KUMAR ,  KUMAR ASHOK ,  ALLADA SURESH

IPC: C07D403/10

CPC classification number: C07D403/10 ,  Y02P20/55

Abstract: The present invention provides an improved process for the preparation of candesartan and pharmaceutically acceptable salts and esters thereof for use in the treatment of hypertension and related diseases. Specifically, it refers to the deprotection of tetrazolyl -protecting group of candesartan or its derivative in the presence of iodine in one or more alcoholic solvents.

Abstract translation: 本发明提供了制备用于治疗高血压和相关疾病的坎地沙坦及其药学上可接受的盐和酯的改进方法。 具体地说，它是指在一种或多种醇溶剂中碘存在下坎地沙坦或其衍生物的四唑基保护基团的脱保护。

公开(公告)号：WO2011080684A4

公开(公告)日：2011-07-07

申请号：PCT/IB2010/056066

申请日：2010-12-23

Applicant: RANBAXY LABORATORIES LIMITED ,  SINGH, Kaptan ,  SANJEEVI, Lakshmipathi V. ,  SHIRSATH, Krishnarao Tukaram ,  ARORA, Sanjeev Kumar ,  KUMAR, Ashok ,  ALLADA, Suresh

Inventor： SINGH, Kaptan ,  SANJEEVI, Lakshmipathi V. ,  SHIRSATH, Krishnarao Tukaram ,  ARORA, Sanjeev Kumar ,  KUMAR, Ashok ,  ALLADA, Suresh

IPC: C07D403/10

Abstract: The present invention provides an improved process for the preparation of candesartan and pharmaceutically acceptable salts and esters thereof for use in the treatment of hypertension and related diseases. Specifically, it refers to the deprotection of tetrazolyl -protecting group of candesartan or its derivative in the presence of iodine in one or more alcoholic solvents.

公开(公告)号：WO2011060049A2

公开(公告)日：2011-05-19

申请号：PCT/US2010/056197

申请日：2010-11-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  WANG, Shaomeng ,  YU, Shanghai ,  SUN, Wei ,  SHANGARY, Sanjeev Kumar ,  SUN, Duxin ,  ZOU, Peng ,  ZHAO, Yujun ,  MCEACHERN, Donna

Inventor： WANG, Shaomeng ,  YU, Shanghai ,  SUN, Wei ,  SHANGARY, Sanjeev Kumar ,  SUN, Duxin ,  ZOU, Peng ,  ZHAO, Yujun ,  MCEACHERN, Donna

CPC classification number: C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract translation: 本文提供了药物化学领域中的化合物，组合物和方法。 本文提供的化合物和组合物涉及用作p53和MDM2之间相互作用的拮抗剂的螺 - 羟吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

公开(公告)号：WO2009066320A3

公开(公告)日：2009-09-24

申请号：PCT/IN2008000599

申请日：2008-09-22

Applicant: CADILA HEALTHCARE LTD ,  MENDIRETTA SANJEEV KUMAR ,  PATEL PANKAJ R ,  BANDYOPADHYAY SANJAY ,  SARASWAT VIBHOR ,  SINGH ARUN KUMAR

Inventor： MENDIRETTA SANJEEV KUMAR ,  PATEL PANKAJ R ,  BANDYOPADHYAY SANJAY ,  SARASWAT VIBHOR ,  SINGH ARUN KUMAR

IPC: C12N15/62

CPC classification number: C12N15/62 ,  C07K14/535 ,  C07K14/62 ,  C07K14/635 ,  C12P21/02

Abstract: The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.

Abstract translation: 本发明公开了通过使用G-CSF作为这些细胞中高水平表达的新型融合配偶体从细菌细胞中产生所需重组肽的改进方法。 本发明还提供了包含融合蛋白的表达系统，其中G-CSF通过酶或化学切割位点可操作地连接到目的肽，其可用于从融合配偶体与所述肽分离。

公开(公告)号：WO2008032334A8

公开(公告)日：2008-09-04

申请号：PCT/IN2006000456

申请日：2006-11-17

Applicant: JUBILANT ORGANOSYS LTD ,  KUMAR MAHENDRA ,  DIXIT SANJEEV KUMAR ,  SINGH SHAILENDRA KUMAR ,  AGARWAL ASHUTOSH

Inventor： KUMAR MAHENDRA ,  DIXIT SANJEEV KUMAR ,  SINGH SHAILENDRA KUMAR ,  AGARWAL ASHUTOSH

IPC: C07D213/06

CPC classification number: C07D213/06

Abstract: Disclosed herein is a process for recovery of pyridine and/or its derivatives from their aqueous mass and/ or manufacturing reaction mass by liquid-liquid extraction employing an environmentally non-hazardous organic solvent. The process further comprising effective recovering and recycle of solvents from the aqueous phase and the other waste obtained during the process.

Abstract translation: 本文公开了使用环境无害的有机溶剂通过液 - 液萃取从其水性物质和/或制造反应物质中回收吡啶和/或其衍生物的方法。 该方法还包括有效回收和再循环来自水相和在该过程中获得的其他废物中的溶剂。

公开(公告)号：WO2008062481A2

公开(公告)日：2008-05-29

申请号：PCT/IN2007/000549

申请日：2007-11-16

Applicant: CADILA HEALTHCARE LIMITED ,  BANDYOPADHYAY, Sanjay ,  NATARAJAN, Venkatesan ,  MENDIRATTA, Sanjeev, Kumar ,  PATEL, Pankaj, Ramanbhai

Inventor： BANDYOPADHYAY, Sanjay ,  NATARAJAN, Venkatesan ,  MENDIRATTA, Sanjeev, Kumar ,  PATEL, Pankaj, Ramanbhai

IPC: A61K9/00 ,  A61K9/19 ,  A61K38/21 ,  A61K38/43 ,  A61K47/02 ,  A61K47/26

CPC classification number: A61K9/19 ,  A61K9/0019 ,  A61K38/212 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/60

Abstract: The present invention relates to novel lyophilized and stabilized formulations of PEG-Interferon alpha conjugates and the process for their preparation. The novel formulations of PEG-Interferon alpha conjugates reported by the inventors of this application requires less lyophilization cycle and are more cost competitive.

Abstract translation: 本发明涉及PEG-干扰素α缀合物的新型冻干和稳定化制剂及其制备方法。 由本申请的发明人报道的PEG-干扰素α缀合物的新制剂需要较少的冻干循环并且成本更具竞争力。

公开(公告)号：WO2007102174A2

公开(公告)日：2007-09-13

申请号：PCT/IN2007/000105

申请日：2007-03-05

Applicant: CADILA HEALTHCARE LIMITED ,  MENDIRATTA, Sanjeev, Kumar ,  SARASWAT, Vibhor ,  PATEL, Pankaj, R.

Inventor： MENDIRATTA, Sanjeev, Kumar ,  SARASWAT, Vibhor ,  PATEL, Pankaj, R.

IPC: C12N1/00

CPC classification number: C07K14/535 ,  C12N1/20

Abstract: The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.

Abstract translation: 本发明公开了一种通过在生产阶段通过高盐诱导的质粒稳定性增加而以高产率生产G-CSF的改进方法。

公开(公告)号：WO2007029082A3

公开(公告)日：2007-04-26

申请号：PCT/IB2006002409

申请日：2006-09-01

Applicant: RANBAXY LAB LTD ,  KUMAR PARVEEN ,  SHARMA SANJEEV KUMAR ,  MALVIYA HITESH KUMAR ,  BALASUBRAMANIAN RAMANCHANDRAN ,  DALAL ASHUBHAI

Inventor： KUMAR PARVEEN ,  SHARMA SANJEEV KUMAR ,  MALVIYA HITESH KUMAR ,  BALASUBRAMANIAN RAMANCHANDRAN ,  DALAL ASHUBHAI

IPC: C07D498/18 ,  C07H19/01

CPC classification number: C07D498/18 ,  C12P17/188

Abstract: The present invention relates to an improved fermentation process for the preparation of ascomycin.

Abstract translation: 本发明涉及用于制备子囊霉素的改进的发酵方法。

公开(公告)号：WO2005051362A3

公开(公告)日：2005-10-20

申请号：PCT/IB2004003865

申请日：2004-11-24

Applicant: RANBAXY LAB LTD ,  DUBEY VIVEK MAHENDRAKUMAR ,  RAO VISINGIRI VENKAT RAM MOHAN ,  DESHMUKH ABHIJIT MUKUND ,  SETHI SANJEEV KUMAR

Inventor： DUBEY VIVEK MAHENDRAKUMAR ,  RAO VISINGIRI VENKAT RAM MOHAN ,  DESHMUKH ABHIJIT MUKUND ,  SETHI SANJEEV KUMAR

IPC: A61K9/28 ,  A61K9/50 ,  A61K31/4439 ,  A61P1/04

CPC classification number: A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/5078 ,  A61K31/4439

Abstract: The present invention relates to stable oral benzimidazole compositions and processes for their preparation.

Abstract translation: 本发明涉及稳定的口服苯并咪唑组合物及其制备方法。