公开(公告)号：US12226950B2

公开(公告)日：2025-02-18

申请号：US18315266

申请日：2023-05-10

Applicant: UNIVERSITEIT TWENTE

Inventor： Claas Willem Visser ,  Dahlia Ningrum Amato ,  Jennifer A. Lewis ,  Jochen Mueller

IPC: B29C64/112 ,  B29C64/188 ,  B29C64/209 ,  B29C64/236 ,  B29C64/245 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B29K105/00 ,  B29K105/04 ,  B29K105/16

Abstract: A method of printing a cellular solid by direct bubble writing comprises introducing an ink formulation comprising a polymerizable monomer and a gas into a nozzle, which includes a core flow channel radially surrounded by an outer flow channel. The ink formulation is directed into the outer flow channel and the gas is directed into the core flow channel. The ink formulation and the gas are ejected out of the nozzle as a stream of bubbles, where each bubble includes a core comprising the gas and a liquid shell overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell from the liquid shell, and the bubbles are deposited on a substrate moving relative to the nozzle. Thus, a polymeric cellular solid having a predetermined geometry is printed.

公开(公告)号：US20240360339A1

公开(公告)日：2024-10-31

申请号：US18553313

申请日：2022-03-21

Applicant: MICRONIT HOLDING B.V. ,  UNIVERSITEIT TWENTE

Inventor： Jurriaan HÜSKENS ,  Daniele DI IORIO ,  Maciej Damian SKOLIMOWSKI ,  Brigitte Bibiche Bruijns

IPC: C09J5/02 ,  B01L3/00 ,  B32B7/12 ,  B32B27/08 ,  B32B27/32 ,  B32B37/12

CPC classification number: C09J5/02 ,  B01L3/502707 ,  B01L3/502761 ,  B32B7/12 ,  B32B27/08 ,  B32B27/325 ,  B32B37/12 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/16 ,  B32B2250/02 ,  B32B2250/242 ,  B32B2255/10 ,  B32B2255/26 ,  C09J2423/008 ,  C09J2477/00

Abstract: A method for forming a bond between substrates of a device includes providing first and second substrates, providing a first functionalized polyelectrolyte polymer (A) and providing a second functionalized polyelectrolyte polymer (B). Forming a functionalized surface on an exposed surface of the first substrate having the first functionalized polyelectrolyte polymer (A) attached thereto, forming a functionalized surface on an exposed surface of the second substrate having the second functionalized polyelectrolyte polymer (B) attached thereto, contacting at least a part of the functionalized surface of the first substrate onto at least a part of the functionalized surface of the second substrate thereby forming a contact area between the first functionalized polyelectrolyte polymer (A) and the second functionalized polyelectrolyte polymer (B), and forming a covalent bond between a first coupling moiety (A1) and a second coupling moiety (B1) in the contact area between the first and second substrates for binding the substrates.

公开(公告)号：US20240008757A1

公开(公告)日：2024-01-11

申请号：US18272993

申请日：2022-01-14

Applicant: UNIVERSITEIT TWENTE

Inventor： Wiendelt STEENBERGEN ,  Ata CHIZARI ,  Tom KNOP

IPC: A61B5/026

CPC classification number: A61B5/0261

Abstract: Disclosed is a handheld laser-based perfusion imaging apparatus having a light source and an imaging device which are arranged in a fixed orientation to each other in the apparatus. The light source is configured for projecting a beam of coherent light onto a measurement field at a predetermined distance spaced apart from the apparatus. The imaging device is configured for recording speckle intensity maps of the measurement field and/or images of Doppler shifted light of the measurement field. The light source is configured to provide a substantially spherical wavefront or a substantial planar wavefront, at least at the measurement field. Preferably, the apparatus with the light source that provides a substantial planar wavefront, including a gimbal mount. Also disclosed is a method for measuring a perfusion in a tissue using the handheld laser-based perfusion imaging apparatus as described above.

公开(公告)号：US20230330377A1

公开(公告)日：2023-10-19

申请号：US18028947

申请日：2021-09-27

Applicant: UNIVERSITEIT TWENTE

Inventor： Rob HAGMEIJER ,  Rutger Hendrik Johan HEBBINK

IPC: A61M16/06

CPC classification number: A61M16/0672 ,  A61M2016/0027

Abstract: A method for monitoring a system for injecting heated air into a patient. The system includes a source of air, a device for heating the air, a cannula for insertion into nostrils of the patient, a first conduit interconnecting the source and the device, and a second conduit interconnecting the device and the cannula. The method includes deriving pressure in the cannula from pressure of the air between the source and the cannula. The method includes measuring a pressure of the air at between the source and the cannula, determining a flow rate of the air in the system, deriving a first function representative of a respiratory flow rate of the patient from the measured pressure and the system air flow rate, deriving a second function representative of a respiratory volume of the patient from the measured pressure and the system air flow rate, and graphically displaying the functions.

公开(公告)号：US20230250383A1

公开(公告)日：2023-08-10

申请号：US18003195

申请日：2021-06-30

Applicant: Universiteit Twente ,  Ente Ospedaliero Specializzato in Gastroenterologia "Saverio De Bellis" - IRCCS

Inventor： Arturo Susarrey Arce ,  Silke Inge Krol ,  Johan Willem Berenschot ,  Niels Roelof Tas

IPC: C12M1/12 ,  C12N5/00 ,  C12M3/00

CPC classification number: C12M25/14 ,  C12N5/0062 ,  C12N5/0068 ,  C12M21/08 ,  C12N2513/00

Abstract: The disclosure relates to a method for producing three-dimensional cell cluster on an inorganic cell culture platform comprising three-dimensional structures, preferably fractal structures. Such three-dimensional structures are useful for culturing cells and tissues, preferably in three dimensions. Such three-dimensional structures are useful for inducing differentiation, preferably of non-embryonic stem cells. In particular, such three-dimensional (3D) structures are useful for culturing primary tissue cells.

公开(公告)号：US11629048B2

公开(公告)日：2023-04-18

申请号：US16647252

申请日：2018-09-17

Applicant: BERKIN B.V. ,  UNIVERSITEIT TWENTE ,  STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN

Inventor： Yiyuan Zhao ,  Henk-Willem Veltkamp ,  Yaxiang Zeng ,  Joost Conrad Lötters ,  Remco John Wiegerink

IPC: B81C1/00

Abstract: The invention relates to a method of fabricating a micro machined channel, comprising the steps of providing a substrate of a first material and having a buried layer of a different material therein, and forming at least two trenches in said substrate by removing at least part of said substrate. Said trenches are provided at a distance from each other and at least partly extend substantially parallel to each other, as well as towards said buried layer. The method comprises the step of forming at least two filled trenches by providing a second material different from said first material and filling said at least two trenches with at least said second material; forming an elongated cavity in between said filled trenches by removing at least part of said substrate extending between said filled trenches; and forming an enclosed channel by providing a layer of material in said cavity and enclosing said cavity.

公开(公告)号：US20220153028A1

公开(公告)日：2022-05-19

申请号：US17436691

申请日：2020-03-06

Applicant: UNIVERSITEIT TWENTE

Inventor： David Fernandez RIVAS ,  Loreto Alejandra Oyarte GALVEZ

IPC: B41J2/14 ,  A61M5/30 ,  B01L3/00

Abstract: A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: —the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5-400 μm, a chamber width we selected from the range of 2hc-10hc, and a chamber length lc defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); —the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).

公开(公告)号：US20220099663A1

公开(公告)日：2022-03-31

申请号：US17434110

申请日：2020-03-05

Applicant: UNIVERSITEIT TWENTE

Inventor： Dilu George MATHEW ,  Pepijn BEEKMAN ,  Wilfred Gerard VAN DER WIEL ,  Serge Joseph Guy LEMAY

IPC: G01N33/543 ,  G01N33/574 ,  G01N27/49

Abstract: The invention provides a sensor (100) for sensing a predetermined particle (10) in a fluid (11), wherein the sensor (100) comprises (i) an electrode (110) and (ii) an recognition element (112), wherein the electrode (110) comprises an electrode face (111) configured accessible to the fluid (11), to the predetermined particle (10) in the fluid (11), and to a redox mediator (12) in the fluid (11); and wherein the recognition element (112) is configured to at least temporarily selectively bind with the predetermined particle (10), thereby limiting access of the redox mediator (12) to the electrode face (111) during the binding of the predetermined particle with the recognition element (112).

公开(公告)号：US20220002508A1

公开(公告)日：2022-01-06

申请号：US17291289

申请日：2018-11-07

Applicant: Universiteit Twente

Inventor： Wiebe Matthijs de Vos ,  Joshua David Willot ,  Wouter Martinus Nielen

IPC: C08J5/18 ,  C08J9/14 ,  B01D67/00 ,  B01D69/12 ,  B01D71/76 ,  B01D69/08

Abstract: The invention relates to a method for creating a porous film through aqueous phase separation, the method comprising: i) providing an aqueous solution comprising a responsive copolymer, and optionally a charged polymer, wherein at least one of the monomers in the responsive copolymer is a responsive monomer; ii) forming the aqueous solution into a thin layer and contacting the thin layer of aqueous solution with an aqueous coagulation solution in which the responsive copolymer is not soluble, or contacting the thin layer of aqueous solution with an aqueous coagulation solution in which a complex comprising the responsive copolymer and the charged polymer is not soluble; and iii) allowing solvent exchange between the aqueous solution and the aqueous coagulation solution to produce a porous film. The invention further relates to porous films or membranes thus obtained.

公开(公告)号：US11212120B2

公开(公告)日：2021-12-28

申请号：US16206344

申请日：2018-11-30

Applicant: SCHOTT AG ,  UNIVERSITEIT TWENTE

Inventor： Mark J. Davis ,  Martin Letz ,  Allard Mosk ,  Pepijn Pinkse

IPC: H04L29/06 ,  H04L9/32 ,  H04L9/08 ,  G09C5/00 ,  G06F7/58

Abstract: An apparatus for authenticating an optical key and an apparatus for generating a random number from an optical key are provided. The optical key is used for reliable authenticatability and the random number is stable when or after the optical key is exposed to an external influence such as, but not limited to, a physical or chemical stimulus including a different ambient condition, a mechanical stress, or chemical contact.