中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

174 records (took 0.035 seconds)

    Process for the preparation of 1,3-propanediol
    32.
    发明授权
    Process for the preparation of 1,3-propanediol 失效
    1,3-丙二醇制备方法

    公开(公告)号：US5364987A

    公开(公告)日：1994-11-15

    申请号：US86040

    申请日：1993-07-06

    Applicant: Thomas Haas ,  Dietrich Arntz

    Inventor： Thomas Haas ,  Dietrich Arntz

    IPC: C07C31/20 ,  C07C29/141 ,  C07C29/80 ,  C07C29/88 ,  C07C45/64

    CPC classification number: C07C29/80 ,  C07C29/141 ,  C07C45/64

    Abstract: 1,3-propanediol (PD) is obtained by hydration of acrolein to 3-hydroxypropionaldehyde (HPA) with subsequent catalytic hydrogenation; 3,3'-oxybis-1-propanol (OD) occurs as a yield-reducing by-product. Disclosed is a process which increases the 1,3-propanediol yield. The OD which is separated by distillation during treatment of the reaction mixture containing PD and OD is treated in aqueous solution at from 100 to 300.degree. C. with an acid solid catalyst, in particular an acid zeolite, and the reaction mixture from which the solid catalyst has been removed is returned into the treatment stage of the reaction mixture containing PD and OD.

    Abstract translation: 通过将丙烯醛水合成3-羟基丙醛（HPA）并随后进行催化氢化获得1,3-丙二醇（PD） 3,3'-氧基双-1-丙醇（OD）作为产率降低副产物发生。 公开了增加1,3-丙二醇产率的方法。 在含有PD和OD的反应混合物的处理期间通过蒸馏分离的OD在100-300℃的水溶液中用酸固体催化剂，特别是酸性沸石和固体的反应混合物处理 已经除去的催化剂返回到含有PD和OD的反应混合物的处理阶段。

    Process for the prepartion of 3-hydroxyalkanals
    33.
    发明授权
    Process for the prepartion of 3-hydroxyalkanals 失效
    3-羟基卡那酸的制备方法

    公开(公告)号：US5284979A

    公开(公告)日：1994-02-08

    申请号：US980955

    申请日：1992-11-24

    Applicant: Thomas Haas ,  Georg Bohme ,  Dietrich Arntz

    Inventor： Thomas Haas ,  Georg Bohme ,  Dietrich Arntz

    IPC: B01J31/04 ,  C07B61/00 ,  C07C29/141 ,  C07C31/20 ,  C07C45/64 ,  C07C47/19 ,  C07C45/61

    CPC classification number: C07C29/141 ,  C07C45/64

    Abstract: A process is disclosed for the preparation of 3-hydroxyalkanals having 3 to 12 carbon atoms, in particular 3 or 4 carbon atoms, by hydration of the underlying 2-alkenals with water in a homogeneous phase in the presence of an acid catalyst. The previously known hydration using mineral acids or carboxylic acids as catalyst results in low volume/time yields and/or low selectivities. These disadvantages can be avoided by using in the present invention, as catalyst, a dissolved acid-base buffer which results in a pH of from 2 to 5 in the reaction mixture; the acid component and corresponding base of which are present in a total quantity of from 0.5 to 40% by weight in the reaction mixture. The preferred buffers composed of a lower monobasic carboxylic acid and a tertiary amine can easily be recycled.

    Abstract translation: 公开了制备具有3-12个碳原子，特别是3或4个碳原子的3-羟基卡那醇的方法，通过在酸催化剂存在下，使水相在均相上与下面的2-烯烃水合。 使用无机酸或羧酸作为催化剂的先前已知的水合导致低体积/时间产率和/或低选择性。 通过在本发明中使用在反应混合物中导致pH为2至5的溶解的酸碱缓冲液作为催化剂，可以避免这些缺点。 酸组分和其相应的碱在反应混合物中的总量为0.5-40重量％。 由较低一元羧酸和叔胺组成的优选缓冲液可以容易地再循环。

    Process for the improved separation of a hydrophobic organic solution from an aqueous culture medium
    37.
    发明授权
    Process for the improved separation of a hydrophobic organic solution from an aqueous culture medium 有权
    改进疏水性有机溶液与水性培养基分离的方法

    公开(公告)号：US09249435B2

    公开(公告)日：2016-02-02

    申请号：US13721481

    申请日：2012-12-20

    Applicant: Jasmin Gielen ,  Thomas Haas ,  Hans-Georg Hennemann ,  Steffen Schaffer ,  Mirja Wessel ,  Katharina Berse ,  Marion Schiebelhut ,  Sabine Hafkemeyer ,  Markus Poetter ,  Frank Erhardt

    Inventor： Jasmin Gielen ,  Thomas Haas ,  Hans-Georg Hennemann ,  Steffen Schaffer ,  Mirja Wessel ,  Katharina Berse ,  Marion Schiebelhut ,  Sabine Hafkemeyer ,  Markus Poetter ,  Frank Erhardt

    IPC: C12P13/04 ,  C12P7/64 ,  C12N9/02

    CPC classification number: C12P7/6436 ,  C12N9/001 ,  C12P13/04 ,  C12Y103/99003

    Abstract: A process for the improved separation of a hydrophobic organic solution from an aqueous culture medium is provided. The process includes preparing an aqueous culture medium of a metabolically active cell having a decreased activity; contacting of the aqueous culture medium with a hydrophobic organic solution comprising a substrate for biotransformation; conducting a biotransformation of the substrate; and separating the hydrophobic organic solution comprising a biotransformed substrate from the aqueous culture medium. The decreased activity of the metabolically active cell is in comparison to a wild-type of the active cell and the decreased activity is of at least of one enzyme that catalyzes one reaction of β-oxidation of fatty acids. The invention further provides a metabolically active cell that has a decreased activity, compared to its wild-type, of an enzyme that catalyzes one of the reactions of the β-oxidation of fatty acids, including an enzyme selected from FadA, FadB, FadD, FadL and FadE as well as variants thereof.

    Abstract translation: 提供了一种从水性培养基中改善疏水性有机溶液分离的方法。 该方法包括制备活性降低的代谢活性细胞的水性培养基; 使含水培养基与包含用于生物转化的底物的疏水性有机溶液接触; 进行基底的生物转化; 并从含水培养基中分离包含生物转化底物的疏水性有机溶液。 与野生型活性细胞相比，代谢活性细胞的活性降低，活性降低至少是催化脂肪酸一次反应的一种酶。 本发明进一步提供了一种代谢活性细胞，其与野生型相比具有降低的活性，其酶催化脂肪酸的一种反应的反应，包括选自FadA，FadB，FadD的酶 ，FadL和FadE及其变体。

    PROCESS FOR PREPARING AN ALPHA, OMEGA-ALKANEDIOL
    38.
    发明申请
    PROCESS FOR PREPARING AN ALPHA, OMEGA-ALKANEDIOL 审中-公开
    制备ALPHA，OMEGA-ALKANEDIOL的方法

    公开(公告)号：US20150353963A1

    公开(公告)日：2015-12-10

    申请号：US14763378

    申请日：2014-01-10

    Applicant: Thomas HAAS ,  Philip ENGEL ,  Jan Christoph PFEFFER ,  Oliver THUM ,  Christian GEHRING

    Inventor： Thomas HAAS ,  Phillip ENGEL ,  Jan Christoph PFEFFER ,  Oliver THUM ,  Christian GEHRING

    IPC: C12P7/18 ,  C07C29/136 ,  C07C67/08

    CPC classification number: C12P7/18 ,  C07C29/136 ,  C07C67/08 ,  C12P7/62 ,  C12Y114/15003

    Abstract: The invention relates to a process for preparing an α,ω-alkanediol comprising the steps of a) reacting an alkanoic acid with an alkanol to give an ester, b) oxidizing at least one terminal carbon atom of the ester by contacting with a whole-cell catalyst, which expresses an alkane hydroxylase, in aqueous solution and in the presence of molecular oxygen, to give an oxidized ester, c) hydrogenating the oxidized ester to form the alkanediol and alkanol, and d) removing the alkanol by distillation, forming a reaction mixture depleted with respect to the alkanol, and recycling the alkanol in step b).

    Abstract translation: 本发明涉及一种制备α，ω-链烷二醇的方法，包括以下步骤：a）使链烷酸与链烷醇反应得到酯，b）通过与全烷基酯接触来氧化酯的至少一个末端碳原子， 在水溶液中和在分子氧存在下表达烷烃羟化酶的细胞催化剂，得到氧化的酯，c）氢化氧化的酯以形成链烷二醇和链烷醇，和d）通过蒸馏除去烷醇，形成 反应混合物相对于烷醇消耗，并在步骤b）中回收链烷醇。

Patent Agency Ranking