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    인간 중간엽줄기세포의 분화 촉진용 조성물
    2.
    发明公开
    인간 중간엽줄기세포의 분화 촉진용 조성물 有权
    促进人类间质干细胞分化的组合物

    公开(公告)号：KR1020120140450A

    公开(公告)日：2012-12-31

    申请号：KR1020110060194

    申请日：2011-06-21

    Applicant: (주)아모레퍼시픽

    Inventor： 신동욱 ,  노민수 ,  박수남

    IPC: A61K36/62 ,  C12N5/0775 ,  A61P17/00

    CPC classification number: A61K36/62 ,  A61Q90/00 ,  C12N5/0662 ,  C12N5/0669

    Abstract: PURPOSE: A composition with Nelumbinis Semen extracts as an active ingredient for promoting the differentiation of adipocyte in human mesenchymal stem cell is provided to promote differentiating the adipocyte from a human mesenchymal stem cell to produce lipid droplet, enhance the electricity and the volume of skin and reduce wrinkles. CONSTITUTION: A composition for skin external application for promoting the differentiation of adipocyte contains Nelumbinis Semen extracts as an active ingredient. The composition promotes differentiating adipocyte from a mesenchymal stem cell. The mesenchymal stem cell is a human mesenchymal cell. The composition increases adipocyte tissue. For the total weight of the composition, a Nelumbinis Semen extract weighs ranging from 0.001 to 30%. The composition enhances the volume of skin and the elasticity of skin, and reduces skin wrinkles. A pharmaceutical composition for promoting the differentiation of a adipocyte cell contains Nelumbinis Semen as an active ingredient. A Nelumbinis Semen extract is administered from 0.001mg /kg /day-2000mg /kg /day. [Reference numerals] (AA) Relative revelation amount; (BB) Negative control group; (CC) Ligustri Fructus; (DD) Veratri Rhizoma Et Radix; (EE) Forsythiae Fructus; (FF) Nelumbo semen

    Abstract translation: 目的：提供具有Nelumbinis Semen提取物作为促进人间充质干细胞中脂肪细胞分化的活性成分的组合物，以促进脂肪细胞与人间充质干细胞的分化，产生脂滴，增强皮肤的电力和体积， 减少皱纹。 构成：用于促进脂肪细胞分化的皮肤外用应用组合物含有Nelumbinis Semen提取物作为活性成分。 该组合物促进脂肪细胞与间充质干细胞分化。 间充质干细胞是人类间充质细胞。 组合物增加脂肪细胞组织。 对于组合物的总重量，Nelumbinis Semen提取物的重量范围为0.001至30％。 该组合物增强皮肤的体积和皮肤的弹性，并减少皮肤皱纹。 用于促进脂肪细胞分化的药物组合物含有Nelumbinis Semen作为活性成分。 Nelumbinis精液提取物以0.001mg / kg /天-2000mg / kg /天施用。 （附图标记）（AA）相对启示量; （BB）阴性对照组; （CC）Ligustri Fructus; （DD）Veratri Rhizoma Et Radix; （EE）连翘; （FF）Nelumbo精液

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