公开(公告)号：KR1020140021153A

公开(公告)日：2014-02-20

申请号：KR1020120086956

申请日：2012-08-08

Applicant: 서울대학교산학협력단

Inventor： 박영배 ,  김효수 ,  허진 ,  최재일 ,  김준오

IPC: A61K35/14 ,  A61K35/15

CPC classification number: A61K35/14 ,  A61K35/15

Abstract: The present invention relates to a technology in which only trace amounts of adult stem cells and progenitor cells present in the blood are effectively cultured and proliferated by using blood mononuclear cells, thereby differentiating inflammatory mononuclear cells into anti-inflammatory mononuclear cells and efficiently securing masses of anti-inflammatory Type 2 helper lymphocytes and regulatory lymphocytes, and a method for treating immune-related diseases using the technology. The anti-inflammatory mononuclear cells, Type 2 helper lymphocytes, and regulatory lymphocytes according to the present invention are immune cells derived from patients, and thus can greatly contribute to the development of cell therapeutic agents for autoimmune diseases.

Abstract translation: 本发明涉及通过使用血液单核细胞有效地培养和增殖存在于血液中的微量成体干细胞和祖细胞的技术，从而将炎症性单核细胞分化成抗炎单核细胞，有效地确保 抗炎2型辅助淋巴细胞和调节性淋巴细胞，以及使用该技术治疗免疫相关疾病的方法。 根据本发明的抗炎单核细胞，2型辅助淋巴细胞和调节性淋巴细胞是来自患者的免疫细胞，因此可大大有助于自身免疫性疾病的细胞治疗剂的发展。

公开(公告)号：KR1020130085383A

公开(公告)日：2013-07-29

申请号：KR1020130005902

申请日：2013-01-18

Applicant: 서울대학교산학협력단

Inventor： 박영배 ,  김효수 ,  허진 ,  최재일 ,  양지민

IPC: A61K35/14 ,  A61K35/12 ,  A61P3/10

Abstract: PURPOSE: A pharmaceutical composition for treatment of metabolic diseases including a blood-born hemosphere (BBHS) is provided to be able to be used as medicine for metabolic diseases by inducing differentiation of BBHS to an insulin-secreting cell. CONSTITUTION: A pharmaceutical composition for treatment of metabolic diseases includes BBHS. The BBHS is formed by isolating monocytic cells from human blood and performing the three dimensional aggregation cultivation. The BBHS is induced to an insulin-secreting cell. The metabolic diseases are selected from a group consisting of diabetes, hyperlipidemia, and obesity. A method of curing metabolic diseases administers the pharmaceutically effective dose of the pharmaceutical composition to an individual.

Abstract translation: 目的：提供一种用于治疗包括血液生成气体（BBHS）在内的代谢疾病的药物组合物，通过诱导BBHS分泌到胰岛素分泌细胞，能够用作代谢疾病的药物。 构成：用于治疗代谢疾病的药物组合物包括BBHS。 BBHS通过从人血液中分离单核细胞并进行三维聚集培养而形成。 BBHS被诱导到胰岛素分泌细胞。 代谢疾病选自糖尿病，高脂血症和肥胖症。 治疗代谢疾病的方法将药物组合物的药学有效剂量给予个体。

公开(公告)号：KR1020100116812A

公开(公告)日：2010-11-02

申请号：KR1020090035421

申请日：2009-04-23

Applicant: 서울대학교산학협력단

Inventor： 박영배 ,  김효수 ,  조현재 ,  이호재

IPC: C12N5/07 ,  C12N5/02

Abstract: PURPOSE: A method for inducing and culturing cardiac stem cells using cell aggregation is provided to extract obtain a large amount of stem cells. CONSTITUTION: A method for inducing and culturing cardiac stem cells using cell aggregation comprises: a step of isolating differentiation cells from heart; a step of culturing cells in a three-dimensional structure; a step of proliferating cells and culturing organ; and a step of culturing and storing for a long time and thawing again to obtain secondary cardiac sphere.

Abstract translation: 目的：提供使用细胞聚集诱导和培养心脏干细胞的方法，以提取获得大量的干细胞。 构成：使用细胞聚集诱导和培养心脏干细胞的方法包括：从心脏分离分化细胞的步骤; 以三维结构培养细胞的步骤; 增殖细胞和培养器官的一个步骤; 以及长时间培养和储存并再次解冻以获得二次心脏球的步骤。