公开(公告)号：CA2529286A1

公开(公告)日：2004-12-29

申请号：CA2529286

申请日：2004-06-18

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： WOLF DAVID E

IPC: G01N21/77 ,  A61B5/00 ,  A61B5/07 ,  G01N21/64 ,  G01N33/543

Abstract: A system for detecting analyte that includes a sensor adapted to detect the analyte, the sensor including a polymer matrix, fluorophores and a membrane, an excitation source to excite a fluorophore of the sensor, a first detector adapted to detect light of a first wavelength emitted by the sensor, a secon d detector adapted to detect light of a second wavelength emitted by the senso r, and a processor for processing signals corresponding to light detected by th e detectors.

公开(公告)号：CA2539885A1

公开(公告)日：2005-05-19

申请号：CA2539885

申请日：2004-10-28

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： WOLF DAVID E

IPC: A61B5/00 ,  A61K49/00 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66

Abstract: A sensor for detecting an analyte is disclosed that includes a core including hydrogel, fluorescence reagent disposed in the core, a semipermeable coating surrounding the core, the semipermeable coating including a polydisperse polymer having a molecular weight from about 4 kDa to about 18 kDa and a polydispersity index greater than 1 and a biocompatible coating surrounding the semipermeable coating.

公开(公告)号：AU2003259056A1

公开(公告)日：2004-02-23

申请号：AU2003259056

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： WOLF DAVID E ,  BULSECO DYLAN A

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument that includes an excitation source, at least one of a light focusing element positioned to receive light emitted by the excitation source, a detector for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupled to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

公开(公告)号：CA2494478A1

公开(公告)日：2004-02-12

申请号：CA2494478

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： BULSECO DYLAN A ,  WOLF DAVID E

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: Disclosed is a portable fluorescence correlation spectroscopy instrument tha t includes an excitation source (10), at least one of alight focusing element (12) positioned to receive light emitted by the excitation source, a detecto r (40a, 40b) for detecting light, the detector positioned to receive light emitted by a sample excited by the excitation source, and a correlator coupl ed to the detector, the correlator for processing data received at the detector and providing data including autocorrelation data, crosscorrelation data, or a combination thereof.

公开(公告)号：CA2493993A1

公开(公告)日：2004-02-12

申请号：CA2493993

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： BULSECO DYLAN A ,  WOLF DAVID E

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

Abstract: The invention features a method of assaying for the interaction of a probe a nd an unknown target, said method including a) exciting a sample with radiation , the sample including at least one unknown target, at least one probe, and at least one fluorescent tag, b) measuring the fluorescence from a subvolume of the sample, and c) analyzing the fluctuations of the fluorescence.

公开(公告)号：AU2007249147A1

公开(公告)日：2008-01-31

申请号：AU2007249147

申请日：2007-12-20

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： BULSECO DYLAN A ,  WOLF DAVID E

IPC: G01J3/44 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58

公开(公告)号：WO2004013610A3

公开(公告)日：2004-05-21

申请号：PCT/US0324780

申请日：2003-08-01

Applicant: SENSOR TECHNOLOGIES LLC

Inventor： WOLF DAVID E ,  BULSECO DYLAN A

IPC: C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58 ,  G12Q1/68 ,  C07H21/04 ,  C12M1/36 ,  C12P19/34

CPC classification number: G01N21/6428 ,  G01J3/4406 ,  G01J3/457 ,  G01N21/645 ,  G01N33/582 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484

Abstract: The invention features a method of assaying for the interaction of a probe and an unknown target, said method including a) exciting a sample with radiation, the sample including at least one unknown target, at least one probe, and at least one fluorescent tag, b) measuring the fluorescence from a subvolume of the sample, and c) analyzing the fluctuations of the fluorescence.

Abstract translation: 本发明的特征在于测定探针与未知靶标的相互作用的方法，所述方法包括a）用辐射激发样品，所述样品包括至少一个未知靶标，至少一个探针和至少一个荧光标签， b）测量来自样品的亚体积的荧光，以及c）分析荧光的波动。