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公开(公告)号：US09126940B2
公开(公告)日：2015-09-08
申请号：US14180939
申请日：2014-02-14
Applicant: VentiRx Pharmaceuticals, Inc. , Array BioPharma, Inc.
Inventor： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong-Woon Yang
IPC: A01N43/00 , A61K31/55 , C07D223/16 , C07D223/14 , C07D401/12 , C07D401/14 , C07D403/10 , C07D401/04 , C07D405/04 , C07D405/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：WO2012045090A3
公开(公告)日：2012-07-19
申请号：PCT/US2011054654
申请日：2011-10-03
Applicant: VENTIRX PHARMACEUTICALS INC , HERSHBERG ROBERT , COUKOS GEORGE , DIETSCH GREGORY , FACCIABENE ANDREA , MANJARREZ KRISTI , RANDALL TRESSA D
Inventor： HERSHBERG ROBERT , COUKOS GEORGE , DIETSCH GREGORY , FACCIABENE ANDREA , MANJARREZ KRISTI , RANDALL TRESSA D
IPC: A61K31/55 , A61K9/127 , A61K9/48 , A61K31/122 , A61P35/00
CPC classification number: A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
Abstract: The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
Abstract translation: 本发明总体上涉及TLR激动剂（优选TLR8激动剂）的制剂，及其在治疗各种疾病（包括用于治疗癌症的联合疗法）中的用途。
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公开(公告)号：WO2012045090A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/054654
申请日：2011-10-03
Applicant: VENTIRX PHARMACEUTICALS, INC. , HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa, D.
Inventor： HERSHBERG, Robert , COUKOS, George , DIETSCH, Gregory , FACCIABENE, Andrea , MANJARREZ, Kristi , RANDALL, Tressa, D.
IPC: A61K31/55 , A61K31/122 , A61K9/127 , A61K9/48 , A61P35/00
CPC classification number: A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
Abstract: The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
Abstract translation: 本发明一般涉及TLR激动剂优选TLR8激动剂的制剂及其在治疗各种疾病中的用途，包括用于治疗癌症的组合疗法。
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公开(公告)号：WO2011022508A2
公开(公告)日：2011-02-24
申请号：PCT/US2010045934
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：WO2012097177A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/021116
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC. , HOWBERT, James, Jeffry , HERSHBERG, Robert
Inventor： HOWBERT, James, Jeffry , HERSHBERG, Robert
IPC: C07D403/10 , C07D403/12 , C07D223/14 , A61K31/55 , A61P37/00
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
Abstract translation: 提供可用于调节通过Toll样受体TLR7和/或TLR8的信号传导的组合物和方法。 该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，传染病，炎症性疾病，移植排斥或移植物抗宿主病。
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Patent Agency Ranking
公开(公告)号：WO2012045089A3
公开(公告)日：2012-07-19
申请号：PCT/US2011054652
申请日：2011-10-03
Applicant: VENTIRX PHARMACEUTICALS INC , HERSHBERG ROBERT
Inventor： HERSHBERG ROBERT
CPC classification number: A61K31/55 , A61K9/0043
Abstract: The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.
Abstract translation: 本发明一般涉及TLR8激动剂VTX-378，用于治疗或预防过敏性疾病，包括过敏性鼻炎。
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公开(公告)号：WO2010014913A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052422
申请日：2009-07-31
Applicant: VENTIRX PHARMACEUTICALS, INC. , HOWBERT, J., Jeffry , DUVVURI, Muralikrishna , HERSHBERG, Rob , DIETSCH, Greg
Inventor： HOWBERT, J., Jeffry , DUVVURI, Muralikrishna , HERSHBERG, Rob , DIETSCH, Greg
IPC: A61K39/395
CPC classification number: A61K31/55 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/724 , A61K47/40 , A61K47/48969 , A61K47/6951 , B82Y5/00 , C07D223/16 , C08B37/0012 , Y02A50/393
Abstract: The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonist which comprise a cyclodextrin.
Abstract translation: 本发明总体上涉及用于治疗癌症，优选实体瘤和淋巴瘤的TLR激动剂（优选TLR7或TLR8激动剂）的稳定制剂。 具体而言，本发明涉及包含环糊精的至多50mg / ml的TLR激动剂的稳定制剂。
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公开(公告)号：WO2017079283A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060098
申请日：2016-11-02
Applicant: VENTIRX PHARMACEUTICALS, INC.
Inventor： DIETSCH, Gregory N.
IPC: A61K31/55 , A61K39/395 , A61K31/704
CPC classification number: A61K31/55 , A61K31/704 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/2863 , C07K2317/24 , C07K2317/732 , C07K2317/76 , A61K2300/00
Abstract: The application relates to methods of inducing antitumor immune responses in a subject having cancer. In some embodiments, methods are provided for administering to a subject in need thereof a TLR8 agonist and a PD1-1/PD-L1 antagonist, optionally including one or more additional therapeutic agents.
Abstract translation: 本申请涉及在患有癌症的受试者中诱导抗肿瘤免疫应答的方法。 在一些实施方案中，提供了用于向有需要的受试者施用TLR8激动剂和PD1-1 / PD-L1拮抗剂的方法，任选地包括一种或多种其他治疗剂。
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公开(公告)号：WO2012097177A3
公开(公告)日：2012-10-26
申请号：PCT/US2012021116
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , HERSHBERG ROBERT
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT
IPC: C07D403/10 , A61K31/55 , A61P37/00 , C07D223/14 , C07D403/12
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。
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公开(公告)号：WO2011022509A3
公开(公告)日：2011-06-16
申请号：PCT/US2010045935
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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