公开(公告)号：KR1020080099741A

公开(公告)日：2008-11-13

申请号：KR1020070045693

申请日：2007-05-10

Applicant: (주)아모레퍼시픽

Inventor： 이창근 ,  강병영 ,  김은주 ,  김한곤 ,  박신영 ,  안성연 ,  김지은

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K2800/87 ,  A61Q19/00

Abstract: A cosmetic composition for reducing an edema is provided to reduce an edema using gourd extracts, gingko leaf extract, question plant extracts, extract of chlorella, citrus extracts and caffeine. A cosmetic composition for reducing an edema comprises one or more ingredients selected from a group consisting of a Lagenaria siceraria var. gourda extract and a Helichrysum Italicum extract as an active ingredient. The cosmetic composition additionally contains one or more ingredients selected from a group consisting of gingko leaf extract, extract of chlorella, a citrus extract and caffeine. The coating method of the cosmetic composition for reducing the edema includes a step of compressuring skin using one of a roller, an acupressurer and a massage unit before coating the cosmetic composition. A skin-applicating apparatus contains the cosmetic composition and is one of the roller, the acupressurer and the massage unit.

Abstract translation: 提供了用于减少水肿的化妆品组合物，以减少使用葫芦提取物，银杏叶提取物，问题植物提取物，小球藻提取物，柑橘提取物和咖啡因的水肿。 用于减少水肿的化妆品组合物包含一种或多种选自以下的成分：Lagenaria siceraria var。 古德提取物和斜叶提取物作为活性成分。 化妆品组合物还含有一种或多种选自由银杏叶提取物，小球藻提取物，柑橘提取物和咖啡因组成的组分。 用于减轻水肿的化妆品组合物的涂布方法包括在涂敷化妆品组合物之前使用辊，指压按摩器和按摩单元之一来压缩皮肤的步骤。 皮肤施用装置包含化妆品组合物，并且是辊，指压和按摩单元之一。

公开(公告)号：KR100867596B1

公开(公告)日：2008-11-10

申请号：KR1020070034924

申请日：2007-04-10

Applicant: (주)아모레퍼시픽

Inventor： 김은주 ,  남개원 ,  이해광 ,  김승훈 ,  안성연 ,  문성준

IPC: G01N33/48 ,  G01N33/533

Abstract: 본 발명은 피부 각질 박리량을 정량할 수 있는 평가법으로서, 기존의 형광염색을 통해 육안적으로 각질 박리량을 평가하는 부분을 개선하여 이미지 분석 프로그램을 이용함으로써 각질박리량을 수치화하고, 객관적으로 각질 박리량을 검증할 수 있는 방법에 관한 것이다. 보다 상세하게는 피부 표면의 각질층을 형광염색시약으로 염색한 다음, 형광염색된 피부 표면에 각질 박리용 시료를 도포한 후 사진을 촬영하여 형광이미지를 얻음으로써 추적 관찰을 실시하고, 촬영한 사진의 형광이미지는 이미지 분석 프로그램을 이용함으로써 형광강도를 수치화하고, 형광이미지를 이용하여 3차원 이미지화 할 수 있다. 이를 통해 기존의 육안 판정에 의존하던 각질 박리 평가를 수치적으로 객관화 할 수 있으며, 3차원 이미지 변환을 통해 각질 박리 효과를 가시화 할 수 있다.
각질 박리, 형광염색, 댄실 클로라이드(Dansyl chloride), 디히드록시아세톤(Dihydroxyacetone), 이미지 분석, 형광강도, 흑백 전환

公开(公告)号：KR1020080091901A

公开(公告)日：2008-10-15

申请号：KR1020070034924

申请日：2007-04-10

Applicant: (주)아모레퍼시픽

Inventor： 김은주 ,  남개원 ,  이해광 ,  김승훈 ,  안성연 ,  문성준

IPC: G01N33/48 ,  G01N33/533

Abstract: A method for measuring the amount of human stratum corneum exfoliation is provided to digitize the stratum corneum exfoliation amount using an image analysis program by improving a conventional technique of evaluating the stratum corneum exfoliation amount visually through fluorescence staining, thereby verifying the stratum corneum amount objectively. A method for measuring the amount of human stratum corneum exfoliation comprises the steps of: (a) coating a fluorescent staining sample such as Dansyl chloride and dihydroxyacetone on a stratum corneum of skin surface for fluorescence-staining; (b) coating a sample for exfoliation such as glycolic acid, lactic acid, malic acid, citric acid, tartaric acid, salicylic acid and papain enzyme on the fluorescent-stained stratum corneum for 4-14 days to perform exfoliation; (c) fluorescence-photographing the exfoliated stratum corneum to obtain a fluorescent image; and (d) setting up an analysis area of the fluorescent image and digitizing fluorescence strength of the analysis by using an image analysis program. Further, the step (a) of coating a fluorescent staining sample is performed for 6 hrs.

Abstract translation: 提供了用于测量人角质层脱落量的方法，通过改进通过荧光染色目视评估角质层剥离量的常规技术，通过图像分析程序对角质层去角质量进行数字化，从而客观地验证角质层数量。 用于测量人角质层剥离量的方法包括以下步骤：（a）将荧光染色样品如丹酰氯和二羟基丙酮涂覆在皮肤表面的角质层上用于荧光染色; （b）在荧光染色的角质层上涂覆乙醇酸，乳酸，苹果酸，柠檬酸，酒石酸，水杨酸和木瓜蛋白酶等剥离性样品4-14天，进行剥离; （c）荧光拍摄剥离的角质层以获得荧光图像; 和（d）通过使用图像分析程序设置荧光图像的分析区域和数字化分析的荧光强度。 此外，涂布荧光染色样品的步骤（a）进行6小时。

公开(公告)号：KR100786300B1

公开(公告)日：2007-12-18

申请号：KR1020060090560

申请日：2006-09-19

Applicant: (주)아모레퍼시픽

Inventor： 유재원 ,  노호식 ,  김수정 ,  윤준원 ,  안성연 ,  김덕희

IPC: A61K8/49 ,  A61Q19/08

CPC classification number: A61Q19/08 ,  A61K8/498

Abstract: A 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety is provided to promote the biosynthesis of main constituents of skin dermis such as collagen, elastin, fibrillin, glycosaminoglycan(GAG) closely related to skin wrinkles, thereby being usefully used as medicines and skin external applying agents for preventing aging and improving the wrinkles. An anti-aging cosmetic composition comprises 0.01-20.0 wt.% of a 4-substituted benzoic acid derivative compound having 3,4-methylenedioxybenzene or 3,4-ethylenedioxybenzene moiety and represented by the formula(I), wherein R1 is -CH2- or -CH2=CH2-, R2 is the structural formula(Ia), and R3 is H, methyl or ethyl. A method for preparing the 4-substituted benzoic acid derivative compound comprises the steps of: (a) preparing a compound(1) represented by the formula(1) from 3,4-methylenedioxybenzoic acid or 3,4-ethylenedioxybenzoic acid; and (b) hydrolyzing the compound of the formula(1) with a base to prepare a compound(2) represented by the formula(2).

Abstract translation: 提供具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分的4-取代苯甲酸衍生物化合物，以促进皮肤真皮主要成分的生物合成，如与皮肤皱纹密切相关的胶原蛋白，弹性蛋白，纤维蛋白，糖胺聚糖（GAG） 从而有效地用作用于防止老化和改善皱纹的药物和皮肤外用施用剂。 抗衰老化妆品组合物包含0.01-20.0重量％的具有3,4-亚甲二氧基苯或3,4-亚乙二氧基苯部分并由式（I）表示的4-取代苯甲酸衍生物化合物，其中R 1是-CH 2 - 或-CH 2 = CH 2 - ，R 2是结构式（Ia），R 3是H，甲基或乙基。 制备4-取代苯甲酸衍生物化合物的方法包括以下步骤：（a）由3,4-亚甲二氧基苯甲酸或3,4-亚乙二氧基苯甲酸制备由式（1）表示的化合物（1） 和（b）用碱水解式（1）的化合物以制备由式（2）表示的化合物（2）。

公开(公告)号：KR1020070106080A

公开(公告)日：2007-11-01

申请号：KR1020060038518

申请日：2006-04-28

Applicant: (주)아모레퍼시픽

Inventor： 안성연 ,  양혜진 ,  박재희 ,  이해광 ,  문성준

IPC: G01M99/00

Abstract: A system for measuring the in-vitro water resistance SPF of a sunscreen agent and a method for measuring the SPF by using the same are provided to predict the water resistance degree of a product without performing an actual clinic test. A system for measuring the in-vitro water resistance SPF of a sunscreen agent includes a drive section(10), and a rotary blade(20). The drive section includes a rotational shaft(11). The rotational shaft is submerged in the water in a washing tub. The rotary blade is installed at one end of the rotational shaft. An ultraviolet sunscreen agent is coated on a surface of the rotary blade. The ultraviolet sunscreen agent is washed out in the water by rotating the rotary blade driven by the drive section. The rotary blade has a plurality of blade ribs(22) extended vertically at one end of the rotational shaft, and substrates(24) coated with the ultraviolet sunscreen agent.

Abstract translation: 提供了一种用于测量防晒剂的体外抗水性SPF的系统和使用该防晒剂的SPF测量方法，以预测产品的耐水性，而不进行实际临床试验。 用于测量防晒剂的体外防水性SPF的系统包括驱动部分（10）和旋转叶片（20）。 驱动部分包括旋转轴（11）。 旋转轴浸入洗涤桶中的水中。 旋转叶片安装在旋转轴的一端。 紫外线防晒剂涂覆在旋转刀片的表面上。 通过旋转由驱动部驱动的旋转刀片，紫外线防晒剂在水中洗出。 旋转刀片具有在旋转轴的一端处垂直延伸的多个叶片肋（22）和涂覆有紫外线防晒剂的基底（24）。