METHOD OF IDENTIFYING ENERGY TRANSFER SENSORS FOR ANALYTES
    32.
    发明申请
    METHOD OF IDENTIFYING ENERGY TRANSFER SENSORS FOR ANALYTES 审中-公开
    识别能量转移传感器的方法

    公开(公告)号:WO2003040670A2

    公开(公告)日:2003-05-15

    申请号:PCT/US2002/036045

    申请日:2002-11-07

    Inventor: DAVID, Wolf, E.

    IPC: G01J

    CPC classification number: G01N33/542

    Abstract: A method of identifying an analyte-ligand binding pair that exhibits non-radiative fluorescence resonance energy transfer (FRET) using a combinatorial library. The method includes a) obtaining an analyte binding ligand from a combinatorial library that includes ligands, and b) attaching a label at least one of the analyte binding ligand and an analyte­analogue with at least one of a first component and a second component of a non-radiative fluorescence resonance energy transfer donor-acceptor pair (FRET pair) such that FRET occurs when the analyte-analogue is bound to the analyte binding ligand, and a change in FRET occurs when the analyte-analogue is not bound to the analyte binding ligand. The method also includes contacting a combinatorial library of ligands, which are optionally labeled with a component of a FRET pair, with analyte-analogue, which is optionally labeled with a component of a FRET pair, and detecting the presence of FRET.

    Abstract translation: 鉴定使用组合文库显示非辐射荧光共振能量转移FRET的分析物 - 配体结合对的方法。 该方法包括从包括配体的组合文库中获得分析物结合配体,以及b将标记物至少一个分析物结合配体和被分析物分析物与非辐射的第一组分和第二组分中的至少一个连接 荧光共振能量转移供体 - 受体对FRET对,使得当分析物 - 类似物与分析物结合配体结合时发生FRET,并且当分析物 - 类似物不结合到分析物结合配体时,发生FRET的变化。 该方法还包括将任选地标记有FRET对的组分的配体的组合文库与分析物 - 类似物(其任选地用FRET对的组分标记)并检测FRET的存在的接触。

    DEVICES, SYSTEMS, AND METHODS FOR MEASURING FLUID LEVEL USING RADIO-FREQUENCY (RF) LOCALIZATION

    公开(公告)号:WO2022173869A1

    公开(公告)日:2022-08-18

    申请号:PCT/US2022/015873

    申请日:2022-02-09

    Abstract: Disclosed herein are devices, systems, and methods for accurately determining fluid level using Ultra Wideband (UWB) positioning or localization. UWB utilizes a radio-frequency (RF) technology to enable the accurate measurement of the time-of-flight of a radio signal and UWB positioning can operate in Time-Difference-of- Arrival (TDoA) mode, Two-Way- Ranging (TWR) mode, and Phase-Difference-of- Arrival (PDoA) mode. The systems disclosed herein include multiple anchor devices having a UWB antenna(s) and positioned in fixed location(s) over the fluid to be measured. The anchor devices serve as reference points for UWB communication with a remote float device, which emits RF signals and floats on the surface of the fluid to be measured. The anchor devices may include, or be in communication with, a processor which receives and/or measures RF signals, generates timestamps, calculates distance(s) between the remote float device and an anchor device, calculates fluid level, calculates an angle-of-arrival (AoA), or any combination thereof.

    NON-LINEAR ULTRASOUND METHOD AND APPARATUS FOR QUANTITATIVE DETECTION OF MATERIALS (LIQUIDS, GAS, PLASMA)

    公开(公告)号:WO2020243628A1

    公开(公告)日:2020-12-03

    申请号:PCT/US2020/035404

    申请日:2020-05-29

    Inventor: HEIM, James, M.

    Abstract: Systems and methods for determining a weight of a quantity of fluid, or a flow rate of the fluid by weight. An acoustic sensor positioned on an exterior wall of a vessel containing the fluid determines a fill level of the fluid. A computerized device calculates a weight of the quantity of fluid using a size of the vessel, the determined fill level, a temperature of the fluid, and the fluid identity and/or a fluid density. Flow rate of the fluid through a pipe is determined using two or more acoustic sensors positioned at different locations on a pipe, and a temperature sensor. A computer calculates a differential time of flight of the fluid based on readings of the acoustic sensor, a distance therebetween, the temperature sensor, the pipe volume, and the fluid identity and/or a fluid density. A flow by weight of the quantity of fluid is determined.

    Non-linear ultrasound method and apparatus for quantitative detection of materials

    公开(公告)号:US11846537B2

    公开(公告)日:2023-12-19

    申请号:US17540021

    申请日:2021-12-01

    CPC classification number: G01F23/2965 G01N29/02 G08B21/18

    Abstract: Systems and methods for determining a fill level of a fluid within a fluid vessel, an identity of the fluid, and/or a condition of the vessel wall are disclosed. To determine a fluid fill level, at least one acoustic sensor is positionable substantially on an exterior sidewall of a vessel containing fluid. A computerized device is in communication with the at least one acoustic sensor. A processor of the computerized device receives a detection signal from the at least one acoustic sensor and communicates an alert of the detection signal, which can be used to identify a fill level of the fluid. The detection signal, along with other measured information, can be used to identify the material type of the fluid. A condition of the vessel wall may be determined based on an attenuation signal when two acoustic sensors are used, one being positioned angular to the vessel wall.

    VARIABLE ANGLE TRANSDUCER INTERFACE BLOCK

    公开(公告)号:US20220174380A1

    公开(公告)日:2022-06-02

    申请号:US17541036

    申请日:2021-12-02

    Abstract: A variable angle transducer interface block apparatus and related systems and methods are disclosed. The variable angle transducer interface block apparatus has an interface block having a mounting receiver. The interface block is positioned proximate to a material wall. A curved mounting structure is movably connected to the mounting receiver. A transducer is mounted on the curved mounting structure, wherein an angle of an acoustic signal transmitted by the transducer into the material wall is adjustable by movement of the curved mounting structure relative to the mounting receiver.

    NON-LINEAR ULTRASOUND METHOD AND APPARATUS FOR QUANTITATIVE DETECTION OF MATERIALS

    公开(公告)号:US20220090956A1

    公开(公告)日:2022-03-24

    申请号:US17540021

    申请日:2021-12-01

    Abstract: Systems and methods for determining a fill level of a fluid within a fluid vessel, an identity of the fluid, and/or a condition of the vessel wall are disclosed. To determine a fluid fill level, at least one acoustic sensor is positionable substantially on an exterior sidewall of a vessel containing fluid. A computerized device is in communication with the at least one acoustic sensor. A processor of the computerized device receives a detection signal from the at least one acoustic sensor and communicates an alert of the detection signal, which can be used to identify a fill level of the fluid. The detection signal, along with other measured information, can be used to identify the material type of the fluid. A condition of the vessel wall may be determined based on an attenuation signal when two acoustic sensors are used, one being positioned angular to the vessel wall.

    Device and method for sensing underwater sound pressure

    公开(公告)号:US11616190B2

    公开(公告)日:2023-03-28

    申请号:US16955215

    申请日:2018-12-20

    Abstract: A hydrophone may include a first piezoelectric cable including alternating sections of positive polarity and negative polarity, and a second piezoelectric cable including alternating sections of negative polarity and positive polarity. At least a portion of each section of positive polarity of the first piezoelectric cable may be bonded or adhered to at least a portion of a section of negative polarity of the second piezoelectric cable. A method of manufacturing a hydrophone may include winding or coiling a first piezoelectric cable and a second piezoelectric cable at the same time to create a series of wound sections including cables, the wound sections alternating with a series of not wound sections including the cables.

    PORTABLE ATMOSPHERIC MONITOR
    40.
    发明申请

    公开(公告)号:US20220136950A1

    公开(公告)日:2022-05-05

    申请号:US17602147

    申请日:2020-04-09

    Abstract: In certain embodiments, a portable atmospheric monitor comprises a housing at least partially enclosing an inner chamber. The housing comprises an inlet and an aperture. The monitor also includes at least one light sensor arranged within the housing. The light sensor that senses one or more wavelengths of sunlight received via the aperture. The monitor includes at least one light-scattering sensor that senses PM received via the inlet. The monitor includes a processor arranged within the housing and coupled to the at least one light sensor and the at least one light-scattering sensor. The processor is configured to: receive a light signal from the at least one light sensor; receive a PM signal from the at least one light-scattering sensor; determine the aerosol optical depth based upon the light signal; and determine the PM concentration based upon the PM signal.

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