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公开(公告)号：EP1981851A1
公开(公告)日：2008-10-22
申请号：EP07762713.1
申请日：2007-01-26
Applicant: Array Biopharma, Inc. , Groneberg, Robert , Burgess, Laurence E. , Harvey, Darren , Laird, Ellen , Munson, Mark , Rizzi, James , Rodriguez, Martha , Eary, Charles Todd , Watson, Daniel
Inventor： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC: C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC classification number: C07D231/40 , C07D231/56
Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
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公开(公告)号：WO2009158426A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048499
申请日：2009-06-24
Applicant: ARRAY BIOPHARMA INC. , BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd
Inventor： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd
IPC: C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00
CPC classification number: C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
Abstract: Compounds of Formula (I): in which A 1 , A 2 , W, L, G, R 7a , R 7b , R 8 , R 9 and R 10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
Abstract translation: 式（I）化合物：其中A1，A2，W，L，G，R7a，R7b，R8，R9和R10具有本说明书中给出的含义，是可用于治疗免疫疾病的DP2受体调节剂。
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3.发明申请
公开(公告)号：WO2006023452A3
公开(公告)日：2006-03-02
申请号：PCT/US2005/029003
申请日：2005-08-15
Applicant: ARRAY BIOPHARMA INC. , HUNT, Kevin, W. , BURGESS, Laurence, E.
Inventor： HUNT, Kevin, W. , BURGESS, Laurence, E.
Abstract: Provided are novel cyclosporin analogs, methods for their production, and their use for treating immunoregulatory and respiratory diseases, disorders, and conditions.
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公开(公告)号：WO2011022508A2
公开(公告)日：2011-02-24
申请号：PCT/US2010045934
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：WO2007089646A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/002272
申请日：2007-01-26
Applicant: ARRAY BIOPHARMA INC. , GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
Inventor： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC: C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC classification number: C07D231/40 , C07D231/56
Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
Abstract translation: 式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。
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Patent Agency Ranking6.发明申请CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES 审中-公开用于治疗免疫缺陷性疾病和呼吸道疾病的环磷酰胺类似物
公开(公告)号：WO2006023452A2
公开(公告)日：2006-03-02
申请号：PCT/US2005029003
申请日：2005-08-15
Applicant: ARRAY BIOPHARMA INC , HUNT KEVIN W , BURGESS LAURENCE E
Inventor： HUNT KEVIN W , BURGESS LAURENCE E
CPC classification number: A61K38/13 , A61K47/54 , A61K47/545 , C07K7/645
Abstract: Provided are novel cyclosporin analogs, methods for their production, and their use for treating immunoregulatory and respiratory diseases, disorders, and conditions.
Abstract translation: 提供新的环孢菌素类似物，其生产方法及其用于治疗免疫调节和呼吸系统疾病，病症和病症的用途。
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公开(公告)号：WO1994012505A1
公开(公告)日：1994-06-09
申请号：PCT/US1993008613
申请日：1993-09-17
Applicant: PFIZER INC. , BURGESS, Laurence, E. , SCHULTE, Gary, R.
Inventor： PFIZER INC.
IPC: C07F07/08
CPC classification number: C07D409/06 , C07D333/38 , C07F7/0803
Abstract: 4-Chloro-2-thiophenecarboxylic acid is made by forming a compound of formula (Ia), wherein R is (C1-C6) alkyl, phenyl, or benzyl; converting the compound to a compound of formula (IVa); and removing the silyl group R3Si-. The product is useful as an intermediate in making pharmaceutical products.
Abstract translation: 通过形成其中R 3为（C 1 -C 6）烷基，苯基或苄基的式（Ia）化合物制备4-氯-2-噻吩羧酸。 将化合物转化为式（Ⅳa）化合物; 并除去甲硅烷基R3Si-。 该产品作为制造药品的中间体是有用的。
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公开(公告)号：WO2011022509A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/045935
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC , HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , DOHERTY, George, A. , EARY, C. Todd , GRONEBERG, Robert, D. , JONES, Zachary
Inventor： HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , DOHERTY, George, A. , EARY, C. Todd , GRONEBERG, Robert, D. , JONES, Zachary
IPC: C07D403/10 , C07D403/14 , C07D401/14 , C07D223/14 , A61K31/4025 , A61K31/55 , A61P35/00 , A61P31/00
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供用于调节通过Toll样受体TLR7和/或TLR8的信号传导的组合物和方法。 该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎症性疾病，移植排斥反应和移植物抗宿主疾病。
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公开(公告)号：WO2007126871A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/007658
申请日：2007-03-27
Applicant: ARRAY BIOPHARMA INC. , MUNSON, Mark , HUNT, Kevin, W. , CLARK, Christopher, T. , KIM, Ganghyeok , BURGESS, Laurence, E. , RIZZI, James
Inventor： MUNSON, Mark , HUNT, Kevin, W. , CLARK, Christopher, T. , KIM, Ganghyeok , BURGESS, Laurence, E. , RIZZI, James
IPC: C07D403/12 , C07D401/12 , A61K31/416 , A61P29/00
CPC classification number: C07D403/12 , C07D401/12
Abstract: Compounds of formula (I): in which A, B, X, Ar 1 , R 8 and R 4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.
Abstract translation: 式（I）化合物：其中A，B，X，Ar 1，R 8和R 4具有给定的任何含义 在说明书中是p38的抑制剂，其可用于治疗和预防由p38介导的各种疾病。
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公开(公告)号：WO2013055645A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059282
申请日：2012-10-09
Applicant: ARRAY BIOPHARMA INC. , BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
Inventor： BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
CPC classification number: C07D487/04
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Abstract translation: R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有本说明书中给出的含义的式I化合物及其立体异构体及其药学上可接受的盐和溶剂合物是一种或多种JAK激酶的抑制剂，并且是有用的 治疗自身免疫性疾病，炎症性疾病，移植器官，组织和细胞排斥，以及血液系统疾病和恶性肿瘤及其并发症。
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