그렘린-1에 대한 항체
    34.
    发明公开
    그렘린-1에 대한 항체 审中-实审
    反对GREMLIN-1的抗体

    公开(公告)号:KR1020130105541A

    公开(公告)日:2013-09-25

    申请号:KR1020130028123

    申请日:2013-03-15

    Abstract: PURPOSE: An antibody against gremlin-1 is provided to suppress cell migration, cell invasion, and cell proliferation depending on gremlin-1, thereby treating cancer or immune diseases. CONSTITUTION: An antibody against gremlin-1 is provided. The antibody has anticancer effect by suppressing gremlin-1 in a bone morphogenetic protein (BMP) or vascular endothelial growth factor receptor-2 (VEGFR2) independent mode. The antibody is selected among an immune antibody, a chimera antibody, a human antibody, and a humanized antibody. Gremlin-1 is directly conjugated to cancer cells by the antibody.

    Abstract translation: 目的:提供一种针对gremlin-1的抗体,以根据gremlin-1抑制细胞迁移,细胞侵袭和细胞增殖,从而治疗癌症或免疫疾病。 构成:提供了针对gremlin-1的抗体。 该抗体通过抑制骨形态发生蛋白(BMP)或血管内皮生长因子受体-2(VEGFR2)独立模式中的gremlin-1具有抗癌作用。 抗体选自免疫抗体,嵌合体抗体,人抗体和人源化抗体。 Gremlin-1通过抗体直接与癌细胞结合。

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