公开(公告)号：KR1020120140450A

公开(公告)日：2012-12-31

申请号：KR1020110060194

申请日：2011-06-21

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  노민수 ,  박수남

IPC: A61K36/62 ,  C12N5/0775 ,  A61P17/00

CPC classification number: A61K36/62 ,  A61Q90/00 ,  C12N5/0662 ,  C12N5/0669

Abstract: PURPOSE: A composition with Nelumbinis Semen extracts as an active ingredient for promoting the differentiation of adipocyte in human mesenchymal stem cell is provided to promote differentiating the adipocyte from a human mesenchymal stem cell to produce lipid droplet, enhance the electricity and the volume of skin and reduce wrinkles. CONSTITUTION: A composition for skin external application for promoting the differentiation of adipocyte contains Nelumbinis Semen extracts as an active ingredient. The composition promotes differentiating adipocyte from a mesenchymal stem cell. The mesenchymal stem cell is a human mesenchymal cell. The composition increases adipocyte tissue. For the total weight of the composition, a Nelumbinis Semen extract weighs ranging from 0.001 to 30%. The composition enhances the volume of skin and the elasticity of skin, and reduces skin wrinkles. A pharmaceutical composition for promoting the differentiation of a adipocyte cell contains Nelumbinis Semen as an active ingredient. A Nelumbinis Semen extract is administered from 0.001mg /kg /day-2000mg /kg /day. [Reference numerals] (AA) Relative revelation amount; (BB) Negative control group; (CC) Ligustri Fructus; (DD) Veratri Rhizoma Et Radix; (EE) Forsythiae Fructus; (FF) Nelumbo semen

Abstract translation: 目的：提供具有Nelumbinis Semen提取物作为促进人间充质干细胞中脂肪细胞分化的活性成分的组合物，以促进脂肪细胞与人间充质干细胞的分化，产生脂滴，增强皮肤的电力和体积， 减少皱纹。 构成：用于促进脂肪细胞分化的皮肤外用应用组合物含有Nelumbinis Semen提取物作为活性成分。 该组合物促进脂肪细胞与间充质干细胞分化。 间充质干细胞是人类间充质细胞。 组合物增加脂肪细胞组织。 对于组合物的总重量，Nelumbinis Semen提取物的重量范围为0.001至30％。 该组合物增强皮肤的体积和皮肤的弹性，并减少皮肤皱纹。 用于促进脂肪细胞分化的药物组合物含有Nelumbinis Semen作为活性成分。 Nelumbinis精液提取物以0.001mg / kg /天-2000mg / kg /天施用。 （附图标记）（AA）相对启示量; （BB）阴性对照组; （CC）Ligustri Fructus; （DD）Veratri Rhizoma Et Radix; （EE）连翘; （FF）Nelumbo精液

公开(公告)号：KR1020120088896A

公开(公告)日：2012-08-09

申请号：KR1020100115854

申请日：2010-11-19

Applicant: (주)아모레퍼시픽

Inventor： 최현 ,  김윤경 ,  김규한 ,  이태룡 ,  노민수 ,  신동욱

IPC: C12N15/113 ,  C12N5/071 ,  A61K31/7105 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K31/7105 ,  C12N5/0625 ,  C12Q1/68 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: PURPOSE: A composition containing miRNA molecule or mimic of DUOX2 for controlling skin cell differentiation is provided to regulate DUOX2, filagrin, loricrin, keratin 1, and keratin 10 genes. CONSTITUTION: A composition for controlling skin cell differentiation contains miRNA molecule or mimic of DUOX2 having 7-25 bases with a base sequence of sequence number 1. The miRNA molecule or mimic targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition promotes skin cell differentiation. A miRNA inhibitor of DUOX2 targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition suppresses skin cell differentiation. The skin cell is keratinocytes.

Abstract translation: 目的：提供含有miRNA分子或模拟DUOX2用于控制皮肤细胞分化的组合物，用于调节DUOX2，丝胶蛋白，氯氰菊酯，角蛋白1和角蛋白10基因。 构成：用于控制皮肤细胞分化的组合物包含miRNA分子或具有7-25个碱基的DUOX2的模拟物，其碱基序列为序列号1. miRNA分子或模拟物靶向DUOX2 mRNA 3'-UTR的第1358至第1364位核酸。 该组合物促进皮肤细胞分化。 DUOX2的miRNA抑制剂靶向DUOX2 mRNA 3'-UTR的1358至1364位核酸。 该组合物抑制皮肤细胞分化。 皮肤细胞是角质细胞。

公开(公告)号：KR1020120061007A

公开(公告)日：2012-06-12

申请号：KR1020100108114

申请日：2010-11-02

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  김윤경

IPC: A61K36/237 ,  A61K8/97 ,  A61K8/06 ,  A61K9/06 ,  A61Q19/08

CPC classification number: A61K36/237 ,  A61K8/06 ,  A61K8/97 ,  A61K9/06 ,  A61K2236/33 ,  A61Q19/08

Abstract: PURPOSE: A composition for promoting differentiation of human mesenchymal stem cells into adipocytes is provided to enhance the volume and elasticity on the skin. CONSTITUTION: An external use skin composition for promoting differentiation of mesenchymal stem cells into adipocytes contains 0.0001-30 wt% of Angelicae koreanae Radix extract as an active ingredient. The mesenchymal stem cells are human mesenchymal stem cells. A pharmaceutical composition for promoting differentiation into adipocytes contains the Angelicae koreanae Radix extract as an active ingredient.

Abstract translation: 目的：提供用于促进人间充质干细胞分化为脂肪细胞的组合物，以增强皮肤的体积和弹性。 构成：用于促进间充质干细胞分化为脂肪细胞的外用皮肤组合物含有0.0001-30重量％的当归白芷提取物作为活性成分。 间充质干细胞是人间充质干细胞。 用于促进脂肪细胞分化的药物组合物含有当归白芷提取物作为活性成分。

公开(公告)号：KR1020120058866A

公开(公告)日：2012-06-08

申请号：KR1020100120373

申请日：2010-11-30

Applicant: (주)아모레퍼시픽

Inventor： 심중현 ,  김지현 ,  심종원 ,  민대진 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

IPC: A61K38/06 ,  A61K31/728 ,  A61K35/12 ,  A61K8/64 ,  A61Q19/08

CPC classification number: A61K38/06 ,  A61K8/64 ,  A61K31/728 ,  A61K35/12 ,  A61Q19/08

Abstract: PURPOSE: A composition containing tripeptides, low molecular hyaluronic acid, mineral, and vitamin is provided to enhance stemness of adipose-derived stem cells. CONSTITUTION: A composition for enhancing stemness of adipose-derived stem cells contains 0.001-3 wt% of tripeptide of glycine-proline-hydroxyproline(Gly-Pro-Hyp), 0.01-50 wt% of low molecular hyaluronic acid, 0.001-3 wt% of mineral, and 0.001-3 wt% of vitamin as active ingredients. The composition is designed from ECM(extracellular matrix). The stem cell is human adipose derived stem cells(hADSCs).

Abstract translation: 目的：提供含有三肽，低分子透明质酸，矿物质和维生素的组合物，以增强脂肪来源的干细胞的干性。 构成：用于增强脂肪来源的干细胞的干性的组合物含有0.001-3重量％的甘氨酸 - 脯氨酸 - 羟脯氨酸（Gly-Pro-Hyp）的三肽，0.01-50重量％的低分子透明质酸，0.001-3重量％ ％的矿物质和0.001-3重量％的维生素作为活性成分。 该组合物由ECM（细胞外基质）设计。 干细胞是人类脂肪干细胞（hADSCs）。

公开(公告)号：KR1020110018067A

公开(公告)日：2011-02-23

申请号：KR1020090075678

申请日：2009-08-17

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  박준성 ,  김동현 ,  노민수 ,  김덕희

IPC: A61K8/49 ,  A61K31/37 ,  A61Q19/08 ,  A61P17/18

CPC classification number: A61K31/37 ,  A61K8/498 ,  A61Q19/08 ,  A61K8/49

Abstract: PURPOSE: A composition containing ortho-dihydroxyisoflavone derivative for improving skin regeneration or skin elasticity is provided to induce proliferation of epidermal keratinocyte stem cells. CONSTITUTION: A composition for improving skin regeneration or skin elasticity contains 0.001-30 weight% of ortho-dihydroxyisoflavoen derivative of 4',7,8-trihydroxyisoflavone, 4',6,7-trihydroxyisoflavone, or 3',4',7-trihydroxyisoflavone as an active ingredient. An external use skin composition, pharmaceutical composition, or cosmetic composition contains the composition.

Abstract translation: 目的：提供含有用于改善皮肤再生或皮肤弹性的邻位二羟基异黄酮衍生物的组合物，以诱导表皮角化细胞干细胞的增殖。 构成：用于改善皮肤再生或皮肤弹性的组合物含有0.001-30重量％的4'，7,8-三羟基异黄酮，4'，6,7-三羟基异黄酮或3'，4'，7'-三羟基异黄酮的邻二羟基异佛尔酮衍生物， 三羟基异黄酮作为活性成分。 外用皮肤组合物，药物组合物或化妆品组合物含有该组合物。

公开(公告)号：KR1020110000716A

公开(公告)日：2011-01-05

申请号：KR1020100117492

申请日：2010-11-24

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K36/54 ,  A61Q19/00

Abstract: PURPOSE: A composition containing herb extract for skin care or plasty is provided to promoter differentiation of mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting differentiation to adipocytes contains Cinnamomum cassia extract as an active ingredient. The composition increases fat tissue. The mesenchymal stem cells are human bone marrow stem cells.

Abstract translation: 目的：提供含有皮肤护理或整形草药提取物的组合物，以促进间充质干细胞向脂肪细胞的分化。 构成：促进脂肪细胞分化的组合物含有肉桂提取物作为活性成分。 组合物增加脂肪组织。 间充质干细胞是人类骨髓干细胞。

公开(公告)号：KR1020100051286A

公开(公告)日：2010-05-17

申请号：KR1020080110377

申请日：2008-11-07

Applicant: (주)아모레퍼시픽

Inventor： 노민수 ,  여현주 ,  박선미 ,  신동욱 ,  이형호 ,  김한곤

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  G01N33/15 ,  G01N33/5008

Abstract: PURPOSE: A screening method of a skin improvement material is provided to effectively screen the skin improvement material capable of preventing skin ageing, maintaining skin moisture, and improving skin barrier function. CONSTITUTION: A screening method of a skin improvement material comprises the following steps: processing a candidate material to a skin cell; detecting an expression amount change of MAP17(membrane-associated protein 17kd); and selecting the candidate material which induces the change of the expression amount as the skin improvement material. The skin cell is a skin keratinocyte.

Abstract translation: 目的：提供皮肤改善材料的筛选方法，以有效地筛选能够防止皮肤老化，保持皮肤水分和改善皮肤屏障功能的皮肤改善材料。 构成：皮肤改善材料的筛选方法包括以下步骤：将候选材料加工到皮肤细胞; 检测MAP17（膜相关蛋白17kd）的表达量变化; 并选择引起表达量变化的候选材料作为皮肤改善材料。 皮肤细胞是皮肤角质形成细胞。

公开(公告)号：KR1020100005480A

公开(公告)日：2010-01-15

申请号：KR1020080065529

申请日：2008-07-07

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  이상민 ,  송민정 ,  박선미 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K36/736 ,  A61P3/04

CPC classification number: A61K36/39 ,  A61K36/23 ,  Y10S514/909

Abstract: PURPOSE: A composition containing pharbitidis seed, Anthriscs aemula Schisch and their mixture for body sliming is provided to suppress adipocyte differentiation and reduce lipid level. CONSTITUTION: A composition for body sliming contains pharbitidis seed extract, Anthriscs aemula Schisch extract or their mixture as an active ingredient. A composition for suppressing adipocyte differentiation contains the pharbitidis seed extract, Anthriscs aemula Schisch extract or their mixture as an active ingredient. Mesenchymal stem cells from human bone marrow are differentiated to adipocytes. The composition for sliming is used in the form of cosmetic composition, health food or pharmaceutical composition.

Abstract translation: 目的：提供含有pharbitidis种子，Anthriscs aemula Schisch及其混合物用于身体瘦身的组合物，以抑制脂肪细胞分化和降低脂质水平。 构成：用于身体瘦身的组合物含有药草种子提取物，Anthriscs aemula Schisch提取物或其混合物作为活性成分。 用于抑制脂肪细胞分化的组合物含有苦楝子种子提取物，Anthriscs aemula Schisch提取物或其混合物作为活性成分。 来自人骨髓的间充质干细胞被分化成脂肪细胞。 用于苗条的组合物以化妆品组合物，保健食品或药物组合物的形式使用。

公开(公告)号：KR1020080087273A

公开(公告)日：2008-10-01

申请号：KR1020070029255

申请日：2007-03-26

Applicant: (주)아모레퍼시픽

Inventor： 노호식 ,  백흥수 ,  박우람 ,  신의석 ,  신동욱 ,  김덕희 ,  장이섭

IPC: C07C233/07 ,  C07C233/10

Abstract: A 3,5-dihydroxybenzoic acid derivative compound having anti-obesity activity is provided to obtain a pharmaceutical agent for preventing and treating diseases caused by abnormal fat metabolism, including obesity, hyperlipidemia, diabetes by inducing activation of IDH3-alpha and CPT1 promoters. A 3,5-dihydroxybenzoic acid derivative compound having anti-obesity activity is represented by the following formula 1, wherein R is adamantyl, cyclohexyl or hexyl. The 3,5-dihydroxybenzoic acid derivative compound includes N-adamantyl-3,5-dihydroxybenzamide, N-cyclohexyl-3,5-dihydroxybenzamide or N-hexyl-3,5-dihydroxybenzamide.

Abstract translation: 提供具有抗肥胖活性的3,5-二羟基苯甲酸衍生物化合物，以获得通过诱导IDH3-α和CPT1启动子的激活来预防和治疗由异常脂肪代谢引起的疾病，包括肥胖症，高脂血症，糖尿病的药剂。 具有抗肥胖活性的3,5-二羟基苯甲酸衍生化合物由下式1表示，其中R是金刚烷基，环己基或己基。 3,5-二羟基苯甲酸衍生物包括N-金刚烷基-3,5-二羟基苯甲酰胺，N-环己基-3,5-二羟基苯甲酰胺或N-己基-3,5-二羟基苯甲酰胺。

公开(公告)号：KR100829691B1

公开(公告)日：2008-05-16

申请号：KR1020060119575

申请日：2006-11-30

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  신의석 ,  이형호 ,  이태룡 ,  조시영 ,  장이섭

IPC: A61K36/904 ,  A61K36/70 ,  A61P3/04

Abstract: 본 발명에 의한 지질 분해 촉진용 조성물은 사간 추출물, 갈퀴덩굴 추출물, 여뀌 추출물, 울릉국화 추출물 및 파드득나물 추출물로 구성된 군으로부터 선택된 하나 이상의 추출물을 유효성분으로 함유함으로써, IDH3α 유전자 프로모터의 활성을 유도하여 TCA 회로를 활성화시키고 이를 통해 지질의 산화 분해를 촉진시키는 기능을 하며, 더 나아가 비만의 치료 또는 예방, 고지혈증의 치료 또는 예방에 이용될 수 있다.
비만, IDH3α, TCA 회로, 갈퀴덩굴, 여뀌, 울릉국화, 파드득나물, 생약, 사간, 지질 분해