公开(公告)号：WO2014062985A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/065548

申请日：2013-10-17

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  CHILDREN'S NATIONAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： AYYUB, Omar Bilal ,  BEHRENS, Adam Michael ,  KOFINAS, Peter ,  SUMMAR, Marshall Lynn ,  CABRERA-LUQUE, Juan Manuel ,  CUNNINGHAM, Gary ,  SIMEONOV, Anton ,  MARUGAN, Juan

IPC: G01N17/04 ,  G01F1/64 ,  C12N9/00 ,  C12N11/00

CPC classification number: C12Q1/005 ,  C12N9/0018 ,  C12N9/0071 ,  C12N11/04 ,  C12N11/10 ,  G01N27/3277 ,  G01N33/6812 ,  G01N2800/04 ,  G01N2800/52

Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.

Abstract translation: 本发明涉及能够使用包含由水凝胶改性的电极的无试剂系统来测量一种或多种氨基酸的总浓度的生物传感器，该电极包含至少一种氧化至少一种至少一种至少一种底物的酶 一个氨基酸。 在一些实施方案中，生物传感器包含包含藻酸盐的水凝胶。 在一些实施方案中，生物传感器包括使用固定或附着在水凝胶上的嗜热细菌代谢酶。

公开(公告)号：WO2007084700A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/001501

申请日：2007-01-19

Applicant: UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  WEN, Xingzhi ,  VISHKIN, Uzi, Yehoshua

Inventor： WEN, Xingzhi ,  VISHKIN, Uzi, Yehoshua

IPC: G06F9/48

Abstract: An Explicit Multi-Threading (XMT) system and method is provided for processing multiple spawned threads associated with SPAWN-type commands of an XMT program. The method includes executing a plurality of child threads by a plurality of TCUs including a first TCU executing a child thread which is allocated to it; completing execution of the child thread by the first TCU; announcing that the first TCU is available to execute another child thread; executing by a second TCU a parent child thread that includes a nested spawn-type command for spawning additional child threads of the plurality of child threads, wherein the parent child thread is related in a parent-child relationship to the child threads that are spawned in conjunction with the nested spawn-type command; assigning a thread ID (TID) to each child thread, wherein the TID is unique with respect to the other TIDs; and allocating a new child thread to the first TCU.

公开(公告)号：WO2005076671A8

公开(公告)日：2005-10-27

申请号：PCT/RU2004000041

申请日：2004-02-06

Applicant: IVANOV VLADIMIR ALEXANDROVICH ,  SUKHOMLINOV VLADIMIR SERGEEVIC ,  TECHNOLOGY COMMERCIALIZATION

Inventor： IVANOV VLADIMIR ALEXANDROVICH ,  SUKHOMLINOV VLADIMIR SERGEEVIC

IPC: G01J3/10 ,  H05B31/00 ,  H05B31/36 ,  H05B41/16 ,  G01J3/08 ,  H05B41/23 ,  H05B41/24 ,  H05B41/26

CPC classification number: H05B31/0003 ,  G01J3/10 ,  H05B31/36

Abstract: The invention relates to spectral instrument engineering and is used for exciting spectra for spectral analysis. The aim of said invention is to develop a small-sized multi-purpose arc spectrum excitation source for alternate and constant voltage having a high performance and a high discharge current stability which makes it possible to set the required value of the arc current prior to the initiation thereof. The inventive arc discharge generator comprises a power supply circuit, a circuit for forming arc current provided with switching transistors, a current-responsive resistance provided with an operating amplifier connected thereto, an LC circuit provided with electrodes connected thereto, a unit for forming a high-voltage arc initiation pulse and a control unit. The circuit for forming arc current comprises a multi-level comparator and a special-purpose processor, a capacitor and an inductance being serially connected to the electrodes. Said multilevel comparator is connected, through the operating amplifiers, to a resistor and the special-purpose processor which calculates the mean square value of a resistive voltage drop. An additional key is connected in parallel to the capacitor.

Abstract translation: 本发明涉及光谱仪器工程，并用于激发光谱分析光谱。 本发明的目的是开发一种用于具有高性能和高放电电流稳定性的交替和恒定电压的小型多用途电弧光谱激发源，这使得可以将电弧电流的所需值设置在 开始。 本发明的电弧放电发生器包括电源电路，用于形成具有开关晶体管的电弧电流的电路，设置有与其连接的运算放大器的电流响应电阻，设置有与其连接的电极的LC电路，用于形成高电平的单元 电压起弧脉冲和控制单元。 用于形成电弧电流的电路包括多电平比较器和专用处理器，电容器和电感串联连接到电极。 所述多电平比较器通过运算放大器连接到电阻器和专用处理器，其计算电阻性压降的均方值。 一个附加的键与电容器并联连接。

公开(公告)号：WO2004038812A1

公开(公告)日：2004-05-06

申请号：PCT/US2003/033813

申请日：2003-10-23

Applicant: CENTER FOR SCIENCE & TECHNOLOGY COMMERCIALIZATION ,  OPEL, INC.

Inventor： TAYLOR, Geoff, W. ,  CAI, Jianhong

IPC: H01L31/072

CPC classification number: H01L29/66318 ,  H01L29/155 ,  H01L29/66462 ,  H01L29/802 ,  H03K17/79 ,  H03M1/667 ,  H03M1/74 ,  H03M1/808

Abstract: Various optoelectronic circuits and photonic digital-to-analog converters are realized with one or more heterojunction thyristor devices and supporting circuitry. Such optoelectronic circuits include optically-controlled and electrically-controlled sampling/switching devices and optical data receivers. The photonic digital-to-analog converters include converters that process a plurality of digital optical signals that synchronously encode digital information as well as converters that process a digital optical signal that serially encodes digital information.

Abstract translation: 各种光电子电路和光子数模转换器由一个或多个异质结晶闸管器件和支持电路实现。 这种光电子电路包括光控和电控采样/开关器件和光数据接收器。 光子数模转换器包括处理同步编码数字信息的多个数字光信号以及处理串行编码数字信息的数字光信号的转换器的转换器。

公开(公告)号：WO2003092047A2

公开(公告)日：2003-11-06

申请号：PCT/US2003/013183

申请日：2003-04-28

Applicant: THE UNIVERSITY OF CONNECTICUT CENTER OF SCIENCE & TECHNOLOGY COMMERCIALIZATION ,  TAYLOR, Geoff, W.

Inventor： TAYLOR, Geoff, W.

IPC: H01L

CPC classification number: H01L31/111 ,  B82Y20/00 ,  H01L27/14643 ,  H01L27/14658 ,  H01L27/14806 ,  H01L27/14843 ,  H01L27/1485 ,  H01L29/205 ,  H01L29/74 ,  H01L31/03046 ,  H01L31/035236 ,  H01L31/035263 ,  H01L31/115 ,  Y02E10/544

Abstract: An improved THz detection mechanism includes a heterojunction thyristor structure logically formed by an n-type quantum-well-base bipolar transistor and p-type quantum-wellbase bipolar transistor arranged vertically to share a common collector region. Antenna elements, which are adapted to receive electromagnetic radiation in a desired portion of the THz region, are electrically coupled (or integrally formed with) the p-channel injector electrodes of the heterojunction thyristor device such the that antenna elements are electrically connected to the p-type modulation doped quantum well interface of the device. THz radiation supplied by the antenna elements to the p-type quantum well interface increases electron temperature of a two-dimensional electron gas at the p-type modulation doped quantum well interface thereby producing a current resulting from thermionic emission over a potential barrier provided by said first-type modulation doped quantum well interface. This current flows over the p-type channel barrier to the n­type quantum well interface, thereby causing charge to accumulate in the n-type quantum well interface. The accumulated charge in the n-type quantum well interface is related to the intensity of the received THz radiation. The heterojunction-thyristor-based THz detector is suitable for many applications, including data communication applications and imaging applications.

Abstract translation: 改进的THz检测机构包括由n型量子阱基双极晶体管和p型量子阱基双极晶体管逻辑形成的异质结晶闸管结构，其垂直布置以共享公共集电极区域。 适于在THz区域的所需部分接收电磁辐射的天线元件与异质结晶闸管器件的p沟道注入器电极电耦合（或整体形成），使得天线元件电连接到p 型调制掺杂量子阱接口。 由天线元件向p型量子阱界面提供的太赫兹辐射增加了在p型调制掺杂量子阱界面处的二维电子气的电子温度，从而产生由所述电子势垒产生的电流， 第一类调制掺杂量子阱界面。 该电流流过p型沟道势垒到n型量子阱界面，从而使电荷累积在n型量子阱界面中。 n型量子阱界面中的累积电荷与接收的THz辐射的强度有关。 基于异质结晶闸管的THz检测器适用于许多应用，包括数据通信应用和成像应用。

公开(公告)号：WO2003079976A3

公开(公告)日：2003-10-02

申请号：PCT/US2003/007827

申请日：2003-03-14

Applicant: TECHNOLOGY COMMERCIALIZATION CORP. ,  KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

Inventor： KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

IPC: A61F13/00

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, especially for patients addicted to opioid-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

公开(公告)号：WO2003079976A2

公开(公告)日：2003-10-02

申请号：PCT/US2003/007827

申请日：2003-03-14

Applicant: TECHNOLOGY COMMERCIALIZATION CORP. ,  KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

Inventor： KRYLOV, Boris, Vladimirovich ,  SHCHEGOLEV, Boris, Fedorovich

IPC: A61K

CPC classification number: A61K31/35 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/0073

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, especially for patients addicted to opioid-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

Abstract translation: 具有镇静作用的物质在药学上可接受的载体中包含治疗有效量的γ-吡喃酮，例如科美酸，肉碱酸，螯合酸等。 当以每千克体重患者的5至200mg活性成分的日剂量施用时，该物质可用于治疗各种神经性疾病，例如失眠，焦虑，神经症，抑郁症以及戒断症状 药物成瘾患者，特别是对于以阿片样物质为主的药物上瘾的患者。 该物质可以以多种方式递送，包括口服，胃肠外，透皮和经粘膜给药的药物的全身给药。 对于吸毒成瘾患者，优选的给药方法包括皮下植入物，其在5至30天，优选13至20天的整个治疗期间以有效的每日速率持续释放活性成分。

公开(公告)号：WO2020061346A1

公开(公告)日：2020-03-26

申请号：PCT/US2019/051979

申请日：2019-09-19

Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： ZHU, Qiang ,  CHEN, Mingliang ,  WU, Min ,  WONG, Chau-Wai

IPC: G06N3/02 ,  G06N3/08 ,  G10L15/20 ,  G10L25/30

Abstract: Systems, methods, apparatuses, and computer program products for tracking weak signal traces under severe noise and/or distortions. A method may include tracking at least one candidate frequency trace from a time-frequency representation of a signal. The method may also include identifying a frequency trace of the signal based on tracking results. In addition, the method may include outputting an estimated frequency vector related to the frequency trace. Further, the tracking may be performed under a noisy condition environment.

公开(公告)号：WO2016154709A1

公开(公告)日：2016-10-06

申请号：PCT/CA2015/000204

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC) ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： BAX, Jeffrey ,  BARKER, Kevin ,  SHAN, Dandan ,  WARING, Christopher ,  FENSTER, Aaron

IPC: B65G9/00 ,  F16M11/12 ,  F16M13/00

CPC classification number: F16M13/02 ,  A61B8/44 ,  F16M11/08 ,  F16M11/2057 ,  F16M2200/044

Abstract: Disclosed is a counterbalance apparatus, and a method for counterbalancing using an apparatus, having a center of motion that is internal or external to the apparatus. The apparatus and method are adapted to support a payload, having a load vector applied in a direction of the vector or gravity, that is positioned distal to the center of motion. The apparatus includes a gimbal adapted to support the payload and allow for its rotational movement about the center of motion generating a load torque therefrom, and a resilient member adapted to engage the gimbal and supply a support torque to counterbalance the load torque. The method includes a step of supporting the payload with a gimbal adapted to allow rotational movement of the payload about the center of motion to generate a load torque therefrom, and a step of configuring a resilient member to engage the gimbal and supply a support torque to counterbalance the load torque.

Abstract translation: 公开了一种平衡装置，以及一种使用装置进行平衡的方法，其具有在装置内部或外部的运动中心。 所述装置和方法适于支持具有沿向量或重力方向施加的负载矢量的有效载荷，所述载荷矢量位于所述运动中心的远侧。 该装置包括适于支撑有效载荷并允许围绕运动中心的旋转运动从而产生负载扭矩的万向节，以及适于与万向架接合并提供支撑力矩以平衡负载转矩的弹性构件。 该方法包括一个支撑有效载荷的步骤，该万向架适于允许有效载荷围绕运动中心的旋转运动，从而产生负载扭矩，以及将弹性构件配置成与万向架接合并将支撑力矩提供给 平衡负载转矩。

公开(公告)号：WO2016112452A1

公开(公告)日：2016-07-21

申请号：PCT/CA2015/000023

申请日：2015-01-14

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC) ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： BAX, Jeffrey ,  SHAN, Dandan ,  WARING, Christopher ,  FENSTER, Aaron

IPC: B65G7/00 ,  A61B19/00 ,  B65G9/00 ,  F16M11/18 ,  F16M13/00

CPC classification number: F16M13/02 ,  B66C23/76 ,  F16M11/046 ,  F16M11/048 ,  F16M11/10 ,  F16M11/18 ,  F16M11/2092 ,  F16M11/38 ,  F16M11/42 ,  F16M2200/047 ,  F16M2200/048 ,  F16M2200/061

Abstract: A counterbalance apparatus for supporting a load is provided. The apparatus includes a base, a load bearing arm, a toggle linkage, and first and second resilient members for applying a force to the load bearing arm. The load bearing arm consists of a plurality of pivot points forming a parallelogram linkage, may project from the base at an attachment point and is adapted to support the load at a distal end. The toggle linkage may be pivotally connected to the base and moveable between a non-load bearing position and a load bearing position. The toggle linkage may also comprise an adjustment member positioned to define a distance relative to the attachment point. The first resilient member is adapted to apply a force to the load bearing arm and may have a first end connected to a first portion of the parallelogram linkage and a second end connected to the adjustment member; and the second resilient member is also adapted to apply a force to the load bearing arm and may have a first end connected to a second portion of the parallelogram linkage and a second end connected to the adjustment member. Movement of the toggle linkage from the non-load bearing position to the load bearing position engages the forces of the resilient members and movement of the adjustment member varies the distance to adjust a support vector adapted to counterbalance the load vector.

Abstract translation: 提供了一种用于支撑负载的平衡装置。 该装置包括底座，承载臂，肘​​杆联动装置，以及用于向承载臂施加力的第一和第二弹性构件。 承载臂由形成平行四边形连杆的多个枢转点组成，可在附接点处从基座突出并且适于在远端支撑负载。 肘节连杆机构可枢转地连接到基座并且可在非承重位置和承重位置之间移动。 肘节连杆机构还可以包括调节构件，其被定位成限定相对于附接点的距离。 第一弹性构件适于向承载臂施加力并且可以具有连接到平行四边形连杆的第一部分的第一端和连接到调节构件的第二端; 并且第二弹性构件还适于向承载臂施加力并且可以具有连接到平行四边形连杆的第二部分的第一端和连接到调节构件的第二端。 肘节联动装置从非承载位置到承载位置的运动接合弹性构件的力并且调节构件的移动改变距离以调整适于平衡负载矢量的支撑向量。