公开(公告)号：KR1020090022815A

公开(公告)日：2009-03-04

申请号：KR1020070088452

申请日：2007-08-31

Applicant: (주)아모레퍼시픽

Inventor： 이소미 ,  이재경 ,  정혜진

IPC: G01N30/02 ,  G01N30/00

Abstract: A simultaneous analysis method of sunscreen agents is provided to ensure reproducibility, accuracy, reduction of screening time and convenience, to detect sunscreen agents present in cosmetic materials and to analyze compounds having lipophilic property and hydrophile property at the same time. A simultaneous analysis method of sunscreen agents comprises the steps of (i) extracting lipophilic and hydrophilic sunscreen components by adding the solution mixed with dimethylformamide and methanol in a volume ratio of 1 : 0.9-1.2 to cosmetic materials having lipophilic and hydrophilic sunscreen components; (ii) injecting lipophilic and hydrophilic sunscreen components in a reverse-phase non-polar column filled with octadecylsilane(C18), dodecylsilane(C12) or octasilane(C8) having non-polar as a fixed bed; and (iii) performing quantitative analysis and qualitative analysis of lipophilic and hydrophilic sunscreen components with liquid chromatography by using the mixed solution of water and ethanol, or ethanol as a mobile phase.

Abstract translation: 提供防晒剂的同时分析方法，以确保化妆品中存在的防晒剂的重现性，准确性，降低筛选时间和便利性，同时分析具有亲油性和亲水性的化合物。 防晒剂的同时分析方法包括以下步骤：（i）通过将与二甲基甲酰胺和甲醇混合的体积比为1:0.9-1.2的溶液与具有亲脂性和亲水性防晒组分的化妆品相加，提取亲油性和亲水性防晒组分; （ii）在装有非极性的十八烷基硅烷（C18），十二烷基硅烷（C12）或辛硅烷（C8）的反相非极性柱中注入亲脂性和亲水性的防晒组分作为固定床; 和（iii）通过使用水和乙醇或乙醇作为流动相的混合溶液，用液相色谱法进行亲油和亲水防晒组分的定量分析和定性分析。

公开(公告)号：KR1020090021501A

公开(公告)日：2009-03-04

申请号：KR1020070086062

申请日：2007-08-27

Applicant: (주)아모레퍼시픽

Inventor： 이소미 ,  김용진 ,  주경미 ,  정혜진

IPC: A61K8/42 ,  A61K31/425 ,  A61K31/535 ,  A61Q19/08

CPC classification number: A61K8/42 ,  A61K8/04 ,  A61K9/0014 ,  A61K31/167 ,  A61K2121/00 ,  A61Q19/08

Abstract: Provided is a method for stabilizing benzamide compounds to manufacture skin medicines for external use, including the benzamide compounds as an active ingredient without any structure changes. A composition of skin medicines for external use has pH of 5 or less. Benzamide compounds of which a substituted group is not decomposed exists within the composition. The benzamide compounds are selected from the group consisting of 3,5-dihydroxy-N-(4-hydroxyphenyl)benzamide, N-Phenylbenzamide, t-butylbenzamido hydroxybenzamide, 2-hydroxy-N-phenylbenzamide, and t-butylbenzamido methylhydroxybenzamide.

Abstract translation: 提供了一种稳定苯甲酰胺化合物以制造外用皮肤药物的方法，包括苯甲酰胺化合物作为活性成分而没有任何结构变化。 外用皮肤药物的组合物的pH为5以下。 在组合物内存在取代基未分解的苯甲酰胺化合物。 苯甲酰胺化合物选自3,5-二羟基-N-（4-羟基苯基）苯甲酰胺，N-苯基苯甲酰胺，叔丁基苯甲酰氨基羟基苯甲酰胺，2-羟基-N-苯基苯甲酰胺和叔丁基苯甲酰氨基甲基羟基苯甲酰胺。

公开(公告)号：KR1020040084364A

公开(公告)日：2004-10-06

申请号：KR1020030019384

申请日：2003-03-28

Applicant: (주)아모레퍼시픽

Inventor： 주희경 ,  김진웅 ,  이소미 ,  한상훈 ,  장이섭

IPC: A61K9/50

CPC classification number: A61K8/11 ,  A61K8/345 ,  A61K8/84 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q19/00

Abstract: PURPOSE: Provided are a stabilization method of active ingredients inside hydrophobic polymer by increasing solubility of the active ingredients and using polyol/polymer microcapsules and a cosmetic composition containing the microcapsules to maximize its efficacy. CONSTITUTION: The method for manufacturing polyol/polymer microcapsules comprises the steps of: dissolving at least one kind of active ingredient selected from the group consisting of water soluble or insoluble active ingredients in polyol/solvent; dispersing the solution and emulsifying it to give emulsion; and removing the polyol/solvent from the emulsion and recovering hard polymer microcapsules.

Abstract translation: 目的：通过提高活性成分的溶解度和使用多元醇/聚合物微胶囊和含有微胶囊的化妆品组合物来提供其功效最大化的疏水性聚合物内的活性成分的稳定化方法。 构成：制造多元醇/聚合物微胶囊的方法包括以下步骤：将选自水溶性或不溶性活性成分的至少一种活性成分溶解在多元醇/溶剂中; 分散溶液并乳化，得到乳液; 并从乳液中除去多元醇/溶剂并回收硬聚合物微胶囊。